<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24776

Description Uncharacterized protein
SequenceMDGSTWLNNSLNMEERAKNVNDLLQVLMDINDINGGNNDTAEKMKIHAKNFEAALFAKSSSKKEYMDNMREKVTAMRNTLNSRKKEVVSKSSGNNNPSNTSTNTNTNVNVNANSNTSNNNTSSAANSDKMGNFPLNMNSQMFLNQQAQLRQQAAQQLRTQQQQQRPQLTPQQQQIINQMKVAPIPRELLSRIPNIPPGVNTWQQITELAQQKVLSQQDMHIAKEIYKVHQQLLYKSKLQQQQQQQAQAQAQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQVQAQAQAQAQQQQQKGNQAQNPGNRPTEVPNVLGQINQIFTPEEQRALLQEAMEACKNFRKTQYGNNMTDANRQNFIRKYINQKALRKIQSMRMAQMGNKNANSNTNNTNINTNTNANNNNNNGGNNNNNNNNINNNNTNINRNNNPPLINNNTVNNNGNQITTNPQANVNAQKNITGLQNNNQFIPNQNNNNSNQFNANVQNNNQQQQQQQQQRNQQSQQRQNLLQALAPTQQDIEVVKKVSAEAARIPLRLSDLTNTLSVQEREEIKRKLQLNQQLFAQVSNYAPQVYIFTKSENFLKEVLQLRIFVKEILEKCSKGIYVVKLDTVDKLIMKYQKYWESMKIQLLRRQQLIQRQQQAAGNNMPQNQQQSQTQPQQQQPQQQQQPPQQQPQPQQQQQLPRQQISTGNNLSQQQQRVQGSLQHIQQQMQQKQRQMAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQVQAQAQAQAQAQAQAQPQVQPQTQGPNHASQPQIPNSDSSKAQGYNQMMNNNSVDQNAATANVTANRGIVGNIDLTASQDISKMSPNTAVSPGKKETKRPISGKVKKAKKLSPASTTSVQNTPIPISPSVVKSTAGIQGTPSPLTTTDISTSRSSLNVSQTSSGENPFNEEEALLKNLNARKAEIISRYKHRQEIFGKSSIDMFLGTLADSMGIKDDDIDLVNTIPQHIIDTTNGTGKKKFTKTQQKSRDQDVVNVQIKSNKLIMQSKNDPESRNYKIDDFAISSIFNSLSGFNNSKFVNLFEVATSTGSGTKSSNNTNANSSKKRKLEELEVSPANSNSSLMSDSKKIKIDSPEDLFVTKPESTQEKLVDKSFIPENIWNWSQWAEL
Length1165
PositionTail
OrganismVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Vanderwaltozyma.
Aromaticity0.04
Grand average of hydropathy-1.137
Instability index52.67
Isoelectric point9.84
Molecular weight131320.57
Publications
PubMed=17494770

