Description | Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MAAVDIRDNLLGISWVDSSWIPILNNGTVLDYFSERSNPFYDRTCNNEVVKMQRLTLDHLNQMVGIEYILLHAQEPILFIIRKQQRQSPTQVIPLADYYIIAGVIYQAPDLGSVINSRVLTAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDQEERDKTKPKAKKKEEASSHFQRQRVDALLMELRQKFPPKFIQQKTGEKPVPVEQIKKEAEPPAETIKQEEKEPVKVAQQGATPKGPPEKRMRLQ |
Length | 246 |
Position | Head |
Organism | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Silurana. |
Aromaticity | 0.09 |
Grand average of hydropathy | -0.630 |
Instability index | 48.80 |
Isoelectric point | 8.89 |
Molecular weight | 28457.32 |
Publications | PubMed=20431018 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 PIRNR:PIRNR023869 |
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central mediator complex GO:0016592 IBA:GO_Central |
GO - Biological Function | transcription coactivator activity GO:0003713 IBA:GO_Central |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central |
Binary Interactions |
Repeats | >MDP24953 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 61.98| 21| 22| 193| 214| 1 --------------------------------------------------------------------------- 189- 212 (29.05/21.67) PP.kfIQQKTGEkPVPVEQIKKEAE 213- 236 (32.93/19.96) PPaetIKQEEKE.PVKVAQQGATPK --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) IKQEEKEPVKVAQQGA 2) PKGPPEKRMRLQ | 218 235 | 233 246 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab