<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24871
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MRIISVLLVDRETGSRRNDPPRKPTFPRKVPRLLPSNFGTAKAQKEPPRNNGVPRRKYRKHSTTRNRFRVWWDHNRRIHTPQTHNKSVRRKKTVLQLVELLVSKDKEMKSTLQLAADQAGIERKLDGLRDQVRDQDKEINQLQKQLKEAEYILATSIFQARQKLTSFAKATKRPVLSDELIKFAHRKIASNAICAPLTWQQGDQRQPYPTDRDAAGLPLQFRHQRAPECGQPEQSRRN |
Length | 238 |
Position | Middle |
Organism | Culex quinquefasciatus (Southern house mosquito) (Culex pungens) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae>
Culicinae> Culicini> Culex> Culex.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -1.057 |
Instability index | 53.30 |
Isoelectric point | 10.95 |
Molecular weight | 27759.49 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP24871
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 63.12| 16| 125| 41| 81| 1
---------------------------------------------------------------------------
17- 32 (31.99/11.66) RNDPPRKPTFPRKVPR
44- 59 (31.13/38.03) QKEPPRNNGVPRRKYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 53.87| 15| 21| 191| 207| 2
---------------------------------------------------------------------------
191- 207 (25.70/17.73) NAICAPLTWQQgdQRQP
213- 227 (28.17/13.38) DAAGLPLQFRH..QRAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 27.81| 9| 28| 104| 113| 3
---------------------------------------------------------------------------
104- 113 (11.61/14.76) KDKEMkSTLQ
135- 143 (16.20/13.02) QDKEI.NQLQ
---------------------------------------------------------------------------
|