<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24878

Description CRSP complex subunit 2
SequenceMERKIEIYNFSASTRQLFIRLLALVKWANSASKVDKSAKIMAFLDKQSLLFIDTADMLSRMARETLVNARLPNFHIPAAVEILTSGTYSRLPSIIRERIVPPDPITPSEKRQTLQRLNQVIQHRLVTGNLMPQLRKFKIENGRVTFKVDHEFEVSLTVMGDGPNIPWRLLDIDILVEDKETGDGKALVHTLQVNYIHQLIQGRIVDSPDALAEVYNCLHYFSQSLQMEVLYTQTLRLMRDRLDDHIHVDEYIPGTKLTVSYWRELTNKDPKSELGYRLMIQTDQNDSAKQLAILHIPSIGNKEVDIADRAVRSDLLSMERLLVHTVYVRSLSRLADLKSELQLFLPDVDYSILGTPAMLMVPILNPCLRAEQIYITVDTHTGMLRCHVPKHLDCPIMAEMQHALNNDRSRLQHLFSELRYWITQRRCEKTLQHLPATTQERLPLVFPPGHAIEKVGPHKVYIQLYRHSNVILIVELKEKDSSPNEMTYTFYLVLVKPSSVEDSQSQDAEPTTSISQSGPGSVPPGGPPSVPGLSSSAAHPPNSSSATENDGMPKMYLKVQSLIEFDTFVATHGPGTYVDELAGSKRKLSALGEGPSKHQKVIYPAYFIPELAHVVAMCDEKLPFVALAKELTRRRIPHGGLQVEANATSLVLKLLTLPQPKAPLVPVSATAAAAGQQGGPDQKPPEPKLVSVPRIEKDVWNALLRRLLSVSVRAQVNKGNQTRLWTTELVFYGSPLTSAHHKEQGMRRAVYLQYDMSPVDAVDRIVDMILNDWSKIVYLYTLVHDFREQIDKYNLQNIVTIKSYSYTSLLLAYGPNKEVNVNIYWDIEAKEFKMVFTGGNNAINAHSMMRDQLQAHLNHNYDLAQIVHLLHETYQPLSSIAKLPIIPHLAILQSPKIPVLSFCIIPQSPTLLRISFQGVYCLEIRLRGSGLCSIRDGAYSRFDRSHVVEEFTPTQGLKGFLSKYVDETAVYRRRSQSEDDNPPSPITMEDPHGGPASVGSTFLGGGSMRGPQSPRDPGLRFAAPLTPPSGSNPHTPASPHPQGMGGGGSQNHPNFNMTSPPAPHMPHPSPSGGLMPSSPLNPQPSPMAHSPGPSNMPYMGGQSHTDGSPFTAAHSPAASNWPGSPGMPRPSPRPGQSPDHKTQTPHHNTSRVLPARSWAGAIPTLLTHEALDTLCRATAHPQKEIPGPELSPLERFLGSVFMRRQLQRIIHQEENQLQAITSNEPGVVLFKADNLQYQVFLNPNHMQSLHMKVSQAPQMAPTMDGKPPYQWSPEDLQALEQFFDQRVAAPPYRPAVVTSFTRMLNLSAQVMKDMIQIMRLDLMPEMGQGNKWNVQFILRMPPSATPIVPVGTTTILSHRQKILFFIQITRVPYLPNMEWKDCVTMLLPMVYDMTVNHTQLAERREQNVPQLTSAVSAHLRRFAECTVLPPGECSLFPAVRDLLMNLTLPNEQPPPGQMPNQIGPMGAMPPGGPGQIAPSPVGSSPNPMMHSPMQMGGAGGQQYAGMAGAGPGGPGQGGAGGPN
Length1523
PositionTail
OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Culicinae> Culicini> Culex> Culex.
Aromaticity0.07
Grand average of hydropathy-0.313
Instability index56.16
Isoelectric point8.31
Molecular weight168941.18
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24878
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     457.72|      73|      73|     991|    1063|       1
---------------------------------------------------------------------------
  518-  553 (52.43/21.12)	G...P...GSVPPGG.....P..PSVPGLSSSAAHPPNSSSAT.ENDGMP..............................
  640-  687 (46.95/17.88)	GlqvEANATSLVLKLLTLPQPKAPLVPVSATAAAAGQQGGPD..QKP..PEP............................
  994- 1068 (139.53/72.58)	G...PASVGSTFLGGGSMRGPQSPRDPGLRFAAPLTPPSGSNP.HTPASPHPQGMGGGGSQNHPNFNMTSPPAP.hmPHP
 1069- 1114 (75.56/34.78)	S...PS..G..................GLMPSSPLNPQPSPMA.H...SPGPSNMPYMGGQSHTD......GSPftaAH.
 1115- 1146 (44.74/16.58)	S...PAA..SNWPGSPGMPRP.SPR.PG............QSPdHKTQTPH.............................
 1463- 1512 (98.51/48.34)	G...P..MGAMPPGGPGQIAP...........SPVGSSPNPMM.H...SP..MQMGGAGGQQYAGMAGAGP........G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.36|      39|      78|     332|     370|       2
---------------------------------------------------------------------------
  332-  370 (67.74/42.89)	SRLADLKSELQLFLPD..VDYSILGTPAMLM..VPILNPCLRA
  409-  451 (62.62/39.02)	SRLQHLFSELRYWITQrrCEKTLQHLPATTQerLPLVFPPGHA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.00|      61|      75|      54|     115|       5
---------------------------------------------------------------------------
   54-  115 (98.41/68.31)	TADMLSRMARETLVNARLpNFHIPAAVEI.LT.SGTYSRLP.SIIRERIVPPDPITPSEKR..QTLQ
  127-  192 (86.59/54.62)	TGNLMPQLRKFKIENGRV.TFKVDHEFEVsLTvMGDGPNIPwRLLDIDILVEDKETGDGKAlvHTLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.80|      32|     384|     564|     595|      10
---------------------------------------------------------------------------
  564-  595 (54.09/38.50)	EFDTFVATHG.PGTYVDELAGSKRKLSALGEGP
  918-  938 (25.56/13.71)	............GVYCLEIRLRGSGLCSIRDGA
  950-  982 (49.15/34.21)	EFTPTQGLKGfLSKYVDETAVYRRRSQSEDDNP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24878 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVYRRRSQSEDDNPPSPITMEDPHGGPASVGSTFLGGGSMRGPQSPRDPGLRFAAPLTPPSGSNPHTPASPHPQGMGGGGSQNHPNFNMTSPPAPHMPHPSPSGGLMPSSPLNPQPSPMAHSPGPSNMPYMGGQSHTDGSPFTAAHSPAASNWPGSPGMPRPSPRPGQSPDHKTQTPHHNTSRVLPARSWA
2) EDSQSQDAEPTTSISQSGPGSVPPGGPPSVPGLSSSAAHPPNSSSATENDG
3) MNLTLPNEQPPPGQMPNQIGPMGAMPPGGPGQIAPSPVGSSPNPMMHSPMQMGGAGGQQYAGMAGAGPGGPGQGGAGGPN
969
501
1444
1159
551
1523










Molecular Recognition Features






MoRF SequenceStartStop




1) AGMAGA
1504
1509