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
RNA polymerase II activating transcription factor binding	GO:0001102	IEA:EnsemblFungi
TFIIE-class transcription factor complex binding	GO:0001095	IEA:EnsemblFungi
TFIIH-class transcription factor complex binding	GO:0001097	IEA:EnsemblFungi
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of invasive growth in response to glucose limitation	GO:2000219	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi
regulation of establishment of protein localization to chromosome	GO:0070202	IEA:EnsemblFungi
RNA polymerase II preinitiation complex assembly	GO:0051123	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24776
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     291.74|      19|      19|     251|     269|       1
---------------------------------------------------------------------------
  145-  163 (31.70/ 6.22)	QQAQLRQQAAQ.QLRTQQQQ
  239-  258 (36.48/ 8.55)	QQQQQQQAQAQaQQQQQQQQ
  259-  278 (40.21/10.37)	QQQQQQQQQQQqQQQQQQQQ
  279-  297 (44.61/12.51)	QQQQQQQQQQQ.QQQQQQQQ
  298-  315 (36.15/ 8.38)	QQQQQVQ.AQA.QAQAQQQQ
  504-  522 (33.81/ 7.24)	QNNNQQQQQQQ.QQRNQQSQ
  670-  686 (33.76/ 7.22)	QQQSQTQ..PQ.QQQPQQQQ
  687-  705 (35.02/ 7.83)	QPPQQQPQPQQ.QQQLPRQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.65|      15|      15|     739|     753|       2
---------------------------------------------------------------------------
  752-  767 (26.64/ 7.14)	AQaQAQAQAQAQAQAQ
  768-  783 (25.98/ 6.76)	AQaQAQAQAQVQAQAQ
  784-  799 (26.03/ 6.79)	AQaQAQAQAQPQVQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.95|      19|      29|     444|     472|       4
---------------------------------------------------------------------------
  449-  472 (24.64/17.12)	PPLINNNTvNNNGNQIttnpQANV
  485-  503 (34.32/ 7.72)	NQFIPNQN.NNNSNQF....NANV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.58|      26|      30|     352|     377|       5
---------------------------------------------------------------------------
  352-  377 (45.61/21.29)	QEAMEACKNFRKTQYGNNMTDANRQN
  385-  410 (42.92/19.58)	QKALRKIQSMRMAQMGNKNANSNTNN
  808-  832 (41.06/18.40)	QPQIPNSDS.SKAQGYNQMMNNNSVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.18|      23|      28|      89|     115|       7
---------------------------------------------------------------------------
   89-  111 (38.26/24.39)	SKSSGNNNPSNTSTNTNTNVNVN
  122-  144 (39.93/16.45)	SSAANSDKMGNFPLNMNSQMFLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.80|      26|      28|    1096|    1123|       9
---------------------------------------------------------------------------
 1071- 1092 (21.31/ 6.82)	NNSKFVNL...FEVATS.TgSGTKSS.....
 1098- 1123 (42.61/33.77)	NSSKKRKL...EELEVS.P.ANSNSSLMSDS
 1125- 1150 (17.88/ 7.34)	....KIKIdspEDLFVTkP.ESTQEKLVDKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.59|      22|      28|     889|     913|      10
---------------------------------------------------------------------------
  889-  913 (33.01/25.12)	SPASTTSvqnTPIPISPS...VVKSTAG
  917-  941 (32.58/17.09)	TPSPLTT...TDISTSRSslnVSQTSSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.87|      18|      28|    1020|    1037|      11
---------------------------------------------------------------------------
 1020- 1037 (29.82/17.41)	KTQQKSRDQDVVNVQIKS
 1045- 1062 (28.05/15.89)	KNDPESRNYKIDDFAISS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.97|      15|      93|     647|     661|      15
---------------------------------------------------------------------------
  167-  181 (22.70/ 7.76)	QLTPQQQQIINQMKV
  647-  661 (24.27/ 8.93)	QLLRRQQLIQRQQQA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24776 with Med15 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AKNVNDLLQVLMDINDINGGNNDTAEKMKIHA
2) AKSSSKKEYMDNMREKVTAMRNTLNSRKKEVVSKSSGNNNPSNTSTNTNTNVNVNANSNTSNNNTSSAANSDKMGNFPLNMNSQMFLNQQAQLRQQAAQQLRTQQQQQRPQLTPQQQQIINQMKVAPIPRELLSRIPNIPPGVNTWQ
3) QAQAQQQQQKGNQAQNPGNRPTEVPNVLGQINQIFTPEEQRALLQEAMEACKNFRKTQYGNNMTDANRQNFIRKYINQKALRKIQSMRMAQMGNKNANSNTNNTNINTNTNANNNNNNGGNNNNNNNNINNNNTNINRNNNPPLINNNTVNNNGNQITTNPQANVNAQKNITGLQNNNQFIPNQNNNNSNQFNANVQNNNQQQQQQQQQRNQQSQQRQNLLQ
4) RQQQAAGNNMPQNQQQSQTQPQQQQPQQQQQPPQQQPQPQQQQQLPRQQISTGNNLSQQQQRVQGSLQHIQQQMQQKQRQMAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQVQAQAQAQAQAQAQAQPQVQPQTQGPNHASQPQIPNSDSSKAQGYNQMMNNNSVDQNAATANVTANRGIVGNIDLTASQDISKMSPNTAVSPGKKETKRPISGKVKKAKKLSPASTTSVQNTPIPISPSVVKSTAGIQGTPSPLTTTDISTSRSSLNVSQTSSGENPFNEEEALL
17
57
308
657
48
203
529
952










Molecular Recognition Features






MoRF SequenceStartStop




1) ALRKI
2) FIRKYIN
3) VKKAKKL
387
378
882
391
384
888