<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24898

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTLIKFMKDLVPKLHDHYHQGPVQEKPLNSSSSTGPAGAMTPNSSLNTNSSTIPPPLSSPAGSLHSPASASLSGSASQNQPPPSPQEEQKLAQKQWSYCTQLCKYMYEEGLLDKSEFLNWVLDLLDRMKSSPSSDDGILKIYLPLAMQYLPDFVQSERFCRRLAYAVCKKLAHLINTMADSHNLCLADTGIKPKQETSEQKDKSSKTAKDCDTKLEIAPLQVNPFETIFSEFMSCSHHHDLFLQLSAIIQVITLECPTALVWCGVGETRSSSVLAGSPLDHLPVAPSSLPMPSRHAESRWCVDKWQTAAGNASLKILSVLDALDGHCFFRMDTNNSLDTLYQKIFPPLQLQKESPNNNASESKDGSNKMLEYDVEQDSSIVKILCEWAVSWQRWGEHRAMAVAWLLDKRQSEIFSTYENDSGNNANSSDDKDSVISGGGTGLPVFQNILMTFLDNDAPISEENGTIQSKSQFTNLVHLFSELIRHDVFSHDAYMCTLISRGDLLTGTGMSLSDTQPSCQTGLGTGPISNKPASSSPNINQGIEEDVMQTDFKAKLEDLDDSNVDDDLDKLLQHIKEDQQNSMDAPDSPKDPEHATAPVTSTVSNKTESSSRHFLYTEHFPLSQDDPISLHDCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRNEFNFEATSNKCQSMSYFDQHVVTWQCAVQVQEMLNSFSLGNSNYLPVQEHVAFLFDLMESAFNIYGLIDTCIQILKELPEVELQLMSKSSVLVKSYTTSLSLYVVGVLRRYHCCLLLSPEQTIAIFEGLCRIVKHVSNPSDCSSAERCILAYLYDLYSNCASLKTRPQQEPFHNAYPKIKQALYTPLQPTPSAHSYNAQFMADIIASPRRGGRIEQIWARQLNESASNRYSFVCNAVIAVTRDIDNDTLNDIAVMCSELTACCNALSTEWLGALIALCGSSKDAGYYVDLITQVNIQNSAIHNALSVFTSILVARHCFSLENFIGYVALPALVQACKGRSESTPEIEAGARLSCHLLLRLFKTVECPQPGLYSVSTSPNPITTVGQAHNIKLSCDRHLLAAAHQNIGVAPVLAVLKGILVVGDATAQKTQTSIFSTGKRSGLNTPVHPGSTPKHAGDLSHILGTSDLSILGNTDESMLDLTPSNANQDSTASLSDFAQHVLRQICSQEWVLERCLQNAEELCQQGMLIDNMLTAKQAQRLLHMICYPENESNLIAEMDQKAIIVRILENLEQWSLRISWLDLQLMFKQTNCTPELSNWLDMVARAAIDVFQVQDCNVMRSLLEGPGKQEKAKSSMWLVAPLVARLPSAVQGRILKVSGQVLESTNMFSKTKENAGGNNSSIGSQGGNSNSSISSNGSVMASKQSTHLNHQPFLGLVLTCLKGQDEQREGLLQSLYAQLSQFLQNRDVETIGGIEDPLGFEKMLDALQLRYSLVGGLFDAIQKNSTSTSDWSILFAQLISQGVIDLSNNSELFTTTLDMLATLIHSTLVSDSSQSERDETKKQYTNLMKKLRKELGDKNNPSIKYVRQLLPLAKQTCEVIACEPAGSSTDAKGNKINIDSIEKKHGLRLADKQRVSVWDLLEGHKNPAPLSWAWFGAVKIERKPLAYEETHRLLKYHTHSLVKPSSYYYEALSLPPEDLEPLPDKSKDDMKADTPTSDQSPAPAGKKGKSQGRKRKPKGGSTPQTSQQAGQLQGMSGQPGAPVQANQQQQQQQQQQLQQSQQQQQQQHPMTMTPQQTMQQLQNANLGQMPMGSHMGQMNPQTMQQHYPQQNPNQMLSQQMAQQQNMGQGNQVGGMGGMMGGPQQHSMTHSMPMGGQVGAGGGGNQWGGYNTMQQPQQAQQPMYYNQGMGQPGMNRFDRPQLNTNPKQVLSNMLRARLPTNPGFLPQQAQRNPQQPFMRGPLRPSLPNQLAGTATGGAMIGHSGGSMIQTNLLNQQNTGNGNSGGMANPNMMGMQNMQQNMPNNQGIGMQNMQQGGNIGNAGIGGNNMMGGPGMFQGQGGPYQNTNQNYSNYGNQGIVQQGGQGMMGNFNQMGQQQRNSQAEYIAQQRALAARSNQYGQHAPNVTMNNIINQGAVPPYPRQGGKPASAAVAQNQQQFQQQRLRQQMLMQQQQQQQQQQQQQGMGQQGNTQGMVQNQGQGINPQQTPNLVAQLQRQIPNQANMMNQQYSHQPPPY
Length2232
PositionKinase
OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Culicinae> Culicini> Culex> Culex.
