<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24808

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMALHLIQDVEAAGAELFTLLVSTTVRDSWPEIESDAPHLPSVLHAIHILLTRFNAVSSPSPRAKATLQSLNALKNGLTTPLNDDLFGEQQPAASVPSLWASRAFFSYAVSLQLVWRQVESSGGRRPVLPPPVFPEPETILLVHGLCAPNLNWYQKCLEALGILKTRLHYSNEPPNDICCAYLMEIFVAITHAAIVQLKRHPTERHAQVWRHVIGGLLPPLALFLGGSVPASNNDVLNVQDTVSSFIAFYEPVNDWMHLDAQIMAPSHAATLPDLMQDSFAAWLPGHSKKTTSIELENLHQYASTSVQSFRQIVHTSLLHNPSACGNLIERAVKEPCLQLVLAMELNHLLSEWTEFMSAEFMHMHAICYLLQSGAPQNLDMLCLYMGQQLLPHTLVHVLSHMDQSMWSHPDDALNLVILFVEYLSYYSKESGNPSKGAAYVFMRRRLSCFNSHALPEEYLTLLSRWCRCLVGSDDMSELLTASPPWLLFRLTPSIFKLLIEAFLYGFFDESTLLNAFAYFLRVPLRYNVPCAVNWLVRYTTMTLAKAQYDPKLWSLIFLLVRTLHMLFMSDACPPLIRSMLAGVVLPLLQNERLVLMTHTSNVNIPVFISTLQSYTDPHLPQSPWIVDVLMMCEDAKPWYSLVQRIGIITLQGLDTCIARQLLGVALQTRAEQVWTIKLLAAVFSLLHLNSKATKPLSLVRVILLQWDASSSKPEHIRNLGRILVLSVLLSKNLPASADALETVFGSLLTPSAEPLAHILRSET
Length763
PositionTail
OrganismMalassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Malasseziomycetes> Malasseziales> Malasseziaceae> Malassezia.
Aromaticity0.09
Grand average of hydropathy0.219
Instability index58.76
Isoelectric point6.25
Molecular weight85455.51
Publications
PubMed=18000048

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24808
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.81|      21|      21|      29|      49|       1
---------------------------------------------------------------------------
   29-   49 (38.07/25.85)	WPEIESDAPHLPSVLHAIHIL
   53-   73 (31.74/20.14)	FNAVSSPSPRAKATLQSLNAL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.73|      54|      87|     481|     553|       2
---------------------------------------------------------------------------
  481-  548 (85.41/66.29)	ASPPWLLFRLTPSIFKLLIEAFLYGFFDESTLlnafayflrvplryNVPCAVNWLVRYTTMTLAKAQY
  571-  624 (94.32/53.01)	ACPPLIRSMLAGVVLPLLQNERLVLMTHTSNV..............NIPVFISTLQSYTDPHLPQSPW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.64|      12|      91|     114|     130|       3
---------------------------------------------------------------------------
  114-  130 (16.56/22.76)	VWRQVesSGGrrpVLPP
  208-  219 (27.08/15.26)	VWRHV..IGG...LLPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     167.39|      36|      87|     355|     390|       5
---------------------------------------------------------------------------
  317-  349 (31.36/16.54)	................LLHNPSACgNLIERAVKEPCLQL.....VLAME...lNHLL
  355-  390 (62.69/41.32)	FMSAE...........FMHMHAIC.YLLQSGAPQNLDML.....CLYMG....QQLL
  393-  420 (36.50/20.61)	TLVHV...........LSHMDQS....MWSHPDDALNLV.....ILFV.........
  425-  479 (36.85/20.88)	YYSKEsgnpskgaayvFMRRRLSC.FNSHALPEEYLTLLsrwcrCL.VGsddmSELL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.87|      11|      15|     685|     695|       6
---------------------------------------------------------------------------
  685-  695 (18.74/ 9.31)	LLHLNSKATKP
  703-  713 (20.13/10.48)	LLQWDASSSKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.63|      29|     575|      75|     106|       8
---------------------------------------------------------------------------
   75-  106 (48.50/35.51)	NGLTTPLNDDLFGE..QQPAASVpslWASR...AFFS
  651-  684 (42.13/23.20)	QGLDTCIARQLLGValQTRAEQV...WTIKllaAVFS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24808 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA