<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24889

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMMHSANGKQQKIEQKVGGPTKMPNSTGTAGPGTAAGIGDKHESWQMELLMERLRSKAKSSHYKSFPEMSKTVRMSLLVRSVKSFVLKLSEDTSGLFISSDMFYLEIILDQNGKVQDVKVHHECKMKQQSCSELVSCLQRGDFVDFTTQLEANNIAKGLFVTLPDQHHCYYMNENKNLEGIVVSSIPFTEPQHVSKILVFLRQQALFNQLLSSCIRNNSSTTRTTDHDQLLVFEVTALSCQYITISLEHPFDESLAMVEFDLRNSLAVQVRVFCNGYESDERISKHISIVVQRTMSIPVTLRALIKIWEEDFEAKFKGKLSSNAGGNGCIDEVNFSLPMGPDDGGGSGPGGGGGGNGLGMNGQHTTGINGSGSSHQEFVDAKKIKYETQDLSKKRRVGEDFRNSPKSNNMEKSLKSEVNVADDDDCDESNNSDSYNSLGGNQTTTTTQHVSSSSASKSSSGKHTPTSPFALGIGEDGFRNKYTGKMNSLNSSPDTILKNSETTDCLEPTKAINQTSASNPEDSNLTVSVTTIEVGKQNMSSSSVLSNINLDKRPGIEIIPLSTSATSIPSSITITPIPVENCAGPSKNSSSDKKLSGSSSSSSSSNRKNSDSKTESDRAKLEKKKKRKHEEHQSQLQMGPPHKILSKNVSTDGPTSPSGGSRRISISPVPPKSGSSSSPRHSPVHHSSPKHQGSYGTSSPKHISGGSSGGGKPSMSALKSAASGGSPNSKSSSGSSTGKDEGSGVFSTGNTSKSSSSSGSSSSRDRDRDRERSDKKSVSNPKLKTPAVKLKQLDLATCGASLSAGVQLELINSNSSGGSSTGSSSIDYTDNSLFASSDMSKNSSVAAASTAGMLLLQQAMKNRKSSLSAVIDKLKSAQSGDESSLMLLPELAQQAGFTLKESSGSNKVASSSSASPTTMVSNIHGHTSSSASATGASSLTNTVAALDTQLSSTTSPVHGKSSEYLVKPSSDGMKLTIQNKKGSKSSLSSSSTNSKSSSKSGLKPGVSSGPGSKKLQSSQSFSGSFSSVSSSSSKSGSSTKSSFQKSNSSSSLSNSSGSLKSSSKSGSSSSSSGSSSKDKARNSSKSSSLISSNAMTLASQAAANAAVNANALNVMKMLGITSSIQNMEGFVKTLDTKFQIPKLSARSASSGNDLDKIKELRAVSAPTTPLQNMSQSPTGINDFSLPFNKLPGDVSPLHSAMLPNVMQKMFAGHDNAMLLRRSPNLEHQASNDGFPSQHGKGSTPPTPTISIPPPFPSPVGLQSHAMDFSNSSDSIDNSNLMLPPTRPSSTMSNHSSSDKLIDATGGNNSMDSFSSSPSAQAIAAAAAQFINKLDNTQQLVAALKNHHLNALSNAAAAAACSSAGSGSVTSPTSVSVHIMKSPAPSPLGMPGNSVDDDLMDDTLVQIGGK
Length1408
PositionMiddle
OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Culicinae> Culicini> Culex> Culex.
