<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24840

Description Isoform d of Ankyrin repeat and KH domain-containing protein mask-1
SequenceMAHLNMFNHLIPLEMDMDGADEEKRQRVFSSFYHFGARLYDCLHTIAIEIEDDDCEHFPTKAISTVLKILNFEHFLSSDKCRFPPVSNLLDIIESRQMDDCQILFKISDLLEDHKSEKPERFGPYNPLDPKKVPIKNAVDALTSVSSMAYSFLATTFAEELMKAAIRDIYVFDEDSLEDNDETQLSDENGVFDSTPSNNEKKDSIINFRQLPSIDSQIVQQNAMLLLAARVGIEQFVEYSHEIGVMQFRGDKLSKITPLMEAAASSSETIVRRLLELGADPNVASIPNCNTALIYAASTDGRDVVREILMTEGPKKPDVYLINNHYHDAMMEVALVGGTDTLKEFLEMGYRPRFLNLRQQERDSALTLSAQKGHIKIVTAIMDYYEKNPPQTEEEKQELCLERYSALMEAAMEGHIDVCKLMLSRGTPADLCTEVTIEPSPLIVASAGGYPEVVEVLLAAGAKIEELSNKKNTPLMEACAGDQGDQAGVVKLLLSKHAEVDVSNPDTGDTPLSLAARNGYIAIMKMLIEKGGDLTAGKTSPIVEAARNGHLECIQFILAHCKTIPQDQLSRALVSAADFGSLLIVEEVIRAGADLNFEQDERTALMKAAKGDHFEVVQLLLSKGASVNFKSSKNDATALSLACSEGNMEIAEFLIRNGADPMLKMDDGVNCFMEVARHGSIDLMSLLVEFTKGNMPMDKDPPKLGITRCSSKNGKKRRKGMPSGQDMLSMFNGMYPKRKGSKQMGLHEMPFSTQEIDMLTHLLKMQQQMVAYETHKSTETETAEIKKVLRAIESVYGFTSEGKINFPPPPNRQDMDKLYNGELVPNIKLWAELVSHGWLEMERKIGRPIELSSFQQCNEGHSTNAAAAVSAVAAAATGMDSQTYLASVFAKMNNGEEMPRVPATVGSLNAASAAMTGISFHSDDAMRLFGGASFATKLLSDNKKPCNHQQYASIHHIQEGAFRAALIKMSSMFRERNGCAISVRDMESNFPIEHQEERFGPSKPIPSGPKKTSLTAPNPADTSDVTTKQPGAMKKDGLEAKKIYPGIIKLAAEMEKLFRANPTESNRDLALTTAYIASALPDHFCSELQLESGDRILKKLLSGLTEKQKNTVISRMRSVVNKESGSSLLRRSVDNLTDKRIKEDYLKLFRDSTDCAFYDKCVQEKNHLLKAIEIQKKGKTSSGTLISTSSKSLMAKSVQSQQQQGQLRRTHSEGDGAERAKSRSNAIDKATETTLETPLTIACANGHKDIVELLLKEGANIEHRDKKGFSPLIIAATAGHSSVVEVLLKNHAAIEAQSDRTKDTALSLACSGGRKDVVELLLAHGANKEHRNVSDYTPLSLASSGGYIEIVNMLLTAGSEINSRTGSKLGISPLMLASMNGHREATRVLLEKGSDINAQIETNRNTALTLASFQGRTEVVKLLLAYNANVEHRAKTGLTPLMECASGGYVDVGNLLIAAGADTNASPVQQTKDTALTISAEKGHEKFVRMLLNGDAAVDVRNKKGCTALWLACNGGYLSTAQALLEKGADPDMFDNRKISPMMAAFRKGHVEIVKYMVNSAKQFPNEQDLIRAQQTAETDDIKKKCGECIDIIRSAKKAQAESAELAAQKLLELIDEEKVQKEVKKQKQKDKKIKKKEEKKIKKQEAEPEPEPEPEPEPVPEPEPVVISEPVPEPVPIVVEEPPKEPPKPRRNRRKTNPDGVPKGPKVVVEPKASIAEEPSEMPYEPIVVTIPPPAKIHAPMVSPGSYSESEEWCKAGKEGKKVKSSKKSGYGAPSSAGSSQAKESSTTSSVISDQTPPYEIDTRNESSWKLTIPAYAASRVIGKGGSNVNAVREATGAIIEINKIQESNKQAERTVLAKGTPEMVRYAMNIINYMIYDADVLVTDAIRTVLRGNLSVASSFSSEGTSKSAVDSTYAPSSIPKSLSSASIARQSASPIPQQSSQRSAKSHHHQKDSGGGNVWHQRMAAREEKVEPLMETKRISQSPKQAPQIPSTQQQSKLQSRQDQASETLVRVAPAENFVAPVPASSIAAPSRPNQNVLDRVIAPSLRREPTTTPLIQPVHPVQSVQSVQHMQQQQLARPEQKLAQPCLPDPIGQRYSQPISRPQSSVQVSQSSFSKAPGTRPSTDFSRAPGPPQQQQTQNNMTTARNELFDEQLAFGQFKPTGMNSVATVIPAKPSVNNQNDDKNGNSDDFDFSKMRMFDEGKVGNIWGKSDEDSAWGGLFSQFLPQLGANSSLNNSNSKNDSSNEWGQNEFISQLLINSSLPNATSSPQGASTISSAPVQQPSTSSVTTGLSSLELKGWMPASFAPSARDPNRSQPPLFARSQSNSVANSTSTNIQQQQQQQIQHLQQQQALQQQQQRIQQFQQQYQQHQSQSSQQPSDLMSSKFSMLQSQQQQQQLYNQMQSLGQDGQGSNLYNHLAAQLLTHQESSTGAPGPTSSQLANSYYPSPSYTDASVLGQISMPSLSQRGIKQFDGFNNDSDGVIAAILEQQQQQKKQGLAQQSFMHNSQQPQPFGAPSNASANQSRLGMIQPRPQPPPFVAPQAPPGFSSLGNASSTTNPSRTSMQQMYQQYGQSSQQQPYGQMPQAMDWNRLGQQQQSASGQQNHQSSSSNKWSSNW