Aromaticity0.06
Grand average of hydropathy-0.513
Instability index50.49
Isoelectric point6.45
Molecular weight246119.24
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24898
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.89|      19|      19|    1763|    1781|       1
---------------------------------------------------------------------------
 1763- 1781 (35.29/11.47)	QANQQQQQQQQQQLQQSQQ
 1816- 1829 (25.69/ 6.33)	QMNPQTMQQ.....HYPQQ
 2171- 2187 (29.91/ 8.59)	QQQQQQ..QQQGMGQQGNT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     128.08|      19|      19|    2022|    2040|       2
---------------------------------------------------------------------------
 1794- 1809 (22.74/ 6.87)	QQ..TMQQL.QNANLGQMP
 1883- 1900 (29.07/11.36)	NQWGGYNTMQQPQQ.AQQP
 2022- 2038 (30.97/12.71)	NQGIGMQNMQQGGNIGN..
 2072- 2082 (21.62/ 6.08)	NQGI....VQQGGQ....G
 2129- 2147 (23.68/ 7.54)	NQGAVPPYPRQGGKPASAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     721.14|     243|     288|    1091|    1375|       3
---------------------------------------------------------------------------
  458-  553 (51.64/18.82)	.....GNNANSSddkdsvISGGGT.........GL...P...VFQNILMTfldNDAPISEENGTIQSKSQFTNL...VHLF.SelirhdVFSHDAYMCTLISRGDL..LTGTGMSLSD...TQPS.....................................................................................................................................................................................................................
 1100- 1375 (352.55/399.62)	PITTVGQAHNIK......LSCDRHLLAaAHQ..NIGVAPVLaVLKGILVV...GDATAQKTQTSIFSTGKRSGLNTPVHPG.S......TPKHAGDLSHILGTSDLsILGNTDESMLD...LTPS......NANQDSTASLSDFAqHVLRQICSQEwVLErcLQNAEELCQQGM.....LIDNMLTAKQAQrllhmicyPENE......SNLIA....EMDQK...AI.IVRILenleqwslriswldLQLMfKQT....NCTPELS.........NwLDMVARA.AIDVFQVQDCNVMrSLLEGPgKQEKAKSSMWLVAPLVARLPSAVQG..RILK
 1400- 1674 (316.95/245.88)	SIGSQGGNSNSS......ISSNGSVMA.SKQstHLNHQPFL....GLVL.......TCLKGQDE.....QREGLLQSLYAQlS......QFLQNRDVETIGGIED..PLGF..EKMLDalqLRYSlvgglfDAIQKNSTSTSDWS.ILFAQLISQG.VID..LSNNSELFTTTLdmlatLIHSTLVSDSSQ........SERDetkkqyTNLMKklrkELGDKnnpSIkYVRQL..............LPLA.KQTceviACEPAGSstdakgnkiN.IDSIEKKhGLRLADKQRVSVW.DLLEGH.KNPAPLSWAWFGAVKIERKPLAYEEthRLLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     137.58|      22|      24|    1956|    1977|       4
---------------------------------------------------------------------------
 1850- 1866 (22.78/ 6.30)	.QVGGMGGM...........MGGP...QQHS......M....
