<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24777

Description AGAP005156-PA
SequenceMDAPMSGKAQIGYSHTADEHSDRETDHGRDGESSDEGVNVNRPSPDAKMTSGMEFGRSPDHHSELSQATAAAAAAAAAAAAAAQFGANHPLGVLSNLTALNMNVPGLSGLASGLAAGHHGDVLEKLKMQVRDMKVGALMGEQMAADFAALHAASSPFGAALAASTANGAGNGMGMFGSGRDDARGGSGGSGSSGGSMNVGSGGGGGGGAAGGGSQAQTGPQNGSNFSFTLPNAPISKDGNPGSNSSTSSETSNSSQQNNGWSFEEQFKQVRQLYEINDDPKRKEFLDDLFLFMQKRGTPINRLPIMAKSVLDLYELYNLVIARGGLVDVINKKLWQEIIKGLHLPSSITSAAFTLRTQYMKYLYPYECEKKNLSTPAELQAAIDGNRREGRRSSYGQFDSPSVQRSPIPQGISQMPPLSLVSHVNQQQHHHRLLPPVGQIPNMLPAEFEQRMLNYIKMFQPKEMGRSQSPDKLSALNAIDISRVALWNMYNPSPNSPPNSLNTSPENNMQSALDLSESPDHAMAAIKRERDHPVDFSDPRDYGNGLGPPAKRSHHHHHSHHHNRSLTPQKLNSSSQDEDDARSDSTPVNLRENGSHGRRATLDDDGDDEEDEMEDETTDEDMLRASFAAAAAAAAVNQHPLALSLADHHLQQQQQQQQQQQQQRERERIQQQVAAQQQQQQQQQREQQHSLATLDLSILDRERLRCDSADKLKRQSQQQQQQQQQQQQQHLLDQHHLHQRQLQHQQQARVARELRKHENGDRLSLTPDSSELLHHSKNHLSTSGGAGGAGSDPFSSPLGITGMQFKLISRGDASKGDQKLVVTMEFNGVQYEGVLFANPLSSANLSAPPASTPPSSSVSATSASPIGSMVSPVKSSAAAHIASPLDERDSSASANIDVAAMGSALAATATVTSNASSNATCIQQQPLDGAVSPPAALSITAPSVGASSPARSLVS
Length955
PositionKinase
OrganismAnopheles gambiae (African malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.04
Grand average of hydropathy-0.685
Instability index54.43
Isoelectric point5.95
Molecular weight102126.20
Publications
PubMed=12364791

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
DNA binding	GO:0003677	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24777
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.79|      12|      24|     651|     664|       1
---------------------------------------------------------------------------
  651-  662 (26.02/ 6.73)	QQQQQQQQ..QQQQ
  723-  736 (18.77/ 7.74)	QQQQQQQHllDQHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      99.80|      14|      16|     185|     198|       2
---------------------------------------------------------------------------
  168-  181 (24.53/ 9.22)	GAGNGMGMFGSGRD
  185-  198 (26.90/10.83)	GGSGGSGSSGGSMN
  202-  215 (24.80/ 9.41)	GGGGGGGAAGGGSQ
  219-  232 (23.56/ 8.57)	GPQNGSNFSFTLPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.46|      21|      36|     663|     683|       3
---------------------------------------------------------------------------
  663-  683 (39.74/22.24)	QRE..............RERIQQQVAA....QQQQQQQQ
  684-  722 (25.07/11.17)	QREqqhslatldlsildRERLRCDSADklkrQSQQQQQQ
  737-  750 (23.64/10.10)	LHQ..............R.....QL......QHQQQARV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      99.27|      23|      23|     510|     532|       4
---------------------------------------------------------------------------
  525-  545 (27.55/13.74)	AIKRERDH........pVDFSDPRDYGN.G
  549-  573 (29.41/15.23)	PAKRSHHHhhSH...H.HNRSLTPQKLN.S
  574-  600 (23.20/10.26)	SSQDEDDA..RSdstP.VNLRENGSHGRrA
  601-  622 (19.11/ 6.99)	TLDDDGDDeeDE...M.ED..ETTDEDM..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.49|      22|      23|     883|     904|       5
---------------------------------------------------------------------------
  839-  860 (25.06/11.41)	.PLSSaNLSAPPA.STPPSSSVSA
  883-  904 (33.18/17.95)	SPLDE.RDSSASA.NIDVAAMGSA
  925-  945 (24.26/10.77)	QPLDG.AVSPPAAlSITAPSVG..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.14|      23|      23|     783|     805|       6
---------------------------------------------------------------------------
  783-  805 (41.16/21.91)	SGGAGGAGSDPFSSPLGITGMQF
  809-  831 (38.98/20.37)	SRGDASKGDQKLVVTMEFNGVQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.75|      22|      23|     267|     289|       7
---------------------------------------------------------------------------
  267-  289 (34.76/32.09)	FKQVRQLyEINDDP.KRKEFLD..DL
  292-  316 (29.99/20.87)	FMQKRGT.PINRLPiMAKSVLDlyEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.62|      21|     553|      71|      91|       8
---------------------------------------------------------------------------
   71-   91 (35.97/17.60)	AAAAAAAAAAAAAQFGANHPL
  100-  118 (22.27/ 8.09)	LNMNVPGLSGLASGLAAGH..
  625-  641 (24.38/ 9.56)	..ASFAAAAAAAA..VNQHPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.67|      21|      27|      14|      36|      11
---------------------------------------------------------------------------
   14-   36 (33.04/22.97)	SHTADEHSDREtdHGRDGESSDE
   44-   64 (39.64/21.59)	SPDAKMTSGME..FGRSPDHHSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.66|      12|      34|     340|     351|      12
---------------------------------------------------------------------------
  340-  351 (20.27/12.42)	KGLHLPSSITSA
  371-  382 (19.39/11.53)	KNLSTPAELQAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.92|      11|      15|     753|     764|      13
---------------------------------------------------------------------------
  753-  764 (14.89/11.58)	ELRKHENgDRLS
  771-  781 (20.03/10.28)	ELLHHSK.NHLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.72|      10|      20|     139|     148|      14
---------------------------------------------------------------------------
  139-  148 (18.56/ 9.67)	MGEQMAADFA
  157-  166 (16.16/ 7.53)	FGAALAASTA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24777 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ERLRCDSADKLKRQSQQQQQQQQQQQQQHLLDQHHLHQRQLQHQQQARVARELRKHENGDRLSLTPDSSELLHHSKNHLSTSGGAGGAGSDPFSS
2) GNGMGMFGSGRDDARGGSGGSGSSGGSMNVGSGGGGGGGAAGGGSQAQTGPQNGSNFSFTLPNAPISKDGNPGSNSSTSSETSNSSQQNNGWS
3) MDAPMSGKAQIGYSHTADEHSDRETDHGRDGESSDEGVNVNRPSPDAKMTSGMEFGRSPDHHSELSQATA
4) WNMYNPSPNSPPNSLNTSPENNMQSALDLSESPDHAMAAIKRERDHPVDFSDPRDYGNGLGPPAKRSHHHHHSHHHNRSLTPQKLNSSSQDEDDARSDSTPVNLRENGSHGRRATLDDDGDDEEDEMEDETTDEDMLRASFAAAAAAAAVNQHPLALSLADHHLQQQQQQQQQQQQQRERERIQQQVAAQQQQQQQQQREQQHSLATLDLSILD
702
170
1
487
796
262
70
700










Molecular Recognition Features






MoRF SequenceStartStop




NANANA