<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24841

Description AT-rich binding protein
SequenceMGFPRILSKNHKIYTKLGEFCLSGDSFWIVCHTCQEELQTQDAFWKHIQDEHNFLHGVAKQEHNRSSSSSYCLADVESASAVTSNTTSVQTAGNVTTVAVPVALYKYTEDEQRDVAAAVELHEAQHQQQQQQQQHQQQQQQQQHQQQQQHQHHQHQQQQQHLHQQQQQQQQQQRDAAKELAELHAVAAAAAAAGGGGGDSSAHSSSIGGGIDIKVELTPEMQVAAAAAAAASSNTTIYHLSQVVPVSAPAPPPPPPTAAAASSFLSGGAGSATAATIVGVSTTATTTAAAAAAVTTVPQQSQLGSGNNAGAVMQQLGLPLIAVAQELAPKDSNSTTASASSAVSSDDGERWYVCDYGTCGIKFKYKSRMELHRVVHSKERRFNCDMCSASFKQSCNLSTHRKKKHSLRGIKSDLLPQRF
Length419
PositionKinase
OrganismDrosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Hawaiian Drosophila.
Aromaticity0.05
Grand average of hydropathy-0.537
Instability index55.00
Isoelectric point6.75
Molecular weight44984.16
Publications
PubMed=17994087

Function

Annotated function May be a transcription factor for genes having (A+T) stretches in their promoter and/or enhancer regions. Binds to AT rich DNA (By similarity). 
ECO:0000250	UniProtKB:Q86P48
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell
GO - Biological Function
DNA binding	GO:0003677	IEA:UniProtKB-KW
metal ion binding	GO:0046872	IEA:UniProtKB-KW
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	ISS:UniProtKB

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP24841
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.99|      16|      16|     125|     140|       1
---------------------------------------------------------------------------
  125-  140 (35.79/12.36)	QHQQQQQQQQHQQQQQ
  143-  158 (35.73/12.33)	QHQQQQQHQHHQHQQQ
  159-  174 (31.48/10.19)	QQHLHQQQQQQQQQQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     147.08|      34|      34|     186|     219|       2
---------------------------------------------------------------------------
  179-  210 (36.37/17.02)	.....ELAElhaV...A...AAAAAAGGGGGDSSAHSSSIGGG
  211-  245 (42.95/21.39)	IDIKVELTPemqV...A...AAAAAA.ASSNTTIYHLSQV.VP
  246-  279 (37.61/17.84)	VSAPAPPPP........pptAAAASSFLSGGAGSATAATIVG.
  280-  311 (30.16/12.89)	....VSTTA....tttA...AAAAAVTTVPQQSQLGSGNNAGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.81|      23|      27|     349|     373|       3
---------------------------------------------------------------------------
  349-  373 (42.34/29.02)	ERWYVCDYgtCGIKFKYKSRMELHR
  379-  401 (45.46/25.25)	ERRFNCDM..CSASFKQSCNLSTHR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24841 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RDVAAAVELHEAQHQQQQQQQQHQQQQQQQQHQQQQQHQHHQHQQQQQHLHQQQQQQQQQQRDAAKELAELHAVAAAAAAAGGGGGDSSAHSSSIGGGIDIKVE
113
216










Molecular Recognition Features






MoRF SequenceStartStop




NANANA