<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24783

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNFYALTDLCGIKWRKFVNGERPNASSDPLADPILRSYSRCIQADMLCVWRRVQSTKTDHADPNALTFEMTTSTKVHPPLSLAAAKELWIFWYGEEPDLSELVDAELLRVAANQALWNGTWKGALTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSSDRLFGRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLTEAAAAFAAASSPPGSNGSAASAGGAVPNPGQDPNGASMDGLDGGEGAAKAAPPPHARKVMLAPFGIAGILTGNSYKASDPIAEKILEDWASFFPLCNKDNTDVPPVVEVVSGGHKMYHPTNYVLVTDLDDMEHMEFVEMQKMQSSVAGAAAESAVLASLSCPPGAASAPSSMGAAPSATAVPLGPASLNAPALAGAGVGATASSAAKEISRKAAPQAVSALERLAFQPYYDQRPTSGFTFNTNNTHIPASAAVEMPERTWQDCVMNTLHVDAAAAAAAVASSTPASGTGSLSADGDENEQNKPPQDSKQLVQQQIQQQQQRQKLWNFVDPMQKAPCICTNAQCNSSSSISNISNNKRPQQPLGSPALRAAVTGGSGNKSSSSSSSSSSSSSSSSSYQQQHYHQQHLQQQQQQRPGTPVLPATAATSSHHSSSLSNTSASNSSAATPRRHNVPFHKRLLHSLASTASSTASTFRAKNHSNTTTDTNIPKQRHLGNTPHGTPHGGASTYSRNSLGGDSSMPVASVESPATPAPSPHPNSAHSQPTSVPPAEQLLNMSPHAPTSVSNLQQPPTPIDHLLDKNTPAPTPTDQHDSKSITASPYVHQTPSVEPPSYTDHAAGGGPAGGQGLGTGPGSVPAQQPATPTAATSAGGAGSGGPSNAIGANAVGTISVKKLEMQQQTPSAAMAIKQEPGAQGRGVGGVTSTTEALNNFKRLYNPPKLTLKDPDSFYDEEWLKEVIYDFQYQEYWDYSTVKRPKMEKQRRPRYAKNLYEGQNHVKPVMPSPGSVYGSQLLSLDESASQAGGRGGGGQAAGSSGGGLVGIANSTASGSDVEADGSSFFQGLNIKTEPGLHSPSCKETSKSSGGNSSGGGSGSGGNLFTAEGLNPSLNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGGCSAVTNTIEDLKRSTAVASAAVAAAAAAAASGAGNIQAEDLTKMFPTPPSHEQQHPNSSPCQTDVVMTDLSVDTTTTIITSSITTTCNTTITSSINTTTTACSNPSNSIMLAAAQAPVTVVAIQTVSKMVKQEYNLELGSPMEEPINDWDYVYRPPQQEKFVGSTRYAPLTNLPSQTQPPLTLPTGCFYQPTWSSHKSRAATLAKAAAAQQQQHQKHQALQQRIQLHQQKLQQLQLQNQQQQQAAAAAAAAASGGVGHQKHQHQHLHDLLSAAPRTPLTPSTVPQPLSSGGSQYLLNQLNCPQAPPGASMQQLMHRAGMSPISPGPGMGPYAARSSPMSRATPTHPPPPYPYDLAVASPATSTSSYLNRPLHSQEHPHMHGLGGGATGVVGHGTGGGGHMGMVAYTGDAGIVSGGTAMAAGSSSLLQELPEVNSVLVNILLYDTALNVFRDHNFDSSSVCVCNADTQKIGNIRGADSGVYVPLPGVSFNPFPSGAGGALAGQRMLNGPSSAGFGGMRMISAFGGSPASASMPGAGSGHGHGPNGGSNSSSCTPPSSNPHITGYVDDDPVECTCGFSAVVNRRLSHRAGLFYEDEVEITGIADDPGRNKQPTLLSIIQSLSRKNQNKQGPGETSSALDKIGAGGLPNGQLEQLGHAVFDLLLDQCSIIQTSSSSVHRALQSHRRRMSRQRRIFGNNGAPTASLASIANVLEFMDAHDVISLALEQSRLAFENQRMDNMMDFHGNGSSSSHQQQQLTAFHAPPPALRHKLAGIGAGRLTVHKWPYLPVGFTRSNKEIVRTMNAIQPMLQNAFHCKSRGGSGSKDASSYNTVSGPLTWRQFHRLAGRASGQCEPQPIPSVVVGYEKDWISVAPHSIHYWDKFLLEPYSYARDVVYVVVCPDNEHVVNCTRSYFRELSSTYEMCKLGKHTPIRGWDGFLQVGAARNNVPADRETTPLDDWLRTLEHAALAEQIRRYAVAFIHQLAPYLSRVPNDKTLLNPPDGSGNSHSKGGSSCSSNSSSVSGLPGGDLPTDNIKLEPGTEPQVQPMETNEIKQEPGVGKGGTAAGETKPTLILGDPLGMGETLEDINPSAIVLYVVNPFTFASDSCELERLALIALLRCYAELLKAVPDSVRSQMNIQIISLESVMELGPCGNRKRFSDEIRCLALNIFSQCRRHLVHAQSVKSLTGFGTAANMEAFLKTKDEPNRRAYKMYTAPFVLAPMHERNDKTDFSRSAGSMHGQNEHRYSVMYCNYCLSEDQAWLLATATDERGEMLEKICINIDVPNRARRRKAPARYVALKKLMDFIMGIISQTSQMWRLVIGRIGRIGHSELKSWSFLLSKQQLQKASKQFKDMCKQCTLMYPPTILSACLVTLEPDAKLRVMPDQFTPDERFSQISMQNPLATPQDVTCTHILVFPTSAVCAPFTRQFQNEPQVDDDFLTFEEEGNEDFSDADIGDLFWDTHMDRVSNHGSPGRMDDNRSWQSAGGNNFKCTPPQEVEEVGSLNQQPISVGYMVSTAPTGRMPAWFWSACPHLEDVCPVFLKTALHLHVPSIQSADDILNSTNAHQSGNDHPLDSNLTADVLRFVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIA
Length2768
PositionMiddle