Length1427
PositionKinase
OrganismCaenorhabditis elegans
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.05
Grand average of hydropathy-0.544
Instability index53.03
Isoelectric point6.36
Molecular weight287074.70
Publications
PubMed=9851916

Function

Annotated function 
GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell

GO - Biological Function
RNA binding	GO:0003723	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24840
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            17|     510.80|      29|      31|    1238|    1266|       1
---------------------------------------------------------------------------
  258-  282 (26.81/11.33)	...........PLMEAAASSSET...IVRRLLELGADPN
  441-  465 (29.93/13.49)	...........PLIVASAGGYPE...VVEVLLAAGAKIE
  466-  501 (28.80/12.71)	ELSN...kkntPLMEACAGDQGDqagVVKLLLSKHAEVD
  502-  535 (32.48/15.26)	VSNP..dtgdtPLSLAARNGYIA...IMKMLIEKGGDLT
  536-  565 (22.58/ 8.40)	.AGK.....tsPIVEAARNGHLE...CIQFILAHCKTIP
  566-  596 (19.71/ 6.41)	.QDQ....lsrALVSAADFGSLL...IVEEVIRAGADLN
  598-  628 (35.50/17.35)	EQDE.....rtALMKAAKGDHFE...VVQLLLSKGASVN
  629-  661 (29.85/13.44)	FKSS..kndatALSLACSEGNME...IAEFLIRNGAD.P
 1238- 1262 (34.90/16.93)	...........PLTIACANGHKD...IVELLLKEGANIE
 1263- 1295 (30.99/14.22)	HRDK...kgfsPLIIAATAGHSS...VVEVLLKNHAAIE
 1296- 1328 (35.42/17.30)	AQSD..rtkdtALSLACSGGRKD...VVELLLAHGAN.K
 1329- 1362 (34.85/16.90)	EHRN..vsdytPLSLASSGGYIE...IVNMLLTAGSEIN
 1363- 1397 (32.41/15.21)	SRTG.sklgisPLMLASMNGHRE...ATRVLLEKGSDIN
 1398- 1431 (27.67/11.92)	AQIE..tnrntALTLASFQGRTE...VVKLLLAYNANVE
 1432- 1464 (35.83/17.58)	HRAK...tgltPLMECASGGYVD...VGNLLIAAGADTN
 1465- 1499 (19.23/ 6.08)	.ASPvqqtkdtALTISAEKGHEK...FVRMLLNGDAAVD
 1500- 1532 (33.84/16.20)	VRNK...kgctALWLACNGGYLS...TAQALLEKGADPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     279.20|      34|      34|    2342|    2375|       2
---------------------------------------------------------------------------
 2066- 2107 (34.67/12.61)	..QSV.QSVQHMQQQ...Q........LARPEQKLAQPclpdpiGQRYSQPisrpQ
 2113- 2145 (37.30/14.16)	S.QSSfSKAPGTRPS...T..D.....FSRAPGPPQQ.......QQTQNNM.....
 2341- 2374 (63.34/29.58)	Q.QQQ.QQIQHLQQQ...Q..A.....LQQQQQRIQQF......QQQYQQH....Q
