<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24939

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMESVVDEWKAFLSRCIASRIPPDVFAAAVAQLHAKSPLPGRKLAALVLLPRAAGIDPRSIAILEQLLALKKVDASDVLTVTFLHSKDRRPINTGDEKAPKDAQWSNPPELEEIIFHRLHKAFASEERPVNNTEGLRTLIVVTRWMQVMVTSHTSDTMIQAMAGIQQPHQQSINAREGLAMLVIGVIENPRILAILSNPKGKDVRKNFVQSLSSFIPFLHNNSAGSQTSLSLANRLEMSQKQHDFFEKLPNVNGERNESTGLEVAALQLDAVMELPQVNTRPGLYVFLNALLVARPLTDDFTIISHLHSRYKVGYPLGIPQGSDLQQLEPQNMATDLITAAFDILANAMYRNEQSETLFYLKSFLINKVPILLTQLSGSIFPMTVEMCITQALSHVDPHAFPSFSQGFDDIMGSNNSLSDVRQDFLNACALHGLIAAGTVERLLGEAPMQGPPAKRYERKELLNQCKTNFDKISLYIDELENVDGNAGAIVAAVTDFIAHLCETQTTMYLKQLSCLIFRKPQAMDVMLQFTSPPSILRPLCQFLDDWHYDSDQGEHQPVYDEFGAILVCIMTFMYRYDLTYHDIGIGHDSFVAKLMQRGHHGMLPDELTEEQGKHLGNWLKGLYDSDKEGLSNEVFASCRPQEFYLTVPTLFRQTVVACSTGVLSFETVKGGLEYLGETFLLPSLIGGLTWMASYALLQTHNDLDAMIRIFNEVILSSPTSGDAQAMHSTIIAIVSSRLEKCFRTLQRREPNRTTLEPFIQAIKAHSHYERTAYATLKELDQWTNVPHSTLNTSLRHTVQQLSQWASTASLQPNPPSYTHRQIYASLKMLGATRTLRAIVEEVKNQTDAGNGAAALDIGISIICAPMVEDSPVSVDWVASQIVAPAPQRTRMNLREILKQEFDCAANLVATDPLTAETIVRLHRRVEAHFASLSETGLQAPPINIPSVHIGDMQSQTISDDLNRAIDDAAAASIVEDISNMDNKALQRSMDELTASEGLDLSSIGMGNGDSGTGDMGTDLGNLPDLDLGDMGSMGMDMDMDMGMGGGGGDDDWGLDFDNM
Length1059
PositionTail
OrganismPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Pyrenophora.
Aromaticity0.07
Grand average of hydropathy-0.142
Instability index41.81
Isoelectric point5.09
Molecular weight116907.86
Publications
PubMed=23316438

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24939
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.14|      17|      17|     993|    1009|       1
---------------------------------------------------------------------------
  993- 1009 (29.83/16.69)	TASEGLDLSSI.GMGNGD
 1012- 1029 (26.31/13.87)	TGDMGTDLGNLpDLDLGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.61|      12|      17|     670|     681|       2
---------------------------------------------------------------------------
  670-  681 (21.63/13.49)	GGLEYLGETFLL
  686-  697 (22.98/14.79)	GGLTWMASYALL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.43|      15|      18|     808|     822|       3
---------------------------------------------------------------------------
  808-  822 (28.95/20.89)	ASLQPNPPSYTHRQI
  824-  838 (24.47/16.40)	ASLKMLGATRTLRAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.01|      18|      19|     765|     782|       4
---------------------------------------------------------------------------
  765-  782 (33.46/25.58)	HSHYERTAYATLKELDQW
  787-  804 (32.56/24.68)	HSTLNTSLRHTVQQLSQW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     441.30|     127|     148|      96|     225|       6
---------------------------------------------------------------------------
    4-   95 (67.90/42.31)	................................................VVDEWK..AFLsrcIASRiP.PDVFAAAVA...QLHA.KSpLPGRK.LAALVLlpraaGI..DPRSIAILEQLLAlKKVDASDV..LT......VTFLHSKdrrpiNTGD
   96-  225 (208.91/161.54)	EKAPK.DAQWSNPPELeEIIFHRLHKAFasEERPVNNTEGLRTL...IVVTRWM..QVM...VTSH.T.SDTMIQAMAGIQQPHQ.QS.INAREGLAMLVI.....GVIENPRILAILSNPKG.KDVRKNFVQSLSSF....IPFLHNN.....SAGS
  246-  378 (164.50/116.98)	EKLPNvNGERNESTGL.EVAALQLDAVM..ELPQVNTRPGLYVFlnaLLVARPLtdDFT...IISH.LhSRYKVGYPLGIPQGSDlQQ.LEPQNMATDLIT.....AAFD......ILANAMY.RNEQSETLFYLKSFlinkVPILLTQ.....LSGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.43|      30|      74|     526|     559|       7
---------------------------------------------------------------------------
  526-  559 (53.55/47.65)	MLqftsPPSILRPLCQFLDDW...HYDSD.QGEHQPVY
  562-  582 (24.58/11.19)	......FGAILVCIMTFM..Y...RYDLT.YHD.....
  602-  635 (42.30/27.32)	ML....PDELTEEQGKHLGNWlkgLYDSDkEGLSNEVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.70|      10|      16|     856|     865|       8
---------------------------------------------------------------------------
  856-  865 (19.31/11.78)	DIGISIICAP
  875-  884 (19.39/11.86)	DWVASQIVAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.41|      13|      15|     949|     961|       9
---------------------------------------------------------------------------
  949-  961 (22.39/16.11)	IGDMQSQTISDDL
  965-  977 (20.02/13.54)	IDDAAAASIVEDI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24939 with Med5 domain of Kingdom Fungi
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