 1947- 1968 (34.72/14.18)	AQRNPQQPF...........MRGP...LRPS......LPNQL
 1969- 1995 (22.44/ 6.07)	AGTATGGAM...........I.GH...SGGSmiqtnlLNQQN
 2039- 2062 (32.98/13.03)	AGIGGN.NM...........MGGPgmfQGQG......GPYQN
 2063- 2094 (24.67/ 7.55)	TNQNYSNYGnqgivqqggqgMMGN...FNQ.......MGQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     472.40|     148|     202|       2|     203|       5
---------------------------------------------------------------------------
    2-  162 (232.77/144.69)	QRAAWFIK.LSSAYTVAVSEAKIKKRQmpdPATEWTGTLIKFMKDLVPKLhdhyHQGPVQEKPLNSSSSTGPAGAMTPNSSLNTNSSTIPPPLSSPA.....GSLHSPASASLSGSASQNQP..PPSPQEEQKLAQKQWsyCTQlcKYMYEEGllDKSEFLNWVLDLLD
  205-  360 (239.64/169.61)	KKLAHLINtMADSHNLCLADTGIKPKQ...ETSEQKDKSSKTAKDCDTKL....EIAPLQVNPFETIFSEFMSCSHHHDLFLQLSAIIQVITLECPTalvwcGVGETRSSSVLAGSPLDHLPvaPSSLPMPSRHAESRW..CVD..KWQTAAG..NASLKILSVLDALD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     219.79|      70|     324|     376|     450|       6
---------------------------------------------------------------------------
  376-  450 (114.44/90.96)	LYQKIFP.....PLQLQKESPNNNASESKDGSNKMLEYdveQDSSIVKILCewAVSWQRWGEHRAMA..........VAWLLDKRQS..EIF
  699-  785 (105.34/69.13)	LFSKKFSidvaeGGKVKKHSRNEFNFEATSNKCQSMSY...FDQHVVTWQC..AVQVQEMLNSFSLGnsnylpvqehVAFLFDLMESafNIY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.19|      14|     203|    2007|    2021|       7
---------------------------------------------------------------------------
 1910- 1923 (25.19/12.11)	PGMNRFDRPQLN.TN
 2007- 2021 (24.00/16.39)	PNMMGMQNMQQNmPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.60|      27|     286|    1901|    1946|      14
---------------------------------------------------------------------------
 1901- 1941 (41.80/14.51)	MYYNQGMG.QpgmnrfdrpqlntnPKQV..LSNMLRARLPTNPG
 2190- 2219 (38.80/15.51)	MVQNQGQGiN..............PQQTpnLVAQLQRQIPNQAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.98|      12|      88|    1745|    1757|      15
---------------------------------------------------------------------------
 1745- 1757 (19.48/12.23)	SQQAGQLQGMsGQ
 1836- 1847 (24.50/11.41)	SQQMAQQQNM.GQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24898 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLDKLLQHIKEDQQNSMDAPDSPKDPEHATAPVTSTVS
2) GMSLSDTQPSCQTGLGTGPISNKPASSSPNINQGIEEDV
3) HDHYHQGPVQEKPLNSSSSTGPAGAMTPNSSLNTNSSTIPPPLSSPAGSLHSPASASLSGSASQNQPPPSPQEEQKL
4) LSLPPEDLEPLPDKSKDDMKADTPTSDQSPAPAGKKGKSQGRKRKPKGGSTPQTSQQAGQLQGMSGQPGAPVQANQQQQQQQQQQLQQSQQQQQQQHPMTMTPQQTMQQLQNANLGQMPMGSHMGQMNPQTMQQHYPQQNPNQMLSQQMAQQQNMGQGNQVGGMGGMMGGPQQHSMTHSMPMGGQVGAGGGGNQWGGYNTMQQPQQAQQPMYYNQGMGQPGMNRFDRPQLNTNPKQVLSNMLRARLPTNPGFLPQQAQRNPQQPFMRGPLRPSLPNQLAGTATGGAMIGHSGGSMIQTNLLNQQNTGNGNSGGMANPNMMGMQNMQQNMPNNQGIGMQNMQQGGNIGNAGIGGNNMMGGPGMFQGQGGPYQNTNQNYSNYGNQGI
5) QGGQGMMGNFNQMGQQQRNSQAEYIAQQRALAARSNQYGQHAPNVTMNNIINQGAVPPYPRQGGKPASAAVAQNQQQFQQQRLRQQMLMQQQQQQQQQQQQQGMGQQGNTQGMVQNQGQGINPQQTPNLVAQLQRQIPNQANMMNQQYSHQPPPY
602
544
51
1691
2078
639
582
127
2075
2232










Molecular Recognition Features






MoRF SequenceStartStop




NANANA