<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24867
Description |
Mediator of RNA polymerase II transcription subunit 15 |
Sequence | MTEDNSWKTSSFRQSVVNKINEAIQQSGMTSSKNGLEMENHVFTKARNKDEYLGYVARLILHVREMNSKNKNQQNAAGANQDGGGNPGQQGGMPDPINALQTLAQQGTRPPMMGGGQMGGPGMGPGQIGAGNASNLLQTLNRPQMPMTGGMANMPNRVGGGQMMPGQQGPGGMQMGMGGMSGGKIVGMGNQGQMAMMQQGGPQQGVPGGPNQMNAMGGMGGMQVNPGGQMNQNALNQQLNPGGMNPGAGQMVGNNPMNPGQMGMGPNQMIRQQMPPGMNPNQQMAMAGGQMNQMNQGVGGPGGNLGQVQQVAGQQQVQGGMPPNLQQPGGPGGPNVGGGQMNAGGMGPGGAMPGNQMAGQGNFVPGMVRKPQDMMSGGQVFPGGAVRSVTPNQFLRQSPSPSVPSPVGPGSLGPQSHPGQMIPSPALIPSPSPQMGSVPPRNIGQSPGSNLNTPGQPGGAAPSPLNPQEEQLYREKYRSLTKYIEPLKRMIAKMENDDHDKIGKMKRLLEILCNPTCRIPLETLYKCEAALTSQLGSIRETPLNNPLVEAVSANLQSSLGNHTLQRTFRPCLEALFGPDIKNLPTPAKQPRLAVDDPQSSSLSGGQEIPHILQGEIARLDQKFKVSLDQCAIGGTKTIKLICWLDDKHLPCVPPIAVTIPDEYPFTSPTCSLIEQEYNATPFLVQVQQSFLARICKLPEMFSLSHLLDTWEMSVRQACAPNPSLVAPSATSVLLGM |
Length | 736 |
Position | Tail |
Organism | Culex quinquefasciatus (Southern house mosquito) (Culex pungens) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae>
Culicinae> Culicini> Culex> Culex.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.499 |
Instability index | 55.83 |
Isoelectric point | 8.91 |
Molecular weight | 77360.71 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364148
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP24867
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 188.56| 33| 33| 299| 331| 1
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182- 215 (42.07/ 7.61) .GGKivgMG....NQGQMAMMQQGGPQQGVP.GG.PNQMNA
216- 250 (46.49/ 9.28) MGGM...GGmqvnPG...GQMNQNALNQQLNpGGMNPGAGQ
256- 283 (46.12/ 9.14) PMNP.gqMG....MGPN....QMI..RQQMP.PGMNPN.QQ
299- 327 (53.89/12.09) .......GG....PGGNLGQVQQVAGQQQVQ.GGMPPNLQQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
5| 219.81| 31| 31| 83| 113| 2
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83- 112 (58.27/17.68) .GGGN..PGQQ...GGM.PDPINA......L..QTLAQ..QGT......RP..P..M
113- 147 (46.24/12.21) MGGGQ..MGGP...GMG.PGQIGAgnasnlL..QTL......N......RPqmP..M
336- 374 (37.36/ 8.17) VGGGQ..MNAG...GMG.PG..GA......MpgNQMAG..QGNfvpgmvRK..PqdM
375- 406 (34.81/ 7.01) MSGGQvfPG......GA.VRSVTP......N..QFLRQspSPS......VP..S..P
407- 441 (43.13/10.80) VGPGS..LGPQshpGQMiPSPALI......P..SPSPQ..MGS......VP..P..R
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