<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24891

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMARANPWEHGEKGSWEAGLSYECRSLLFKALHNVIERSLHLSFSFAFFVHGDSTVCASMDIREHPPVRPLMLKHLEEAQAHQGGGDSPKPRSVILAPFGLAGTLTGQSHKASDPQTQKVLDDWSAFYPISNKNMHLAAESVGGGGDLVPPIVEIMTGKSNQNCGAGGSTPYGGPPSYCRNPLSIGDSHPLPSEGSPASAAPSPMQSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPSCLDHLDKNTPAPTPTDQHDSKSITASPYHTPSHPGGGGGSGGVMSVETPNSQQSGGGQQQNVQNALQTAAGGGQQTGLSSTSSSSSGGTTNSSPGNLPSHGGGGGVGMAGIKCEVMPGTTPSVYSSLNPIANQSPVNKREAMLQILQSLKRPSLSSRDYEEIAGEDCIPSTSQALYDYSSIDAWMNHPVKRYRPNEESKLAQQIRHMDLYADQKHSEKYLATVQSVADGVKQDPQDPLALPDERDSTPGPGSMLNESQIKTEAGCERSGGGQDGEGDDQMLGAHEIKKEKEDKDDRLYTVQGLQPNLDDLENLFDDSANYHDDPDMNANTSPASNKSGNMEDIKRFTGCGTGTGHTGILSPKELSQMFPTPPSLEHHPNSSPGAGGFLSDGIVIDTMVESAATAIPILGSPQEEPIDDWSYVFLPPPICKYVGSSKYAPLQQLPSQLTQPQVTLPLNCVYKSSSQLRKEKQEREKLIKLRELQEQQEAAQQQQQQQQQQQQAQVENIPPNANTNATSNVMMKQEPVLTVPQPLSSAPNSLNFNGNAGGGIGNPYSNPPSQGVLSRPPSVNSLMSPSPMNNGGGGGAMMNNNMFHPGMLRQGMSPISPATPGGGTPAMRVPTPQGSCPLPYPSPLGAAGSPGNPMNFRRTPILPPPPYDVAVASPATSTTSSYHAKQFGPDDGAEPATPSAPEVASNNPSLQQRLVTAIETSALLVNVLLYDTSLNIFRDHNFTSCTLCVCNAGPKCVGNIRGADSGPYLALPGTSFLGGSSKGGSAKSTPSQFNGGNNNNNGAFEMMNSPAVAINGGNSLQNGYLDEDPIKCTCGFSALVNRRLAHRAGLFFEDELEITGMAEDPALHKKGSLLEFLLGKGAEASGVSCDSSPLPLRIMDLLRQHCAVIQSSSNSIHRAVARFRSAMTVKSMANATVHMLEYSDANDVISLALEQSRLQAISETKPEQETALVKTSGNVHKWPYLRAGGPKSNQDIVRIMKSMQPLLQDAFHKKCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPVPSLVVGYEKDWLSLSPYAIQYWDKLLLEPYSYARDIAYVVVLPDNDFIVSRVKTYFKELSTTYEMCKLGRHNPIKGWDGVLRVSSNRVLKETQNSNADEWFTSLGDSRLSDLLKLYAQTCQQQLAPYLSKRPAQRPTETAKVLMPPPPPSTPDPSQPGDKAPSTPKSDNDADGSMLNTSSSSSPADRMQHDDDGKEPPHIVLYMVEPFTCGTDKPETERLACLSLLRCYSNILNQVPDSIRSNISVQLISLESILELGRSRNRLRLSDHMRCQALSIFSQSRRFMAHANNVKSLTGFGTAANADAFIKNKDEKNRTPYKLYTPPYVLAKLTEKKENTESFGQTSIKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRVRRKRASARRSGLQKLMDFILGLISQTVQPWRIVIGRVGRIGHGELKGWSWLLSKQNLQKASKHLKEICEQCSLMHPVSVPSILSACLVTLEPDSALRVMPDQFTPDERFSQLSMQSPLTTPQDVTCTHILVFPTSARTQSAQSAFVEQHINDDEFGLELEGNLEGLGLDGECDEDGINGLGDLFDNWDDLPTQQLMQNDSRQGSPSPFEGQRHSPGDSGSNCAQNMNGFMAQEAEDVGSLAQQPMAIGYLVSTAPTGRMPPWFWASCPHLENVCPVFLRIALHLNSFQILQNNDDPMAQSQSTTEHPLDSNITADVLRFVLEGYNVLSWLAMDSNTHDRLSCLPVHVQVLMQLYHMTAALA
Length2034
PositionMiddle
OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Culicinae> Culicini> Culex> Culex.
