<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24764

Description Uncharacterized protein
SequenceMSEVEKNISTILSGKVKLEQLEDTLGLDDNSRNTVVTAISQAHDSILPLRLQFNDLIRLLSHIEEQPTQTSEEKYLLIRSKLLDLYKNIENLSIDVKQLQPLFQTVSEYSTKYKNKKYQPLETLYQSSTGATTTITSSANTSNGPSVTGSTSAGSAANTPNVSASASTTTKRAKSNAATPSSATNTPNASGASVGTPNSASAGITSGSGITPIPTTGVSAASGSAATTAASISATTPTTTTTTVKKPRKPRQPKKTAAANKKQPVPSPLNSQIPLNTASINNNNTSSAYNNMKANNTNMKMAPNAGPMNNQAQMMGNPSPKNMVNTPLNNMMGSLGGVSQDYGMQLQTPNQPTPLQMQMGQQGIQQQAPPSQQIPQQFNMGNMGNMNNMGNMNSMGNMNNMGNMGNMNNMGNMNNMGNMNNMGNMGNMGNMGNMNNMGNMNNMGNMNNITPASILSMNLSLDNQLPQQQQHPQQIGQQPDQQGNNRMDTNDFDLLDLNNLDFSGGMDFV
Length509
PositionTail
OrganismVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Vanderwaltozyma.
Aromaticity0.03
Grand average of hydropathy-0.682
Instability index37.00
Isoelectric point9.03
Molecular weight54224.04
Publications
PubMed=17494770

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24764
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     166.78|      19|      19|     380|     398|       1
---------------------------------------------------------------------------
  299-  318 (28.32/ 7.18)	MkmaPNAGPMNNQAQM..MGNP
  380-  398 (46.15/16.00)	M...GNMGNMNNMGNMNSMGNM
  401-  419 (46.54/16.20)	M...GNMGNMNNMGNMNNMGNM
  422-  440 (45.76/15.82)	M...GNMGNMGNMGNMNNMGNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.65|      14|      18|     245|     260|       3
---------------------------------------------------------------------------
  247-  260 (24.29/15.13)	PRKPRQPKKTAAAN
  268-  281 (23.36/ 7.53)	PLNSQIPLNTASIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.19|      24|      24|     193|     216|       4
---------------------------------------------------------------------------
  159-  184 (22.05/ 7.76)	...TPNvSASASTT..TkrakSNAATPSSAT
  193-  216 (44.77/23.22)	SVGTPN.SASAGIT..S....GSGITPIPTT
  219-  241 (31.38/14.11)	SAA....SGSAATTaaS....ISATTPTTTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.88|      10|      18|      85|     102|       5
---------------------------------------------------------------------------
   85-  102 (12.74/23.53)	LYKNienlsidvKQLQPL
  112-  121 (20.13/11.44)	KYKN........KKYQPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.88|      10|     109|     361|     373|       7
---------------------------------------------------------------------------
  361-  373 (11.14/11.10)	QQgIQQQapPSQQ
  473-  482 (20.74/ 7.31)	QQ.IGQQ..PDQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24764 with Med3 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PASILSMNLSLDNQLPQQQQHPQQIGQQPDQQGNNRMDTNDFDLLD
2) TGATTTITSSANTSNGPSVTGSTSAGSAANTPNVSASASTTTKRAKSNAATPSSATNTPNASGASVGTPNSASAGITSGSGITPIPTTGVSAASGSAATTAASISATTPTTTTTTVKKPRKPRQPKKTAAANKKQPVPSPLNSQIPLNTASINNNNTSSAYNNMKANNTNMKMAPNAGPMNNQAQMMGNPSPKNMVNTPLNNMMGSLGGVSQDYGMQLQTPNQPTPLQMQMGQQGIQQQAPPSQQIPQQFNMGNMGNMNNMGNMNSMGNMNNMGNMGNMNNMGNMNNMGNMNNMGNMGNMGNMGNMNNMGNMNNMGNMNNI
451
129
496
449










Molecular Recognition Features






MoRF SequenceStartStop




1) FDLLDLNNL
492
500