<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24948

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMDSLNNVALRPWPAPKKEELTQEDLLFKIEQLASERGHLRNITEQSLQEDIDAGKNAPGHGSDAGAVKEEEKKEKEAPSLQEQREKVLKVGMEMYSHLEWAKFAANNALDLVSLILSQDPNKRSLNFFSPTFQEQGLKQGIPLGSFGVSKENHEHRVRKPEEQHRLQDLEARQEAVAQGARMGALDSSVDEILKAAKNLEKQIRRETKYWHEIVTVSDKGWPIQRLRQNVRHAPFGVRYGLPEASDHFKARGFAPLQMDKDGSIILDPALALKPKILRVRVSIDGNITGTTQLSAADDLANQSLEKSIQLARDSLLEEELYYEMSLETRQLLAYGVEFRDSVIYVDAPQMGGVSHERKLLIDCIPRDDPVPSSRSHEHDWMARNIAEGLRLLLAHEHSMRLYRRSQLPPPLTTRKREKPSPSLLRTLLAVIHHIEAVDSLYVYLESLARTLNSVGLDVTLDTTRETSWATLVESLGTPSMKGQSATDQLFEVFMKPFDGKATMSLPVSTGAQHESLSITTRTIIGQPTFGTEHKLILPPTLGIDLGLSQQQKFAAVEEITSLLQNEYSSRAQALSQDARLSIKGKDRKKGVKSSKDIEIELNNGELKASVLIVDTVQDIEEVEQSRTWSGKDGNNSSLREVIKSWVD
Length647
PositionHead
OrganismPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Pyrenophora.
Aromaticity0.05
Grand average of hydropathy-0.528
Instability index51.72
Isoelectric point5.92
Molecular weight72549.28
Publications
PubMed=23316438

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24948
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     214.12|      62|     220|     315|     377|       1
---------------------------------------------------------------------------
  315-  377 (100.92/74.13)	LLEEELYYEMSLETRQLLAyGVEFRDSVIYVD.APQMGGVSHERKLL.IDCIPRDD......PVPSSRSHE
  478-  514 (23.89/10.25)	..................................PSMKGQSATDQLFeVFMKPFDGkatmslPVSTGAQHE
  536-  598 (89.31/60.05)	ILPPTLGIDLGLSQQQKFA.AVEEITSLLQNEySSRAQALSQDARLS.IKGKDRKK......GVKSSKDIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.76|      70|     116|      13|      83|       2
---------------------------------------------------------------------------
   13-   83 (110.21/79.86)	PAPKKEELTQEDLL..FKIEQLASERgHLRNITEQSLQEDIDAGKNAPGHGSDAGAVKEE.EKKEKEAPSLQEQ
  130-  202 (107.56/72.89)	PTFQEQGLKQGIPLgsFGVSKENHEH.RVRKPEEQHRLQDLEARQEAVAQGARMGALDSSvDEILKAAKNLEKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.00|      22|      38|     389|     411|       4
---------------------------------------------------------------------------
  389-  411 (37.12/28.59)	LRLLLAHEH......SMRLYRRSqLPPPL
  424-  451 (30.88/18.40)	LRTLLAVIHhieavdSLYVYLES.LARTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24948 with Med17 domain of Kingdom Fungi
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