<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24854

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSDWDTGWEHKAISRPLILCQLQIQYSYSLPGSPSFLIVHPILQATPFLDLTPSIPLPSAYFLANYNGPVSGIAKQFRESLRGLGIGDWEGHCVPSKDPHRPAHGPSVNNFGQTPSFIIGWIKVENKQGEDKGITIIYPSSLCLSYMPSSCPRPLDYIPELPTPLQPSPQVPPATPSIFSSLSPSDTGELSSFYAARLPIPVSPTCDSLRSFRTLTLSKSKDIRQAATEIGSYVDAVARDRERERERLRREREVGTSSSPKISRSVTSTSTSVSMPVEMDITNPAAPTVLPTNPSQHSAYPPAQSFYPSPPQINPTIVPGSDSKTSPVARTEALPLTETSSSCTPVEAQFNESAPTSAVSGTYDPFGNMDGAWSQSGASYLDADIDMDFGMDLDMGFNMNMNSMSGGGRSGAYNDRDGMDFEDAFTDDDFSFFDRPSRPSAVALPSAFSSTNFSQSHHSPDNAGPSLPVPASQMLLGNSPFSAMHGDVSKLPQYTPASHSSVWTPGVSTEESIHRQHDHPDFKLPELLPSSSAQTPESHSAPPTPNVILEFDPVIRRPTTSTGYSSPFEPIPFAQHHRAADHKYAQGKFSLSSSNEDDRAEFLFNYLPSSPNGSNGWRLRYDAVTDPRIGVVRKLIGVKRKTPFGHTERRSGKLSLWIRSHEDWELPNDEEGVDDQSELESEDGDVGDNESPLMSRPVTPPPAYLPLGPSLLHTQFHHSELLPLSVPLRPPGAAVAPTNLTASAPLPSVPTPVSPAVTMGAASEKSKSLEAAAFAIAAEVVENPLWAEAWRANTGPKDASDVWAADIRAVAELLEDAPNLEGLIDVASLFGLEISSARPHTFHPLEAPMITVGKGEAVIHILPPALHFWEKLGLGPKGGPKDILGYVLFEDGGEQRERQVESWLERTVAAYRGKHFGTLNPGPDCFVNGLVTLRYDSTFRKSLASFIGNLDLSERPVVVFIVLPATIMTLVSPILRQVLSFLSRTHFHTRKATLQQSDIYRYTMLHVAYHVTACGKWILAACTDERGEAYDLNVWLTQSPSEQEGETEISDEVYMVRKVWDFFMQFARRADTEWRLVISKLGTMKESEMHAWTEHLTTALELSIPPLHASIISVEPDAPWSFVTSRVNPSSPSRRTAQHRPSSSTKHQVILTDVSATTYAIFPTSQMPMSLAASYKNLGVSLSFVPEPPSPANPTSPAASPLFVNSIPASQYHNFNSDCVATLRTDQEPHRLAFIPRSTSTLIRIPNTPSQTSVSMLHIYLLHTLQSPHSSSVSLPDESKLHVAITRNFHDLAVLSKIRWNLDANPLLPFHLAAVDAMRISLDRDWDRLDGVVDS
Length1335
PositionKinase
OrganismLaccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Tricholomataceae> Laccaria.
Aromaticity0.08
Grand average of hydropathy-0.320
Instability index58.16
Isoelectric point5.51
Molecular weight146218.53
Publications
PubMed=18322534

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24854
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     358.53|      76|      78|      34|     110|       1
---------------------------------------------------------------------------
   34-   91 (86.21/32.63)	.......................PSFLIVHPILQAT..P.FLD.LTPS.IPLPSAYFLANYNGPVSGIAKQFRESLRGLGIGDWEG
   92-  168 (117.78/48.64)	HCVPSKDPHRPAHGPSVNnfgqtPSFIIGWIKVENK..Q.GED.KGIT.IIYPSSLCLS.YM.P.SSCPRPL.DYIPELPTPLQPS
  169-  218 (62.23/21.62)	PQVPPATPS..............................iFSS.LSPSdTGELSSFYAARLPIPVSPTCDSLR.SFRTLTLS....
  287-  356 (92.31/35.66)	PTVLPTNPSQHSAYPPAQ......SFYPSPPQINPTivP.GSDsKTSP.VARTEALPLTETSSSCTPVEAQFNESAPT........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     157.91|      31|      39|     495|     525|       2
---------------------------------------------------------------------------
  436-  465 (36.77/13.50)	.PSRPSAVALPSAfsSTN..FS..QSHHSPDN.AGP
  469-  492 (32.37/11.01)	VPASQMLL...GN..SPF..SAMH.....GDVsKLP
  495-  525 (63.04/28.42)	TPASHSSVWTPGV..STE..ESIHRQHDHPDF.KLP
  535-  558 (25.73/ 7.24)	TPESHSAPPTPNV..ILEfdPVIRRP..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.45|      10|      78|     898|     907|       3
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  898-  907 (20.07/12.59)	RQVESWLERT
  976-  985 (18.38/10.88)	RQVLSFLSRT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.79|      30|      78|     790|     819|       4
---------------------------------------------------------------------------
  790-  819 (52.60/33.42)	W.RANT.GPKDASDVWAADIRAVAELLEDAPN
  837-  865 (37.33/21.31)	A.RPHTfHPLEAPMITVGKGEAVIHILPPA..
  869-  894 (38.87/22.53)	WeKLGL.GPKGGPK....DILGYV.LFEDGGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.99|      23|      49|     360|     382|       5
---------------------------------------------------------------------------
  360-  382 (44.36/32.12)	SGTYDPFG.NMD..GAW.....SQSGASYLD
  383-  408 (19.20/ 8.81)	ADIDMDFGmDLD..MGFnmnmnSMSGGG...
  410-  434 (36.43/24.77)	SGAYNDRD.GMDfeDAF.....TDDDFSFFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.64|      30|      54|    1129|    1162|       6
---------------------------------------------------------------------------
 1129- 1162 (46.57/30.91)	PSSPSrrtaQHRPSSSTKHQVILTDVSATTYAIF
 1186- 1215 (56.07/28.88)	PEPPS....PANPTSPAASPLFVNSIPASQYHNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.00|      16|      50|     692|     708|       7
---------------------------------------------------------------------------
  692-  708 (27.79/15.37)	PLMSRPVTPPPAyLPLG
  745-  760 (31.21/13.00)	PLPSVPTPVSPA.VTMG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24854 with Med13 domain of Kingdom Fungi
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