 2375- 2406 (46.88/19.83)	S.QSS.QQPSDLMSS...KfsM.....LQSQQQ...Q.......QQLYNQM....Q
 2407- 2442 (26.72/ 7.90)	SlGQD.GQGSNLYNHlaaQ..L.....LTHQESSTGAP......GPTSSQ......
 2493- 2516 (25.82/ 7.37)	..QQQ.QKKQGLAQQ...S..F.....MHNSQQ.PQPF..................
 2575- 2609 (44.47/18.41)	G.QSS.QQQPYGQMP...Q..AmdwnrLGQQQQSASG.......Q...QNH....Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.82|      34|      34|    1650|    1683|       3
---------------------------------------------------------------------------
 1650- 1676 (43.33/20.46)	.........EP....EPEP.......EPEPVP.......EPEPVVISEPVPEPV
 1677- 1725 (46.69/22.70)	PIVVEEPpkEP.....PKPrrnrrktNPDGVPkgpkvvvEPKASIAEEPSEMPY
 1727- 1752 (26.80/ 9.42)	PIVVTIP..PPakihAPMV.......SPGSYS.......ESE............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.73|      26|      39|     352|     377|       4
---------------------------------------------------------------------------
  352-  377 (44.63/33.23)	PRFLNLRQQ...ERDSALTLSAQKGHIKI
  390-  418 (40.56/29.31)	PQTEEEKQElclERYSALMEAAMEGHIDV
 1540- 1553 (16.53/ 6.22)	...............SPMMAAFRKGHVEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.56|      36|      39|    2256|    2291|       5
---------------------------------------------------------------------------
 1910- 1945 (50.29/23.44)	SA...VDSTYAPSSIPKSLSSASI.ARQ.SASPIpQQSSQR
 2256- 2289 (50.85/23.79)	.....ISQLLINSSLPNATSSPQG.ASTISSAPV.QQPSTS
 2290- 2328 (49.42/22.89)	SVttgLSSLELKGWMP.ASFAPSArDPNRSQPPL.FARSQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.67|      19|      39|      73|      91|       6
---------------------------------------------------------------------------
   73-   91 (37.77/19.63)	EHFLSSDK.CRFPPVSNLLD
  113-  129 (27.06/11.88)	DH..KSEKpERFGPY.NPLD
  798-  814 (28.83/13.16)	..FTSEGK.INFPPPPNRQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.98|      21|      63|    2159|    2188|       7
---------------------------------------------------------------------------
 2165- 2201 (23.16/26.22)	TGMNSVAtvipakpSVNNQNDDkngnsddfdFSKMRM
 2202- 2229 (28.82/12.49)	FDEGKVG.......NIWGKSDE..dsawgglFSQFLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     111.87|      29|      34|     851|     879|       9
---------------------------------------------------------------------------
  851-  872 (29.77/14.94)	............LSS.FQQ.CN...........EGHS.TNAAAAVSAV
  873-  908 (29.57/14.78)	AAAATGMdsqtyLASvFAK.MN...........NGEEmPRVPATVGSL
  909-  931 (23.78/10.27)	NAASAAM....tGIS.F..................HS.DDAMRLFGG.
