<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24918

Description Mediator complex subunit rgr-1
SequenceMASSGCPWLAQSATSSSPVPELLHEPEVLPDATGCPRLLVCLPRKTDMERKIEIYNFSASTRQLFIRLLALVKWANSASKVDKSAKIMAFLDKQSLLFIDTADMLSRMARETLVNARLPNFHIPAAVEILTSGTYSRLPSIIRERIVPPDPITPSEKRQTLQRLNQVIQHRLVTGNLMPQLRKFKIENGRVTFKVDHEFEVSLTVMGDGPNIPWRLLDIEILTIKRFAKQLAILHIPSIGNKEVDIADRAVRSDLLSMERLLVHTVYVRSLSRLADLKSELQLFLPDVDYSILGTPAMLMVPILNPCLRAEQIYITVDTHTGMLRCHVPKHLDCPIMAEMQHALNNDRSRLQHLFSELRYWITQRRCEKTLQHLPATTQERLPLVFPQGHAIEKVGPHKVYIQLYRHSNVILIVELKEKDSSPNEMTYTFYLVLVKPSSVEDSQSQDAEPTTSISQSGPGSVPPGGPPSVPGLSSSAAHPPNSSSATENDGMPKMYLKVQSLIEFDTFVATHGPGTYVDELAGSKRKLSALGEGPSKQQKVIYPAYFIPELAHVVAMCDEKLPFVALAQELTRRRIPHGGLQVEANATSLVLKLLTLPQPKAPLVPVSATAAAAGQQGGPDQKPPEPKLVSVPRIEKDVWNALLRRLLSVSVRAQVNKGNQTRLWTTELVFYGSPLTSTHHKEQGMRRAVYLQYDMSPVDAVDRIVDMILNDWSKIVYLYTLVHDFREQIDKYNLQNIVTIKSYSYTSLLLAYGPNKEVNVNIYWDIEAKEFKMVFTGGNNAINAHSMMRDQLQAHLNHNYDLAQIVHLLHETYQPLSSIAKLPIIPHLAILQSPKIPVLSFCIIPQSPTLLRISFQGVYCLEIRLRGSGLCSIRDGAYSRFDRSHVVEEFTPTQGLKGFLSKYVDETAVYRRRSQSEDDNPPSPITMEDPHGGPASVGSTFLSGGSMRGPQSPRDPGLRFAAPLTPPSGSNPHTPASPHPQGMGGGGSQNHPNFNMTSPPAPHMPHPSPSGGLMPSSPLNPQPSPMAHSPGPSNMPYMGGQSHTDGSPFTAAHSPAASNWPGSPGMPRPSPRPGQSPDHKAQTPHHNTSRVLPARSWAGAIPTLLTHEALDTLCRATAHPQKEIPGPELSPLERFLGSVFMRRQLQRIIHQEENQLQAITSNEPGVVLFKADNLQYQVFLNPNHMQSLHMKVSQAPQMAPTMDGKPPYQWSPEDLQALEQFFDQRVAAPPYRPAVVTSFTRMLNLSAQVMKDMIQIMRLDLMPEMGQGNKWNVQFILRMPPSATPIVPVGTTTILSHRQKILFFIQITRVPYLPNMEWKDCVTMLLPMVYDMTVNHTQLAERREQNVPQLTSAVSAHLRRFAECTVLPPGECSLFPAVRDLLMNLTLPNEQPPPGQMPNQIGPMGAMPPGGPGQIAPSPVGSSPNPMMHSPMQMGGAGGQQYAGMAGAGPGGPGQGGAGGPN
Length1463
PositionTail
OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Culicinae> Culicini> Culex> Culex.
Aromaticity0.06
Grand average of hydropathy-0.285
Instability index59.78
Isoelectric point8.74
Molecular weight161532.11
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24918
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     118.52|      24|      24|    1001|    1024|       1
---------------------------------------------------------------------------
  456-  480 (26.87/ 6.28)	.QSG.PGSVP.PGgpPSVPGLS..S.SAAHP
  967-  989 (27.65/ 6.69)	PPSG.SNPH.tPA..S..PHPQ..GmGGGGS
  990- 1015 (35.87/11.01)	QNHPnFNMTSpPA..PHMPHPS..P.SGGLM
 1016- 1041 (28.13/ 6.94)	PSSP.LNPQPsPM..AHSPGPSnmPyMGG..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     148.22|      23|      24|    1393|    1415|       2
---------------------------------------------------------------------------
  600-  622 (37.11/14.57)	PKA.PLVPVSATAA..AAGQQGGP.DQ
 1393- 1415 (52.30/23.88)	PPP.GQMPNQIGPM..GAMPPGGP.GQ
 1418- 1441 (28.59/ 9.35)	PSPvGSSPN...PMmhSPMQMGGAgGQ
 1442- 1456 (30.22/10.34)	QYA.G........M..AGAGPGGP.GQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.83|      24|      27|    1075|    1100|       3
---------------------------------------------------------------------------
 1051- 1079 (25.55/10.81)	TAA.HSP........AASNWPGspgmprpsprpGQS..PD
 1080- 1104 (31.68/21.16)	HKA.QTPHHNTSRvlPARSWAG..............aiPT
 1108- 1132 (27.60/12.33)	HEAlDTLCRATAH..PQKEIPG..........pELS..P.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.14|      25|      28|     124|     150|       4