OrganismDrosophila melanogaster (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.06
Grand average of hydropathy-0.413
Instability index52.68
Isoelectric point6.35
Molecular weight295728.05
Publications
PubMed=10731132
PubMed=12537568
PubMed=12537572
PubMed=12537573
PubMed=12537574
PubMed=16110336
PubMed=17569856
PubMed=17569867

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24783
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.44|      16|      20|    1465|    1481|       1
---------------------------------------------------------------------------
 1465- 1481 (29.42/16.97)	PISPGPGMgPY.AARSSP
 1487- 1503 (31.02/13.42)	PTHPPPPY.PYdLAVASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.89|      17|      21|    1652|    1672|       2
---------------------------------------------------------------------------
 1656- 1672 (29.57/ 6.43)	GFGGMRMISAFGGSPAS
 1677- 1693 (35.32/ 9.87)	GAGSGHGHGPNGGSNSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.69|      21|      21|     385|     405|       3
---------------------------------------------------------------------------
  395-  416 (27.46/ 9.85)	PSSMGAAPSAT......avpLG..PASLNA
  417-  446 (23.68/ 7.28)	PALAGAGVGATassaakeisRKAAPQAVSA
  864-  887 (27.54/ 9.90)	PATPTAATSAG......gagSGGPSNAIGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     209.44|      39|     219|    1165|    1215|       4
---------------------------------------------------------------------------
  228-  260 (39.57/10.23)	.AAAAFAAASS....PPGSngsaASAG.....G...AVP.N...PG...QDPN..
  498-  535 (45.01/13.04)	AAAAAAAVASStpasGTGS....LSAD.....GDENEQN.KP..PQDSKQ.....
 1165- 1203 (70.93/40.68)	AVAAAAAAAAS....GAGN....IQAE.....DLTKMFP.TP..PSHEQQHPNSS
 1388- 1433 (53.92/15.59)	AAAAAAAAASG....GVGH....QKHQhqhlhDLLSAAPrTPltPSTVPQ.PLSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.70|      21|      21|     743|     763|       5
---------------------------------------------------------------------------
  743-  760 (30.64/12.28)	...........SMPVASVESPATP..APSPH
  761-  783 (27.35/10.01)	PNS......ahSQP.TSV.PPAEQllNMSPH
  785-  812 (26.71/ 9.56)	PTSvsnlqqppT.PIDHLLDKNTP..APTPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.18|      19|      21|    1520|    1538|       6
---------------------------------------------------------------------------
  840-  854 (23.67/ 8.63)	....HAAGGGPAGGQGLGT
 1520- 1538 (39.82/20.06)	HPHMHGLGGGATGVVGHGT
 1543- 1560 (33.69/15.73)	HMGMVAYTGDA.GIVSGGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     218.33|      38|      38|     645|     682|       8
---------------------------------------------------------------------------
  576-  614 (52.68/23.95)	SNISNNKRPQQPLGSP.............aLRAAVTGG..SGNKSSSSSSSSSS
  615-  666 (50.32/22.48)	SSSSSSSYQQQHYHQQhlqqqqqqrpgtpvLPATAATS..SHHSSSLSNTSASN
  667-  705 (49.49/21.97)	SSAATPRRHNVPFHKR.............lLHSLASTA..SSTASTFRAKNHSN
  706-  731 (33.06/11.75)	TTTDT....NIPKQRH..............LGNTPHGT..PHGGAS........