  932-  972 (28.75/14.14)	ASFATKL.....LSD.NKKpCNhqqyasihhiqEGAF.RAALIKMSSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.37|      40|      63|    1758|    1798|      10
---------------------------------------------------------------------------
 1758- 1798 (59.45/39.97)	GKEGKKVKSSKKSGyGAPSSAGSSQAKESSTTSSVISDQTP
 1824- 1863 (63.91/38.13)	GKGGSNVNAVREAT.GAIIEINKIQESNKQAERTVLAKGTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      92.83|      19|     470|    2046|    2064|      11
---------------------------------------------------------------------------
 1981- 1997 (19.03/ 6.07)	..RI..SQSPKQAPQIPSTQQ
 1998- 2017 (19.89/ 6.72)	QSKLqsRQDQASETLVR.VAP
 2023- 2036 (20.75/ 7.37)	APV......PASS.IAAPSRP
 2046- 2064 (33.15/16.78)	APSL..RREPTTTPLIQPVHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.29|      18|      34|    1091|    1108|      12
---------------------------------------------------------------------------
 1091- 1108 (29.47/21.62)	ESGDRILKKLLSGLTEKQ
 1123- 1140 (29.82/21.98)	ESGSSLLRRSVDNLTDKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.97|      24|      39|     286|     309|      13
---------------------------------------------------------------------------
  286-  309 (41.42/27.34)	IPN.CNTALIYAASTDGRDVVREIL
  322-  346 (37.55/24.08)	INNhYHDAMMEVALVGGTDTLKEFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.85|      13|      39|    2525|    2537|      14
---------------------------------------------------------------------------
 2525- 2537 (25.22/16.41)	NQSRLGMIQPRPQ
 2561- 2573 (25.63/16.82)	NPSRTSMQQMYQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      63.42|      21|      39|     686|     706|      15
---------------------------------------------------------------------------
  686-  700 (20.46/ 8.10)	......LLVEF...........TKGNMPMDKD
  701-  726 (19.04/ 7.00)	PPKLGI.....trcsskngkkrRKG.MPSGQD
  741-  758 (23.92/10.79)	SKQMGLHEMPF...........STQEIDM...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.77|      12|      21|    1617|    1628|      17
---------------------------------------------------------------------------
 1617- 1628 (18.90/10.39)	EEKVQKEVKKQK
 1635- 1646 (18.87/10.36)	KKKEEKKIKKQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.11|      22|     167|    1028|    1073|      18
---------------------------------------------------------------------------
 1006- 1027 (41.22/31.22)	PSGPKKTSLTA....P...............NPADTS.D..VTT
 1030- 1073 (16.89/59.18)	PGAMKKDGLEAkkiyPgiiklaaemeklfraNPTESNrDlaLTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.25|      13|      33|       9|      21|      20
---------------------------------------------------------------------------
    9-   21 (23.96/16.79)	HLIPLEMDMDGAD
   44-   56 (23.29/16.07)	HTIAIEIEDDDCE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24840 with Med12 domain of Kingdom Metazoa
Unable to open file!