<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24946

Description Uncharacterized protein
SequenceMTSRPGPGIHESLQNRGSGVPPRTQAQRRASKPAHTLLHPDCIDPALDDERPAAHHAAHDAACPPPRGRPPLFYTTIAQYPLDFHPHGLPYQPSVNLPVPPRPGLVHLRDAAHQRRILPGGSGVKDAPKSGAPEVIVPPVYFPGGKPADLFPWTGNNAEDNLTETLVKAGVSNKPQIMNESNTARPSLINNLKNKSGLSTLSTLFVAVLEKRQQTGRLQTPNTFKPPPRLTLRDSTREQWLHDLANPNTGLRRLSRTIPHGLTGKVLLEQCLNKNIPLPRALWLAKCVGINELRAHKRKGQAGTVTWGRGWTSSVEQFIDGVIGTIGQGDWKPRITYALQLATHLYKEHLLDDDHFLDWIVDGLGSCPSERLFIWLLIVSVSHYWADVSCCRRRGRRLAESLLNQLDKIYRVEDVNPYLAVLHYLENTVIRLIATIPACLLLPTAWAKYSPLLVQLAERRNHPHVTQAVRRLEQRNSRLLQSSKNLPSASQTPAGRVYRILDSVDYNRPVRIEDLSLDCMEVVADAPRLIDILLRWACSCYREGSHRIYLATRLLRKWAHLGADVYDGILSHFHELTWVATGESSILFKIVAELVRSKTFATGRYLQWLIATGSIGHSTDLSSPTAWALRLITEIPLTGLPEQIRLLRSTLLRGTIHSAEQEQHALCYVEHMISQSLPALFGHCNAATRLNESELDKLSSTVKLELGIWLRQHVAQYAEVNQHVPTKDPSVEETAAVSLLTPLDFHVVRSYLERFGDLAILADIVGIAISSLDPGVLAAAADTLNYHSKSFRAIGAFDPLYTRIAARYLALRTVRYPDRELLLSLSNLTRPTQADSQLSQLLSYDLGQLTQRNSLAACSPASDNMGEVMQTGSSSDDEIERILSSGNSMDQQMMSRVLRKIVGNLEEHAAKGSVQLNNQHAWFHRLRCFDESTFDMVVNEWLILSLMAQRTETLRVALPTLVGSGCIALSSFLDAIRACVAKFKTNPSEGGFRSALKGMHIILPSETLVQCCSPQDAYRYRLEQRRLCMAAESRFTHCISEMIGLGSMLSSQKVHAQLSHLLCSKPVLFLLKHHIITDPGYLSKLNTDASSHYFKQSLDILLDPNSHLRLSEKDPENRIVSVFALASELSLPICQAALEQIFSSGVASPGSSHETLSATLLSAIRTAVEEDQPSGLELLASLDAALTEQIRQHAERELISASTFLTIPSNVKADEFELVSPTVIQKFLTVIDLTSSKRTDTTDQSALLQALIERFKGIAQALDNNRLSILDVYAWLSALLRLVVSHASAMLSNATHPHQTAMMSAMAALLTHQSLELYPTITEHIFDVTVYLSDYISDDVRFHVTRLEGMKLANDSRCVFILGVTAPVDGWLVLAKPVSTPMNQVTSQPPTPAPLQTQSTPYQSPQSSAAGSATPQQRYMNQQQQQQQRQQQLQAAQQVQHMRASQQYHQHPQNKMLPVQLQRTPSSQASPSPLSQMQQMQQMQQRAMQPSLAYSQRPTPAAGQVHMGSQGQMGGQAPGKPQMRQERDVRYYPFVQPRWEILAESSGNPTGNETAINLSLFGARKV
Length1566
PositionKinase
OrganismPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Pyrenophora.
Aromaticity0.06
Grand average of hydropathy-0.241
Instability index49.53
Isoelectric point8.60
Molecular weight173917.70
Publications
PubMed=23316438

