Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MSENIMGHVKSISSVSLMTDNTNSISTNSLNMIDYNNESNDLSKVQIYNDISEYENTLFKLVESVDKFKPDVKLAHQLIDVDERLFKSLDSFVEYDKISTKLEECDKEAAELDTKTKEILGTLNECHGLLNSLPMLEQVEFEKDIILKQRSKINSKLLLDYATKLSKFTKIPPTFNKGSIGPNNFIWPAEDALRRGMLAMASLHSKELTKLPNEPEEASEPDKSTEPDKSTEPIEEEKITVDNEGDISMGSIVYDGSHKVKENEKAEENEKGSEAEADNMDLDLDLFNPDEF |
Length | 292 |
Position | Middle |
Organism | Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Vanderwaltozyma. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.670 |
Instability index | 34.18 |
Isoelectric point | 4.51 |
Molecular weight | 32982.48 |
Publications | PubMed=17494770 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IEA:EnsemblFungi transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro transcription by RNA polymerase II GO:0006366 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP24770 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 69.05| 22| 39| 220| 242| 1 --------------------------------------------------------------------------- 220- 242 (33.00/22.55) EPDKSTEPDKSTEPiEEEKITVD 262- 283 (36.05/20.30) ENEKAEENEKGSEA.EADNMDLD --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 48.52| 15| 38| 158| 172| 3 --------------------------------------------------------------------------- 158- 172 (26.37/18.47) LLDYATKLSK.FTKIP 197- 212 (22.15/14.51) MLAMASLHSKeLTKLP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 36.29| 12| 43| 85| 97| 4 --------------------------------------------------------------------------- 58- 69 (19.34/11.60) LFKLVESVDKF.K 85- 97 (16.95/15.06) LFKSLDSFVEYdK --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EADNMDLDLDLFNPDEF 2) GSIVYDGSHKVKENEKA 3) IEEEKITVDN | 276 250 234 | 292 266 243 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab