<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24909
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MLTQNSSKTLAISVRCPVIANDEEINQLQKQLKEAEYILATSIFQARQKLTSFAKATKRPVSSDELIKFAHRKNASNAICAPLTWQQGDQRRPYPTDRDAAELPLQFRPDHQRAPESGQTEQSRRN |
Length | 126 |
Position | Middle |
Organism | Culex quinquefasciatus (Southern house mosquito) (Culex pungens) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae>
Culicinae> Culicini> Culex> Culex.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.856 |
Instability index | 60.23 |
Isoelectric point | 9.51 |
Molecular weight | 14334.97 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP24909
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 68.30| 20| 35| 58| 92| 1
---------------------------------------------------------------------------
69- 91 (31.51/40.15) FAHRKNASNaicAPLTWQQGDQR
94- 113 (36.79/11.56) YPTDRDAAE...LPLQFRPDHQR
---------------------------------------------------------------------------
|