<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24843
Description |
Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MDVNDLHPPDDYSHRFFIWHEWIQANGPLTSENVFDYFATSMFYDKQSNNQVLRMQTIHTGMPIVNEAEELRRFVGIEFAVVHAEPPSFFVIQKRERLSPDEVRPLAAYFVTNNRIYQSPDLYTVLSNRLLTSVSALQSSLDILRKHRPDYTPRSGFVWPIVDSSTAEDGAKKRDAETGDASSVISQARPTEEPKKQQNNMLLVNAMRATALHSKMSFTTTSAAHVENATTETPVAAPMRSSATPAPAPQDTSTKGDSTAAIQDATRAPPGAGKKKKKRSWINT |
Length | 284 |
Position | Head |
Organism | Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes>
Agaricomycetidae> Agaricales> Tricholomataceae> Laccaria.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.564 |
Instability index | 55.40 |
Isoelectric point | 7.12 |
Molecular weight | 31709.19 |
Publications | PubMed=18322534
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP24843
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 226.63| 70| 77| 136| 205| 1
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47- 119 (75.03/48.91) ..QSNNQVLRM...Q....TIHTGM..PI..........VN..EAEElrrfvG.IEFAVVHAEPPSFFVIQKRerlsPDEvRPLAAyfvTNNRIYQS
136- 205 (119.96/82.79) ALQSSLDILRK...HRPDYTPRSGFVWPI..........VDSSTAED.....G.AKKRDAETGDASSVISQAR....PTE.EPKKQ...QNNMLLVN
211- 265 (31.63/16.19) ALHSKMSFTTTsaaHVENATTETPVAAPMrssatpapapQDTSTKGD.....StAAIQDA.....................................
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