---------------------------------------------------------------------------
   99-  120 (21.41/ 9.01)	.....IDTADMLSRM...ARETLVNarlPN
  124-  150 (39.12/31.13)	PAAveILTSGTYSRLPSIIRERIVP...PD
  154-  173 (28.62/15.71)	PSE....KRQTLQRLNQVIQHRLV......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      28.42|       8|      26|     922|     933|       6
---------------------------------------------------------------------------
  922-  933 ( 9.61/15.78)	PPSPitmEDPhG
  951-  958 (18.81/ 8.00)	PQSP...RDP.G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.72|      28|      30|    1138|    1165|       7
---------------------------------------------------------------------------
 1138- 1165 (48.72/32.48)	GSV.FMRRQLQRIIHQEENQLQAI...TSNEP
 1166- 1197 (40.00/25.29)	GVVlFKADNLQYQVFLNPNHMQSLhmkVSQAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.67|      14|      75|     272|     285|       8
---------------------------------------------------------------------------
  272-  285 (23.38/15.71)	SRLADLKSELQLFL
  349-  362 (27.30/19.67)	SRLQHLFSELRYWI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.17|      22|      25|     700|     721|      10
---------------------------------------------------------------------------
  700-  721 (39.49/30.21)	DAVDRIVDMILNDWSKI.VYLYT
  725-  747 (33.68/24.67)	DFREQIDKYNLQNIVTIkSYSYT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.51|      20|      28|     401|     423|      12
---------------------------------------------------------------------------
  401-  423 (29.15/35.49)	YIQLYRHSNViliVELKEKDSSP
  431-  450 (33.37/28.83)	YLVLVKPSSV...EDSQSQDAEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     187.12|      60|     460|     802|     866|      16
---------------------------------------------------------------------------
  802-  866 (92.96/66.48)	DLAQIVH..LLHETYQ............PLSsiAKlPIIP.HLAILQSPKIPVLSFCIIPQSPTLLRISFQGvyCLEIRL
 1253- 1327 (94.15/52.57)	DMIQIMRldLMPEMGQgnkwnvqfilrmPPS..AT.PIVPvGTTTILSHRQKILFFIQITRVPYLPNMEWKD..CVTMLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.98|      10|      28|     210|     219|      17
---------------------------------------------------------------------------
  210-  219 (20.22/12.27)	PNIPWRLLDI
  237-  246 (17.76/ 9.82)	PSIGNKEVDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.46|      24|     385|     504|     527|      19
---------------------------------------------------------------------------
  504-  527 (43.24/24.57)	EFDTFVATHG.PGTYVDELAGSKRK
  890-  914 (38.22/20.92)	EFTPTQGLKGfLSKYVDETAVYRRR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24918 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EDSQSQDAEPTTSISQSGPGSVPPGGPPSVPGLSSSAAHPPNSSSATENDG
2) MNLTLPNEQPPPGQMPNQIGPMGAMPPGGPGQIAPSPVGSSPNPMMHSPMQMGGAGGQQYAGMAGAGPGGPGQGGAGGPN
3) VYRRRSQSEDDNPPSPITMEDPHGGPASVGSTFLSGGSMRGPQSPRDPGLRFAAPLTPPSGSNPHTPASPHPQGMGGGGSQNHPNFNMTSPPAPHMPHPSPSGGLMPSSPLNPQPSPMAHSPGPSNMPYMGGQSHTDGSPFTAAHSPAASNWPGSPGMPRPSPRPGQSPDHKAQTPHHNTSRVLPARSWA
441
1384
910
491
1463
1099










Molecular Recognition Features






MoRF SequenceStartStop




1) YAGMAGA
1443
1449