Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MMSNLMMDSPKSSPHGGGRSPVVARQDSSGTLKTTISLGKTPTIIHTGPFYSMKEPPAKAELTGDKDLMTEYGLHHTLSKFKEKKFKESLASFLQNIPGINDLITHPVENSTLRSVIEKPPIGGKELLPLTPVQLAGFRLHPGPLPEQYRTTYVTPARKHKNKHKKHKHKDGVTTGQESTLLDSAGLETYEKKHKKQKRHEDDKERKKRKKEKKRKKKNQSPEPGVGLLPGGGTGLGGGPGVMGATSLGSLGGGPGPGLSSLSASMGPGVVGGMNSFSSSMQMQQQQQQIPMQQQQMSSGGLLGSVLGTSGGPGGTGGGGGGVGGGGGVGSGSGGGSLLMSQF |
Length | 343 |
Position | Head |
Organism | Drosophila ananassae (Fruit fly) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.676 |
Instability index | 57.59 |
Isoelectric point | 9.95 |
Molecular weight | 35774.40 |
Publications | PubMed=17994087 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro transcription factor binding GO:0008134 IEA:EnsemblMetazoa |
GO - Biological Process | positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblMetazoa |
Binary Interactions |
Repeats | >MDP24963 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 60.96| 12| 32| 160| 171| 3 --------------------------------------------------------------------------- 160- 171 (23.67/12.88) HKNKHKKHK.HKD 190- 202 (18.23/ 8.63) YEKKHKKQKrHED 208- 219 (19.06/ 9.28) KRKKEKKRK.KKN --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 97.05| 30| 32| 54| 84| 4 --------------------------------------------------------------------------- 54- 83 (53.11/27.76) KEPPAK..AELTGDKDLMTEYGLHHTLSKFKE 87- 118 (43.94/22.16) KESLASflQNIPGINDLITHPVENSTLRSVIE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 68.70| 19| 54| 267| 285| 7 --------------------------------------------------------------------------- 267- 285 (37.73/17.45) GPGVVGGMNSFS..SSMQMQQ 322- 342 (30.96/12.90) GVGGGGGVGSGSggGSLLMSQ --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) GGSLLMSQF 2) LLGSVL | 335 302 | 343 307 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab