<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24756
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSDNDSVRLDKEKGIDLALDPNLIALPLYNSSGSPSLKPTLDKEVEGSSENEVQNFKNVDISNKDHLLVNNPYEVFGQMPLDQFIPLILQERGSGFNFADLSEDTLLQEIQNKESSAIDLGEATSDVVDAMDVDFSTDVLGEPTSDINNTTNSEITSKNSDAGLTVGNVDTQNDQVSQEQFIKAKKEMIEGVNLAINESSLALEFVSLLLSSARESAAISSLSPFLKKTVPINSLNSDKIPLEEKTKQDQLALSVLNKGWKLKSLNESRQILKDNYTSISRTLEKEHEYWRKISKYITNKDVIFKLRDKATNQKVLGIKYGYEDSGSTYRRDRGIASLRNNPETGKLELVPLSKGSNEVSYESGNDRFIRVRIYTKIESEDDAVLSGESSFDKIFFETNEQSNSEDIRGQISRLKALIFEKELMYRLKKECTKLISYGVTVENENKIVIELPNERIEIDYLSIQDSSVINHERDAPKINDRRATLILITLRLLLVAMFKKELKQRLESSKRTTNPNIDHDILLIRPVLGKIRHHNHKILLKRILKEHVTVVLDGTTITEVPNDQIPQDKSETITSAVDIHIKKLSKELDAYSELLQIPISNFKIELPNKGRLEITLKSPNYCNATTTVQYLNDSDVIIFDAKFSEFKEIEEFLNFIVHEYIKDKAVTQPVKEETSAI |
Length | 677 |
Position | Head |
Organism | Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Vanderwaltozyma.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.477 |
Instability index | 36.63 |
Isoelectric point | 5.16 |
Molecular weight | 76609.68 |
Publications | PubMed=17494770
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | activating transcription factor binding GO:0033613 IEA:EnsemblFungi
RNA polymerase II complex recruiting activity GO:0001139 IEA:EnsemblFungi
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IEA:EnsemblFungi
transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi
|
Interaction
Repeat regions
Repeats |
>MDP24756
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 34.25| 10| 152| 449| 458| 1
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449- 458 (19.42/10.94) IELPNE.RIEI
604- 614 (14.84/ 6.80) IELPNKgRLEI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 78.77| 18| 43| 104| 121| 2
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82- 99 (27.43/16.51) DQFIPLILQERGSGFNFA
104- 121 (28.12/17.11) DTLLQEIQNKESSAIDLG
149- 163 (23.23/12.86) NTTNSEITSKNS...DAG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 38.51| 10| 185| 31| 40| 3
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31- 40 (19.69/11.73) SSGSPSLKPT
220- 229 (18.82/10.90) SSLSPFLKKT
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 67.13| 20| 20| 363| 382| 7
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363- 382 (33.62/20.76) SGNDRFIRVRIYTKIESEDD
386- 405 (33.51/20.66) SGESSFDKIFFETNEQSNSE
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|