<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24849

Description Predicted protein
SequenceMYYYRGRRDGLHRAVSSKYTILGFISSGTYGRVYKAQSLEEDQKIHAIKKFKPDKEGDVITYTGISQSAIREIALNKEIDHENVVALKEVILEDKSIYMVFEYAEHDFLQVIHHHSQTLRQTISTPVLKSLVYQLFNGLLYLHSCHILHRDLKPANILITSSGVVKIGDLGLARLIYQPLQPLFAGDKVVVTIWYRAPELLLGAKHYNKAIDCWAVGCVMAELASLKPIFKGEEAKLDSKKNVPFQRDQLLKIFEVVGTPDEQDWPGLADMPEYQSMKRLDHFSNRLSDWCQSRIRSQLGYDLLRQLFAYDPDNRLTAREALQHKWFQEDPKPTWNAFQTNTSHHGGHGHMGGPFGQSHSKPGSSASFASLSGGGHYGGHASGGAGNGTHGPSRKKARLG
Length400
PositionKinase
OrganismLaccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Tricholomataceae> Laccaria.
Aromaticity0.10
Grand average of hydropathy-0.422
Instability index42.45
Isoelectric point8.98
Molecular weight44939.58
Publications
PubMed=18322534

Function

Annotated function 
GO - Cellular Component
euchromatin	GO:0000791	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IEA:EnsemblFungi

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24849
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.62|      28|      30|     332|     359|       1
---------------------------------------------------------------------------
  332-  359 (60.89/34.83)	KPTWNA.FQ..TNTSHHGGH..GHMG.GPFGQSH
  361-  394 (38.73/19.60)	KPGSSAsFAslSGGGHYGGHasGGAGnGTHGPSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.02|      11|      45|     128|     138|       2
---------------------------------------------------------------------------
  128-  138 (20.96/14.64)	LKSLVYQ....LFNG
  172-  186 (15.06/ 8.61)	LARLIYQplqpLFAG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24849 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EDPKPTWNAFQTNTSHHGGHGHMGGPFGQSHSKPGSSASFASLSGGGHYGGHASGGAGNGTHGPSRKKARLG
329
400










Molecular Recognition Features






MoRF SequenceStartStop




1) GTHGPSRKKARLG
2) MYYYRGRR
388
1
400
8