<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24759

Description Uncharacterized protein
SequenceMATKSINLGGGTGGKNKLVECFEDILEVSSQMLVQQQLKSIQLDNSVISGFNQGQQKVLLEKVTLFHSILDDLEITLNKGKNYVDELTKIGKDKEEERERVRRAEEEKKRLLEEEEKKRLLEEEEKKRLQLEKEKREEEELKKKKKLEEEQELELEKLKEQQQQQQAEKDKSNEENNSNNLTSPTFFLDTPTDLVTDITGSNKSAQTPQQVESNLVTAATSASLDNQSPNLNKLDSSSNKDKQVNNDQQSENNNQTLTTSAFDDPNSLDISMFPGLDGGAFDLGSFGASDMNSLSNNLSTGSNNANNDSNNLSLLASNENQSSTNNNSDTNNNNNNNNESSVPVNTDDYLTLNDFNDLNIDWNTTGDPGDLDLNGFNL
Length378
PositionTail
OrganismVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Vanderwaltozyma.
Aromaticity0.04
Grand average of hydropathy-1.088
Instability index50.44
Isoelectric point4.43
Molecular weight42235.25
Publications
PubMed=17494770

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
cytosol	GO:0005829	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
RNA polymerase II repressing transcription factor binding	GO:0001103	IEA:EnsemblFungi
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi
RNA polymerase II preinitiation complex assembly	GO:0051123	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24759
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.61|      14|      15|     105|     118|       1
---------------------------------------------------------------------------
   94-  112 (16.70/ 6.39)	KEEERErvrraEEEKKRLL
  113-  130 (17.91/ 7.37)	EEEEKK.rlleEEEKKRLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.89|      25|      25|     262|     286|       4
---------------------------------------------------------------------------
  262-  286 (45.36/20.41)	FDDPNSLDISMFPGLDGGAFD...LGSF
  288-  314 (32.56/12.93)	ASDMNSLSNNLSTGSNNANNDsnnL.SL
  352-  376 (44.97/20.18)	LNDFNDLNIDWNTTGDPGDLD...LNGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.17|      13|      20|     225|     237|       5
---------------------------------------------------------------------------
  225-  237 (23.87/12.88)	DNQSPNLNK.LDSS
  247-  260 (19.30/ 8.90)	DQQSENNNQtLTTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.67|      25|      25|     131|     155|       6
---------------------------------------------------------------------------
  131-  155 (36.80/18.81)	LEKEKREEEELKKKKKLEEEQELEL
  157-  181 (39.87/21.03)	KLKEQQQQQQAEKDKSNEENNSNNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.95|      21|      25|      38|      58|       7
---------------------------------------------------------------------------
   38-   58 (34.70/24.19)	LKSIQLDNSVISG....FNQGQQKV
   60-   84 (29.25/19.21)	LEKVTLFHSILDDleitLNKGKNYV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24759 with Med2 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EEEEKKRLQLEKEKREEEELKKKKKLEEEQELELEKLKEQQQQQQAEKDKSNEENNSNNLTSPTFFLDTPTDLVTDITGSNKSAQTPQQVESNLVTAATSASLDNQSPNLNKLDSSSNKDKQVNNDQQSENNNQTLTTSAFDDPNSLDISMFP
2) GSFGASDMNSLSNNLSTGSNNANNDSNNLSLLASNENQSSTNNNSDTNNNNNNNNESSVPVNTDDYL
122
284
274
350










Molecular Recognition Features






MoRF SequenceStartStop




1) LDLNGFNL
2) VPVNTDDYLTLNDFNDLNIDWNTT
371
342
378
365