Aromaticity0.04
Grand average of hydropathy-0.549
Instability index55.09
Isoelectric point9.17
Molecular weight147401.80
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24889
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.83|      27|      28|    1015|    1041|       1
---------------------------------------------------------------------------
  984- 1024 (32.18/ 7.37)	SSLS...SSSTNSKSSSKSGlkpgvssgpgskklQSSQSF...SGSF
 1025- 1058 (34.06/ 8.34)	SSVS...SSSSKSGSSTKSS..........fqksNSSSSLsnsSGSL
 1059- 1088 (32.59/ 7.58)	KSSSksgSSSSSSGSSSKDK..............ARNSSK...SSSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     559.38|      83|      83|     672|     754|       2
---------------------------------------------------------------------------
  321-  367 (49.52/11.09)	....................................................SNA.....G..........GNGCIDE....VNF....SLPMG..........PDD.........GGG.SGPGGGGG.GNGL...G......MN...GQHTTGI
  368-  450 (70.02/19.10)	NGS.GSS..HQ......EfVDAkkikyetqdlSKKRRVGEDFRNSPK.....SNN.....M..........EK....S....LKSevnvADDDDC.........DES.........NNSdSYNSLGGNQ..............TT...TTTQHVS
  453-  540 (65.49/17.33)	SASkSSSGKHT......P.........................TSPFALGIGEDGfrnkyT..........GK..MNS....LNS....SPDTIL.........KNSettdcleptKAI.NQTSASNPEDSNLtvsV......TTievGKQNMSS
  561-  625 (69.50/18.90)	STS.ATSIPSSititpiP.VEN..........CAGPSKNS...SSDKKLSGSSS..............................S....SSSSNR.........KNS.........DSK.TESDRAKLE......................KKKK
  633-  676 (53.12/12.49)	SQL.QMGP.........P..HK..........ILSKNVSTDGPTSP...SGGSR..................RISISP....V...........P.........PKS.........GSS.S..................................
  677-  754 (130.91/42.90)	......SPRHS......P.VHH..........SSPKHQGSYGTSSPKHISGGSSG.....G..........GKPSMSA....LKS....AASGGS.........PNS.........KSS.SGSSTGKDEGSGV...F......ST...GNTSKSS
  757-  819 (60.59/15.41)	SGS.SSSRDRD......R.DRE..........RSDKK....SVSNPK......LK.....T..........PAVKLKQ....LDL....ATCGASlsagvqlelINS.........NSS.GGS...............................S
  820-  901 (60.23/15.27)	TGS.SS.............IDY..........TDNSLFASSDMSKNSSVAAASTA.....GmlllqqamknRKSSLSAvidkLKS....AQS.................................G.DESSLM...LlpelaqQA...GFTLKES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.85|      23|      28|    1250|    1272|       3
---------------------------------------------------------------------------
  925-  951 (21.95/ 6.24)	HTSSSASATGASSltntvA........ALD.TQLSS
 1250- 1272 (41.20/19.28)	IPPPFPSPVGLQS.....H........AMDFSNSSD
 1281- 1310 (25.69/ 8.78)	LPPTRPSS.TMSN.....HsssdklidATGGNNSMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.61|      12|      28|     972|     983|       4
---------------------------------------------------------------------------
  972-  983 (20.30/ 9.41)	MKLTIQNKKGSK
 1001- 1012 (21.30/10.28)	LKPGVSSGPGSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.92|      14|      15|    1321|    1334|       5
---------------------------------------------------------------------------
 1321- 1334 (22.56/15.33)	IAAAAAQFINKLDN
 1339- 1352 (23.36/16.14)	VAALKNHHLNALSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.92|      22|      47|    1120|    1142|       6
---------------------------------------------------------------------------
 1120- 1142 (34.12/23.75)	TSSIQNMEGFVKTLDtKFQIP..KL
 1146- 1159 (20.81/ 8.44)	SASSGN......DLD...KIK..EL
 1166- 1189 (32.99/18.06)	TTPLQNMSQSPTGIN.DFSLPfnKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.91|      13|      18|    1199|    1213|      10
---------------------------------------------------------------------------
 1199- 1213 (20.73/19.11)	AML....PNVMQKmfAGHD
 1215- 1231 (19.18/ 9.62)	AMLlrrsPNLEHQ..ASND
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24889 with Med1 domain of Kingdom Metazoa
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