<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24801

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDHTTESGFSDVPLEQLLKELPVEDSDLVPLTVLVERITNNAYQTIQSLSDTLPSLPSGAKRVKIFRTALELRRLFIKLLVIVRWSKDVDLFNRVRNVVALLVEQQWAHEDVFSGLTQVRKIMPNARISDADFVTAIDVLRTGTYRRLPSCIKDSAVSPKPIDNEEALHTLANLDNVLQIRFTCSDYVPMGLRLQCIQDGKAYLEAPDLYKMCLTVSGPEEHDRWWLLDFEFLDKLGQQESLVPNLTEPFLEHVLESAELILSSEYNKEEQSTLMRLHDMLEQEALQRQLHILHHQTQRMAQFSWGKNIRYSLDPMAHILEVYYWVSHSEGMKDKSKLQGRLGLQIVSQPLKGQGRILSDILSGNQSPIHQNNIQVQWHIDPSLQIYLSSKEKECKLECLDMETLLLKCISMHTLALMKHLESDVQSHEGLGAGNPSLCRLCTHNDSGYGPRYSLELRLSDTVHVMMYIPTISGKIGLRLLDRNENRNNMILSLSQSQNATLQRMADQIQADLSSFADTLFTFRLQCLTRSLQLQISWLGLPCSTSIALRSEELKKLSLQNGRPLLYVPLGIVPGYYLMLYFAPDQQLGMAMVLIASVIENGKALQVINSVKWLEKTYLSLFIVSGASLINRSIPPEGDSTAKDRIRTEELELALNYCLAIVVYSHLEEQLRLKLVPFTLVGGTTSSPSSPTSGHDPLLPSLCVQSKKLLPSFEDLVSPNMSLQLCDWWLPSKRRVVISLKVRLNGEFNMEEVQLYDGMVLNLQTGILTFSCYDLTAALIKFQQSWDQIARMCTLINASTIWNQPDFHVSLESLALQQVKFVYGPEGYGKDHKRYTIQVTFEKMDRANLARYTLDFGLQTNDKNHNERKALNPHQHILKILERNLNSLDKNTDIVWQLMFQVRTSKIF
Length908
PositionTail
OrganismMalassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Malasseziomycetes> Malasseziales> Malasseziaceae> Malassezia.
Aromaticity0.07
Grand average of hydropathy-0.171
Instability index50.95
Isoelectric point6.17
Molecular weight103509.18
Publications
PubMed=18000048

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24801
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.21|      50|     158|     373|     426|       1
---------------------------------------------------------------------------
  309-  362 (75.03/61.82)	IRYSLDPMahiLEVYYWVSHSEGMKDKSKLQgRLGLQIVS.QPLKGQGRILSDIL
  376-  426 (81.17/71.97)	VQWHIDPS...LQIYLSSKEKECKLECLDME.TLLLKCISmHTLALMKHLESDVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.83|      35|     384|     448|     486|       2
---------------------------------------------------------------------------
  448-  486 (57.40/49.44)	GYG...PRYSLELRLS..DTVHVMMYiptiSGKIGLRLLDRNEN
  827-  866 (53.43/35.65)	GYGkdhKRYTIQVTFEkmDRANLARY....TLDFGLQTNDKNHN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     235.10|      55|     502|     185|     251|       3
---------------------------------------------------------------------------
  185-  239 (100.08/46.50)	SDY..VPMGLRLQCIQDGKAYLEAPDLYKMCLTVSGPEEHDRWWL.............LDFEF.LDKLGQQ
  693-  756 (71.35/29.85)	SGH..DPL.LPSLCVQSKKLLPSFEDLVSPNMSL...QLCD.WWLpskrrvvislkvrLNGEFnMEEVQLY
  771-  817 (63.66/39.42)	SCYdlTAALIKFQQSWD........QIARMCTLINAS...TIWNQ.............PDFHVsLESLALQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.23|      22|     101|       6|      29|       5
---------------------------------------------------------------------------
    6-   29 (32.96/27.04)	ESGFSDvpLEQLLKELP...VEDSDLV
  110-  134 (34.27/20.80)	EDVFSG..LTQVRKIMPnarISDADFV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24801 with Med14 domain of Kingdom Fungi
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