 2131- 2160 (32.78/11.58)	..........VPNDKT..............LLNPPDGSgnSHSKGGSSCSSNSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.86|      14|      23|    1205|    1221|       9
---------------------------------------------------------------------------
 1205- 1221 (21.03/17.49)	CQTDVVMtdlSVDTTTT
 1231- 1244 (25.83/13.17)	CNTTITS...SINTTTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.22|      14|      24|    1703|    1716|      10
---------------------------------------------------------------------------
 1703- 1716 (27.75/20.37)	HITGYVDDDPVECT
 1729- 1742 (25.46/17.98)	HRAGLFYEDEVEIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     369.53|     116|     865|    1748|    1867|      11
---------------------------------------------------------------------------
 1748- 1867 (186.89/116.49)	PGRNKQPTLLsiiQSLSRKNQNKQGPGETS..SALDK..IGAGGL....PNGQLEQLGHAVFDLLLDQCSIIQTSSSSVH.RALQSHRRRMSRQRRIFGNNGAPTASlASIANVLEF.MDAHDVIS.LALE
 2614- 2740 (182.64/104.02)	PGRMDDNRSW...QSAGGNNFKCTPPQEVEevGSLNQqpISVGYMvstaPTGRMPAWFWSACPHLEDVCPVFLKTALHLHvPSIQSADDILNSTNAHQSGNDHPLDS.NLTADVLRFvLEGYNALSwLALD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.19|      15|     747|    1278|    1294|      12
---------------------------------------------------------------------------
 1278- 1294 (25.18/22.65)	YNL.ELGSpmEEPINDWD
 2061- 2076 (27.00/15.56)	YEMcKLGK..HTPIRGWD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.58|      11|      22|     970|     981|      13
---------------------------------------------------------------------------
  970-  981 (18.68/16.12)	YWDYSTVKrPKM
  994- 1004 (21.90/13.15)	YEGQNHVK.PVM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.38|      20|     614|    1005|    1031|      15
---------------------------------------------------------------------------
 1005- 1031 (30.99/30.40)	PSPGsvygsqlLSLDESASQAGGRGGG
 1626- 1645 (39.39/21.52)	PLPG.......VSFNPFPSGAGGALAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.48|      20|      23|     266|     285|      17
---------------------------------------------------------------------------
  266-  285 (36.35/21.29)	GLDG.GEGAAKAAPPPHARKV
  291-  311 (30.12/16.11)	GIAGiLTGNSYKASDPIAEKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.50|      20|      49|    1089|    1110|      19
---------------------------------------------------------------------------
 1089- 1110 (33.43/21.18)	NSSGGGSGSGGNlfTAEGLNPS
 1139- 1158 (37.07/17.71)	NPSNGGCSAVTN..TIEDLKRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.20|      34|    1280|     902|     949|      23
---------------------------------------------------------------------------
  902-  949 (50.80/54.23)	QQTPSAAMAIKQEPgaqgrGVG.GVTSTTEalnnfkrlyNPPKLTLKDP
 2184- 2218 (59.40/32.49)	QVQPMETNEIKQEP.....GVGkGGTAAGE.........TKPTLILGDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.34|      15|      21|    1311|    1327|      25
---------------------------------------------------------------------------
 1311- 1327 (23.31/14.84)	YAPltNLPSQTQPPLTL
 1333- 1347 (28.03/12.47)	YQP..TWSSHKSRAATL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.50|      19|    2177|     147|     166|      27
---------------------------------------------------------------------------
  147-  166 (30.06/23.31)	RSLL.FKALHNlMERFVLTKD
 2325- 2344 (29.45/17.71)	KSLTgFGTAAN.MEAFLKTKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.73|      18|    1419|     449|     469|      30
---------------------------------------------------------------------------
  449-  469 (28.98/27.83)	RLAFQpyyDQRPTSGFTFNTN
 1870- 1887 (35.76/22.43)	RLAFE...NQRMDNMMDFHGN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24783 with Med13 domain of Kingdom Metazoa
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