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP24946
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     125.62|      25|      25|    1416|    1440|       1
---------------------------------------------------------------------------
 1382- 1398 (23.03/ 7.51)	.....MNQVTSQPPT.........PAPLQT....Q
 1416- 1440 (46.14/22.03)	QQ.RYMNQQQQQQQR.........QQQLQAAQQVQ
 1442- 1462 (29.65/11.67)	.....MRASQQYHQH.........PQNKMLPVQLQ
 1472- 1505 (26.81/ 9.88)	SPlSQMQQMQQMQQRamqpslaysQRPTPAAGQV.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.79|      24|      25|     146|     170|       3
---------------------------------------------------------------------------
  128-  144 (22.84/11.19)	......PKSG..APEVIVPPV.YFPG
  146-  170 (36.74/29.78)	KPADLfPWTGNNAEDNLTETL.VKAG
  174-  197 (33.22/20.71)	KPQIM..NESNTARPSLINNLkNKSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     656.27|     170|     175|     477|     651|       5
---------------------------------------------------------------------------
  278-  464 (214.18/135.51)	LPRALWLAKC........vginelrahkrkgqagtvtwgrgwtS....SVEQFIDGVIG...TIGQG......DW.KP.RITyALQLATHlykEHLLDDDHF.LDWIVDGLGSC...PSERLFIWL.LIVSVS......HYWADV.SCCRRRGRRLAESLLNQLDKIYRV..EDV..................NPYL.AVLHY..LENTVIRLIATIPACLLLPTAWAkyspllVQLAERRNHPH
  465-  639 (271.58/186.50)	VTQAVRRLEQRNSRllqS.........................SknLPSASQTPAGRVY...RILDSV.....DYNRPVRIE.DLSLDCM...EVVADAPRL.IDILLRWACSCYREGSHRIYLATRLLRKWA......HLGADVYDGILSHFHELTWVATGESSILFKIVAELV.................RSKTF.ATGRY..LQWLIATGSIGHSTDLSSPTAWA......LRLITEIPLTG
  640-  815 (170.51/106.12)	LPEQIRLLRSTLLR...G.........................T..IHSAEQEQHALCYvehMISQSLpalfgHCNAATRLN.ESELDKL......SSTVKLeLGIWLRQHVAQYAEVNQHVPTKDPSVEETAavslltPLDFHVVRSYLERF........GDLAILADIVGIAIssldpgvlaaaadtlnyHSKSFrAIGAFdpLYTRIAARYL............A......LRTVR......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.79|      16|      24|    1156|    1171|       6
---------------------------------------------------------------------------
 1156- 1171 (24.65/14.97)	LSATLLSAIRTAVEED
 1182- 1197 (26.14/16.34)	LDAALTEQIRQHAERE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     140.39|      54|     181|      59|     123|       7
---------------------------------------------------------------------------
   20-   98 (79.69/56.61)	VPPRTQ.AQRRASKpahtllHPDCIDPALDD.............................................................................................................erpaahhaaHDAACPPPRGRppLFYTTIaqypldfhPHGLP....YQPSVNLP
   99-  123 (24.48/ 7.60)	VPPRPGlVHLRDAA......HQRRILPGGSG..................................................................................................................................................................
  242-  275 (36.22/12.88)	...............................vkdapksgapevivppvyfpggkpadlfpwtgnnaednltetlvkagvsnkpqimnesntarpslinnlknksglstlstlfvavlekrqqtgrlqtpntfkppprltlrdstreqwlHDLANPNTGLR..RLSRTI........PHGLTgkvlLEQCLNKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.37|      24|      24|    1274|    1297|       8
---------------------------------------------------------------------------
 1246- 1269 (34.62/19.93)	ALLQALIERFKGIAQALDNNRLSI
 1274- 1297 (40.21/24.37)	AWLSALLRLVVSHASAMLSNATHP
 1301- 1317 (19.54/ 7.96)	AMMSAMAAL.LTHQSLEL......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.64|      22|      24|     992|    1013|       9
---------------------------------------------------------------------------
  992- 1007 (21.20/ 9.15)	..........FRSAL..KGMHIILPSET
 1008- 1033 (30.23/16.19)	LVQCCSpqdaYRYRL..EQRRLCMAAES
 1035- 1061 (23.20/10.71)	FTHCISemigLGSMLssQKVHAQL.SHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.77|      12|      18|     843|     854|      11
---------------------------------------------------------------------------
  843-  854 (21.03/12.40)	SYDLGQLTQRNS
  862-  873 (21.75/13.08)	SDNMGEVMQTGS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24946 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GLPYQPSVNLPVPPRPGLVHLRDAAHQRRILPGGSGVKDAPKS
2) LTETLVKAGVSNKPQIMNESNTARPSLINNL
3) MTSRPGPGIHESLQNRGSGVPPRTQAQRRASKPAHTLLHPDCIDPALDDERPAAHHAAHDAACPPPRGRP
4) STPMNQVTSQPPTPAPLQTQSTPYQSPQSSAAGSATPQQRYMNQQQQQQQRQQQLQAAQQVQHMRASQQYHQHPQNKMLPVQLQRTPSSQASPSPLSQMQQMQQMQQRAMQPSLAYSQRPTPAAGQVHMGSQGQMGGQAPGKPQMRQERDVR
88
162
1
1379
130
192
70
1530










Molecular Recognition Features






MoRF SequenceStartStop




1) RDVRYYPFVQPRWE
2) YTTIA
1527
74
1540
78