<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24945

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMQGRTALAHGVPSYICCPTESDVQGDFEAIAYQAFSIARTSTTPTLSRIRDWGSAEDIRAAEAELRKQLQLVAQDASRPWLWLFKPTTVDKAGQNNADLPDIDGYHLQREHAGCIKAIDLVRPPVRTGTPNTSTSSKPSSSSAAASHSGQGGSARPTQANSQPQTSADPPQSPDCFTIYELFTSSVIALISFHIVKDCNVVALNYRTFVSRASKRLENDQAEIKSPDVHRLTSITVHWTSSGTLLVSTFTDPKTVIRCLGHVSTPAEESQLAGRCIRVAPNGMLATISSFEDPIESVVDEIGVRHRKRTRLTSLEQNIEKWKSSVERWLGWKGYALPDLDKRTSWVRIRTAPSSLPASSPAAPSPDRDILWPRALCFFHVSQDHEITAAESSTSAGNHNMLRWFETPESAGFKDPLDAAQEWFLGKQDRDKLLEAQRKAKKAEEDAARRKEEQHNLYPSSPLNARAGAYGDLPAVSGVYPTPPDGVAPGAGISQSDTPSVSGTVSNVILAPGGSTPAINLSAPADTKMEDQQLPLTSPVILPAPDNHNTSSGNDDLFEDMDEDGFGGDRINDTDFDFFDGPDNHDVDMLDAPALPDHNTAHTDAPHEPHHVTEPQVQDDMSDPFAALENALATASEPVVSEETDVKGKEPATAQASSFDVPETSEKKAVMPSSLVKVTFSKEPTPPLSPSAVFKALQPSPPYKSGSRTQQKRPSTSQHNTQFDPVAFSRKMSMSDAKYQDGRFSAHGHTEPAIKKTTPSPGPGTAPVQAKSLRDFPLLTKLRLAVGMASANKIPEIACLARAASEDLESSSDTSDASGEDSEEEEEIERTPVAILNSLVMPAKRKLQSEGNATPLSVTSFAESMGGDWQDLYALQLDEANLSTFEPSLFDWSLVNFPSPAERVATGARYSFPALLPSPSQMPDTPTSQPDLNYEVPEEKPLNGKDIISITQIVTDQIVSATLDVLGEDPLTENISEDSAAIEMHWQTAIKDVFPTAEDCDLPKLVGIHEVFQDYAALAKAQQRPPARKTDGPAITSSHMYQINPPHLRVRRADTHWDLLPPAVAFWEPLGLSPISSPKNIVSFCVYPHSDALRPCLENFLLNLQLAYDSCKLGSHSRVETVMEFEGGLVPVRATTASSPRETFKLLKDACIQLGRLLALQYAKIREQQDSNIDAFVIYMIDPFGGPSALWELCSAFWSLFQAYGQGPPGRPEQPQKPDLVLQVIPIKYIASFDAPVILDPSTYFNLAREVYDRCPPSAPSGDKTSLSIYSAPAFHLEETLPRNIPFKLVAEPAQDLLRENTYMHLGYAISLDGTWVTAAWTDSCGKSQAVVSYHLGTRMFREIAKEIWQNTIEILQSRRVNWRVCIAKAGVLEREELESWVFLISCPTQINVFVTLLTAVDADPPYQFTPTMSSSNQSNTAATANTPVSTPQAGVSPSDPGPGLTPAATPSADPSATDPAADPEARLVDITDETWGIVLAHRLHNSYSTTQFSPALISGLLVKRGETLQTRNNILHPIPDPETGPIVVAVNFLWIGAVGSTRTTNSPFSATSSTGTNTSSSSSSSSSSTADIPSPNTTGLPNPYPSSTSTPQSPSPGPGQQEAGQRSTTSLMWTPTPQTRTTAEGLLKEVLGQFRALGLLAKLRGMRGTRGGTVPWHVVAAKRGVEGLGRVGGGF
Length1675
PositionKinase
OrganismPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Pyrenophora.
Aromaticity0.07
Grand average of hydropathy-0.385
Instability index57.60
Isoelectric point5.14
Molecular weight181390.72
Publications
PubMed=23316438

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24945
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     114.26|      19|      20|    1557|    1575|       1
---------------------------------------------------------------------------
  130-  148 (32.51/12.41)	PNTST..SSKPSSSSAAASHS
 1446- 1463 (24.83/ 7.40)	PAATP..SADPSATDPAADP.
 1557- 1574 (23.75/ 6.69)	.NTSS..SSSSSSSSTADIPS
 1575- 1595 (33.16/12.83)	PNTTGlpNPYPSSTSTPQSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.89|      18|      20|     545|     562|       3
---------------------------------------------------------------------------
  393-  412 (21.33/ 9.16)	TSAGNH...NMlrwFETPES............AGF.
  549-  566 (34.00/19.04)	TSSGND...DL...FEDMDE............DGFG
  567-  598 (18.56/ 7.00)	GDRINDtdfDF...FDGPDNhdvdmldapalpD.HN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.18|      19|      20|     628|     646|       4
---------------------------------------------------------------------------
  628-  646 (30.68/18.73)	ENALATASEPVVSEETDVK
  649-  667 (32.50/20.36)	EPATAQASSFDVPETSEKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.66|      27|      31|     483|     511|       5
---------------------------------------------------------------------------
  461-  481 (31.12/15.55)	PLNARAGA...YGDLPAVSGV.........YPT...
  483-  509 (48.94/28.57)	PDGVAPGAGISQSDTPSVSGT.........VSNVIL
  511-  541 (30.60/17.96)	PGGSTPAINLS...APA..DTkmedqqlplTSPVIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.11|      15|      30|     994|    1008|       6
---------------------------------------------------------------------------
  994- 1008 (28.45/16.15)	PTAEDCDLPKLVGIH
 1024- 1038 (27.66/15.47)	PPARKTDGPAITSSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.55|      30|      30|    1246|    1275|       8
---------------------------------------------------------------------------
 1223- 1243 (33.71/12.51)	VIPIKYIAS..FD.........APV..ILDPSTY
 1244- 1269 (41.20/17.03)	....FNLAREVYDRCPP....SAPSGDKTSLSIY
 1270- 1295 (24.63/ 7.03)	SAPAFHL.EETLPRNIPfklvAEPAQD.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.74|      34|     815|     222|     265|       9
---------------------------------------------------------------------------
  227-  260 (59.38/46.44)	DVHRLTSITVHWTSSGTL.LVSTFTDP.KTVIRCLG
  267-  302 (49.36/18.31)	EESQLAGRCIRVAPNGMLaTISSFEDPiESVVDEIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.65|      31|     816|     687|     725|      13
---------------------------------------------------------------------------
  700-  759 (34.75/27.61)	PPYksgsrtqQKRPSTSQHNTQFD......PVafsrkmsMSDAkyqdgrfsahghtepAI.KKTTPS
 1404- 1441 (47.90/27.29)	PPY.......QFTPTMSSSNQSNTaatantPV.......STPQ...............AGvSPSDPG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24945 with Med13 domain of Kingdom Fungi
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