<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24806

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMKGNAVTCEYATVSLASQAKVRWRRYVAPRGVALDEIAEVAQTLQAALIASPKTREPAVLWLTHLRLPFYAVEGTDMPEALWMFVWSDTTLSVELENYLQALLLHSSGEYIVQQQHHPGSAAHAADPLPQSHTFFLRAVCNAIADRLHDGFNTRVAGGLLRLNPFSCEFQAPSLACYTTFRAYTSQHTLYVMSNTEYTQWRPFDLRITPADAVPRDVVLGETQVRMLPSLQRATLLSTCVETQAEPHMSNVLSVLNDSFLHLSNQDSSHVAVLRISIREPPPSLPVDASDMRTGVNPRTTLCTVLWPLALCLRDESSHTETTRTPWPLYSAAQLLDSETWHTNSDAAEPDVMSEAGPGLQQSPLCTIASERIAEPSHMQTPNKNSPLSLMQDNMEGVFSSIGQLTQDELSFFEMPTTLSAFIEPPNAHAQPVCDPMGSSNIPTPTSPTPMTCPDALTHKYDEHGKFFTPGGRWRSSDDVTRIGLSPRFSFTSPQSASGNMAAWTSISPMFQSDESNDDDETDFAGTPSIVQRSLCLTRLRSSTAYPEQKPTYSRVSETRAMRMRLAWTALYAANAQHSLNLPRHAEPVLTAQVQSEPLPIPSIFAGCQQSFVQIHITALPFWTQLGLQPVAGKRMIHAHLVLVDSTVPLESARAWLQALADQYSAQSLGTLTLGHVWQYKEGTWTHGSSPSLAKGHTVVILVYDDRRACERLYSAWPEPRADVTLLPVPQNDLLAYPIRQSLVWAAYEDPLHRVFQLAPRTFEVCHYLREKISFALAWPLQSSHDPLHQGAVLHVAYDRLAPVVRVVCTDDRAQRLVCRVWDASDAQTDILHAWEVICGVLADTFATWHVVIGRFSDMPAEEMQTWKFVISRKESFILSVGLLCLEPNAWPLIHTQPHAQPQVVYMADMPMALHTGQPLPVLRSAYMTHGVYAVHLLQSHDTYEMDAYFHDIVLHLYALECMTKARWPGLDVCLPWHFAILACA
Length984
PositionKinase
OrganismMalassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Malasseziomycetes> Malasseziales> Malasseziaceae> Malassezia.
Aromaticity0.09
Grand average of hydropathy-0.134
Instability index55.69
Isoelectric point5.75
Molecular weight109786.65
Publications
PubMed=18000048

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24806
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.93|      13|      19|     842|     854|       2
---------------------------------------------------------------------------
  842-  854 (25.13/15.84)	ADTFATWHVVIGR
  860-  872 (24.81/15.54)	AEEMQTWKFVISR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.54|      19|      19|      44|      62|       3
---------------------------------------------------------------------------
   44-   62 (31.01/19.04)	LQAALIASPKTREPAVLWL
   65-   83 (34.01/21.72)	LRLPFYAVEGTDMPEALWM
  312-  326 (22.52/11.49)	LRDESSHTETTRTP...W.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.64|      11|      19|     951|     961|       4
---------------------------------------------------------------------------
  951-  961 (20.65/14.70)	DIVL..HLYALEC
  971-  983 (16.99/10.67)	DVCLpwHFAILAC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.63|      21|     154|       4|      26|       5
---------------------------------------------------------------------------
    4-   26 (33.87/29.06)	NAVTCEYATVSLASQAKvrWRRY
  163-  183 (41.76/28.80)	NPFSCEFQAPSLACYTT..FRAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     203.51|      46|     153|     425|     471|       6
---------------------------------------------------------------------------
  357-  402 (65.08/35.30)	PGLQQSPLC.TIASERIAEPSHmQTPnKNSPLSLMQ..DNMEGVFSSIG
  425-  471 (85.70/53.05)	PNAHAQPVCdPMGSSNIPTPTS.PTP.MTCPDALTHKYDEHGKFFTPGG
  494-  527 (52.73/27.18)	QSA..........SGNMAAWTS.ISP.MFQSDE.SNDDDETDFAGTP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.90|      16|      19|     206|     223|       7
---------------------------------------------------------------------------
  206-  223 (23.53/20.43)	RITPadAVPRDVVLG...ETQ
  225-  243 (22.37/12.01)	RMLP..SLQRATLLStcvETQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.87|      19|      19|     657|     675|       8
---------------------------------------------------------------------------
  657-  675 (31.39/15.98)	QALADQYSAQSLGTLTLGH
  678-  696 (35.48/18.92)	QYKEGTWTHGSSPSLAKGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     226.34|      55|     170|     531|     586|      10
---------------------------------------------------------------------------
  531-  586 (93.29/58.36)	QRSLCLTRLRS..STAYPEQK..PTYSRV.SETR....AMRM..RLAWTAlYAANAQHSLNL.PRHAE
  705-  763 (75.19/42.36)	DRRAC.ERLYS....AWPEPRadVTLLPV.PQNDllayPIRQ..SLVWAA.YEDPLHRVFQLaPRTFE
  781-  833 (57.87/30.83)	QSSHDPLHQGAvlHVAYDRLA..PVVRVVcTDDR....AQRLvcRV.WD...ASDAQTDI....LHA.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      28.18|       8|      16|     125|     135|      12
---------------------------------------------------------------------------
  125-  135 (11.77/14.23)	ADPLpqsHTFF
  144-  151 (16.41/ 7.75)	ADRL...HDGF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24806 with Med13 domain of Kingdom Fungi
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