<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24943

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNHSASNAAAASRDGDIKKRAHDGSLTNGASTAIATPKGPTPEHYEEPPEIEHVGDEQYNSLSTLLLRISQESYNEMGALLQKMADIPIGPTTNGSFANGLIAANSQGNAEASKRKKLLLLQFAQEQRAKFIKLLVLTEWGKKAAKDLTRLIDLFRWASEQAQYMEAADYKLDRIKVQSNNARENSPDIATALEVLSTGKASWMPSLGYIPPEPVSSDEALKLLRYMNTSLSIRLNVHENLPRHLRNWRIHSGRATFVIENELEFDVMSFVEDASEQWFLIDVRLMFTPAPTITVGSRFFMQLKLQADFVLKDKGLSGLFDFLNNFILTHKISVLRSQAVGLVRAGWAGSLKVEPVHRLLVVSYWTNRPGKKNWIEIGISSNRPKDGKVSWRGQPVPSLSTRWFRQGKEVKDANLKFDWNSLSFEKVIKLVIARHTSDILRSTKEKLKSGVMAAAHLSETEPADCTLAATLGTKSTSMTLSLEPVTGNFIMRPASALSARAENAFNQGREPEKMADVITQVLAGTLHTLIQKIAQQLGWQPVARQSLRPQVVTAAVKLDVISSTLYCPRGWPSSWALAAVIDSSGESWWVFEIGATGDSIKTALQIKMDRPDGSSLPINRKTLSSIGRVAVQVISFRATASRLARERKTCSLQTELGQVGGIESRRIARRWVLHLQTPHLLVETPGQDAWLEPDIKITCEGLRVQGQTVWHIAAGKMVKGVAADMHKLMAASPQNTFKFSEDGNFRILLSTPFAQDILGELRSRLRDVNRLRTFAATLQKREMRLGSSSLQRVQFQYGPTPYSATVNFSSEQEFSIELSPNNPHHRIHKLLTAIANDQLPSFPSLDSSDSSGLDRFCTTLVLTRPLFKVLREIEQRTPGNYCNPAIHVHSILKYRITYSNPVCTFDIRLQHKGDNVHWVLEDNLRPKDANLLPTPERGQGHRRLNVLQAKLKTLFSEKGTGWFGTRNGMVTDLDAIPDALRKLDEVVLSCKMEGGYVAPPPLVQQQAQNAGHALGQAVAQANGPQQQQARMQQQQQQQQQQQARQQQQAQHNQQQARRQQQSQQNQRGQQQPNGRPSQQHMPNGRQQMQQQQQHRGGRPGQNQNNVIEID
Length1110
PositionTail
OrganismPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Pyrenophora.
Aromaticity0.06
Grand average of hydropathy-0.473
Instability index50.68
Isoelectric point9.65
Molecular weight124048.62
Publications
PubMed=23316438

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP24943
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.01|      32|      55|    1004|    1052|       1
---------------------------------------------------------------------------
 1021- 1052 (64.34/42.59)	ANG.P.QQQQARMQQQQQQQQQQQARQQQQAQHN
 1072- 1105 (55.67/16.76)	PNGrPsQQHMPNGRQQMQQQQQHRGGRPGQNQNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.56|      47|      55|     432|     485|       2
---------------------------------------------------------------------------
  432-  485 (71.34/68.03)	IARHTSDILRSTKEKLKSGvmaaahlSETEP.ADC...TLAATLGT..KSTSMTLSLEPV
  490-  542 (67.22/48.39)	IMRPASALSARAENAFNQG.......REPEKmADVitqVLAGTLHTliQKIAQQLGWQPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.73|      43|      52|      37|      81|       3
---------------------------------------------------------------------------
   37-   81 (71.77/54.57)	PKGPTPEHYEEPPEIehVGDEQYNSLST.....LLLRISQESYNEMGALL
   88-  135 (65.96/43.18)	PIGPTTNGSFANGLI..AANSQGNAEASkrkklLLLQFAQEQRAKFIKLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.22|      28|      48|     553|     580|       5
---------------------------------------------------------------------------
  553-  580 (51.59/26.85)	TA.AVKLDVI.SSTLYCPRGWPSSWALAAV
  602-  631 (39.63/19.19)	TAlQIKMDRPdGSSLPINRKTLSSIGRVAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.50|      10|      15|     137|     146|      16
---------------------------------------------------------------------------
  137-  146 (17.34/ 7.93)	LTEWGKKAAK
  154-  163 (18.16/ 8.63)	LFRWASEQAQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24943 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MNHSASNAAAASRDGDIKKRAHDGSLTNGASTAIATPKGPTPEHYEEPPEIEHV
2) VAPPPLVQQQAQNAGHALGQAVAQANGPQQQQARMQQQQQQQQQQQARQQQQAQHNQQQARRQQQSQQNQRGQQQPNGRPSQQHMPNGRQQMQQQQQHRGGRPGQNQNNVIEID
1
997
54
1110










Molecular Recognition Features






MoRF SequenceStartStop




1) RDGDIKKRAHD
13
23