Aromaticity0.06
Grand average of hydropathy-0.494
Instability index58.99
Isoelectric point5.65
Molecular weight220193.53
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24891
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.14|      26|      28|     815|     840|       1
---------------------------------------------------------------------------
  191-  214 (29.79/ 7.33)	PSEgSPASAA...PSPMQSSVSQP.T..SV
  815-  840 (49.23/16.76)	MSP.SPMNNGGGGGAMMNNNMFHP.G..ML
  844-  870 (31.12/ 7.98)	MSPiSPATPGGGTPAMR...VPTPqGscPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.80|      15|      18|     297|     314|       2
---------------------------------------------------------------------------
  297-  311 (26.77/ 8.80)	GGGQQQNVQNALQTA
  313-  327 (26.04/17.20)	GGGQQTGLSSTSSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.20|      17|      18|    1018|    1034|       3
---------------------------------------------------------------------------
  270-  285 (29.68/11.00)	YHTPSH.PGGGGGSGGV
  337-  353 (27.67/ 9.74)	GNLPSHGGGGGVGMAGI
 1019- 1035 (30.85/11.73)	KSTPSQFNGGNNNNNGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.98|      20|      26|     651|     676|       4
---------------------------------------------------------------------------
  651-  676 (30.21/23.79)	GSPQE..EPiddwsYVFLPPPiCKYVGS
  684-  705 (32.76/11.90)	QLPSQltQP.....QVTLPLN.CVYKSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.37|      11|      18|     394|     404|       6
---------------------------------------------------------------------------
  394-  404 (20.46/11.64)	PSLSS..RDYEEI
  411-  423 (14.91/ 6.11)	PSTSQalYDYSSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.36|      20|      26|     485|     504|       9
---------------------------------------------------------------------------
  485-  504 (38.93/21.06)	ERD..STPGPG..SMLNESQIKTE
  508-  531 (25.43/10.95)	ERSggGQDGEGddQMLGAHEIKKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.75|      29|      31|      23|      53|      12
---------------------------------------------------------------------------
   23-   53 (44.32/36.46)	CRSLLFKAlHNVIeRSL...HLSFSFAFFVHGDS
   56-   87 (50.43/31.85)	CASMDIRE.HPPV.RPLmlkHLEEAQAHQGGGDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.67|      11|      18|     985|     998|      14
---------------------------------------------------------------------------
  985-  998 (16.67/15.40)	GPKCVGnirGADSG
 1005- 1015 (19.99/ 9.16)	GTSFLG...GSSKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     317.81|      99|     358|    1329|    1435|      16
---------------------------------------------------------------------------
 1329- 1435 (160.48/130.91)	DFIVSRVKTYFKELSTTyeMCKLGR..HNPIKGWDGVLrvSSNRVLKETQN.SNADEWFTSLGDSRLSDLLklyaQTCQQQLAPYLSKR..PAQ.RPTETAKVLMPPPPPSTP
 1690- 1794 (157.33/106.44)	DFILGLISQTVQPWRIV..IGRVGRigHGELKGWSWLL..SKQNLQKASKHlKEICEQCSLMHPVSVPSIL....SACLVTLEPDSALRvmPDQfTPDERFSQLSMQSPLTTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.11|      19|      25|    1073|    1096|      19
---------------------------------------------------------------------------
 1078- 1096 (33.78/27.75)	HRAGLFFEDEL....EITGMAED
 1100- 1122 (27.33/10.34)	HKKGSLLEFLLgkgaEASGVSCD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.68|      15|     201|     373|     387|      20
---------------------------------------------------------------------------
  373-  387 (27.25/16.31)	ANQSPV.NKREAMLQI
  570-  585 (23.43/12.85)	ANTSPAsNKSGNMEDI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24891 with Med13 domain of Kingdom Metazoa
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