<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24755

Description Uncharacterized protein
SequenceMSPTKYVLVPPDELHPYINKKDENSNDGNNANNKEMTYPDFDPWRHTKSEDDIMINFVSKGYYTTPKVNFESISARSSLQESLPKLSNHLAEQFSQVLQIREKEINKIPYGNNDPSSSSTQHQLFSLLSGPGFQLPNRVTLTDQRKDQWLQELSSPYASLTKISKFIPHGLKRRQVLEQCCMRQIPLKRAIWLLKCCYSMEWKALSTKHLNSKEINSQLLKEWTENFIFMLEKLVFEMSQYYNDAAKLKVWKREIYYFLKLLGNCYTLELINKDILLHWLVEFISKIEIFEYLPLSLHILSLFWHDISNVNESAPSAQPMFLVTKISDTLLHKYIAVSHNKSMINDEKYIINDVKKNNKIKESILAVIRRLICDLFQRQLLEVFLFPTSSWDLYKPCLYEITNQLNDTPEMVAEVKKKLELISYRNESLKLHYTSRSHTPEDESGTNTSNDESKIEFIKLNCIDFELTEKLDDNPIDFDWASFVDREIQNVSQIVQLILWVIHPSRACRYEGTQLVAKILLLTISSVEGLQEYVVEDIIWSVVFQISKYSEQKRSTFVSLPSLYKLLNMLITYGIVKVPTYIRKLISSGVLYLPESNDKFFHCDALINLKISFLMKSQYNMVLRNVIEYDATFYEKYNFDQLLSVTDELKQKILDSEELDMSEQPYSIKIMMAEWYLGLICGGELEVVNKQTLMKNFNFFCIHFDVFHHFYKWVEFIVYHQLLADIETLETLMNILLRYGKLFSQFINDHILFTKTFILIYTKILKESDNTAYSVTSFMPFWKFFMKNFSYTLNFDEDLRTDLGSVYEEEKAKVERFPKDKELVSLLNDDLHGNISNAKGLVCNFPEVFQTNLRVFFSSEEYSLSKKQARYMLLLIMNASTRDYNKFIAIYLKRKDFKMENLVHLISYKLLTLEQVQNVLGIDFILVLLSYKYEGYDLGFEYYRDHYVRLNYKLLLTACESKLNDHYTLFLEMLIQYGNLWKLYDITSSALLAVFNDSNVDNYKFLRSILFFGVKNYDKDEDIVMTDGISPHVWLDFTNIWLFQSYTKYILLDTLSSGEGLEKAKNFLFSMIEVTNYSCLCAQTFGRINDTDTINILIKIFERKFFDTCLYDKEISNQYLRVIIEVITFLSQQMAINSPSHQDMNVTFIESLRTISKHFAKKDEQELKNIRVKLDSFLKISIIHQTAIFEYVSNLIETNDIKIVNSLLDDLFTLFEKISFDLGLKLMLYEILSSLKSYCQYKSTTESGKGNKSVIVPTKLLELPPFQVSSFLKEEDPDDNEQQLSLGIQTEDDIPYGGRPLSSHPHSVNRCYQKQWFIYSKKTKEHWCRFYNEPYHCINNYQSESSSSFNNSCLNLSLFDARYEKRNPK
Length1369
PositionKinase
OrganismVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Vanderwaltozyma.
Aromaticity0.13
Grand average of hydropathy-0.243
Instability index40.86
Isoelectric point5.93
Molecular weight160931.08
Publications
PubMed=17494770

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24755
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     790.23|     191|     197|     192|     388|       1
---------------------------------------------------------------------------
  160-  336 (256.97/144.38)	...........................LTKISKFIpHGLKRRQVLEqccMRQIPL............................kraiW.LLKCC.YSMEWKALSTKH.....LN.SKE.IN.SQLLKEWTENFIFMLEKLVFEM...S.QYYNDAAKLKVWKREI.YYFLKLLGNC.YTLELINK.D...I...LLHWLVEFISKIEIFEYLPLSLHILSLF..W..HD....ISNVN.......E.................SAPSAQPM.FLVTKISDTLLHKYIA
  341-  535 (222.55/134.39)	KSMINDekYIINDVKKNNKIKESI...LAVIRRLI.CDLFQRQLLE...VFLFPT..............................ssWdLYKPClYEI......TNQ.....LNdTPE.MV.AE.VKKKLELISYRNESLKLHYtsrS.HTPEDESGTNTSNDESkIEFIKL..NC.IDFELTEKlDdnpI...DFDW.ASFVDR.EIQNVSQIVQLIL.....WviHP....SRACR......yE.................GTQLVAKI.LLLTISSVEGLQEYVV
  536-  715 (159.09/83.95)	EDIIWS...VVFQISKYSEQKRSTfvsLPSLYKLL.NMLITYGIVK...V...PTyirklissgvlylpesndkffhcdalinlkisF.LMKSQ.YNMVLRNVIEYD.....AT.FYEkYNfDQLLSVTDELKQKILDSEELDM...SeQPYS....IKIMMAE...WYLGLI..CgGELEVVNK.Q...T...LMKN..........FNFFCIHFDVFHHFykW..VE...........................................................
  716-  889 (151.61/81.39)	........FI...................VYHQLL.ADIETLETLM...NIL.......................................................lrygkLF.SQF.IN.DHIL..FTKTFILIYTKILKES..dN.TAYSVTSFMPFWK.....FFMKNFS...YTLNF.DE.D...LrtdLGSVYEEEKAKVERF...PKDKELVSLL..N..DDlhgnISNAKglvcnfpEvfqtnlrvffsseeyslSKKQARYMlLLIMNASTRDYNKFIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.61|      52|      70|      33|      91|       2
---------------------------------------------------------------------------
   33-   91 (76.89/60.98)	NKeMTYPDFDPwrHTKSEDDIMINFVS.KGYYTTPKVNFESISARSSLQEslpkLSNHLA
  106-  158 (88.72/49.71)	NK.IPYGNNDP..SSSSTQHQLFSLLSgPGFQLPNRVTLTDQRKDQWLQE....LSSPYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     148.96|      38|     248|     940|     989|       3
---------------------------------------------------------------------------
  908-  938 (39.24/11.51)	YKLLtLEQVQNVLGIDFILVL.LSYKYEG....YDL...
  952-  989 (68.65/48.36)	YKLL.LTACESKLNDHYTLFLEMLIQYGNLWKLYDITSS
 1205- 1234 (41.07/15.02)	.........NSLLDDLFTLFEKISFDLGLKLMLYEILSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.44|      24|      71|     995|    1018|       5
---------------------------------------------------------------------------
  995- 1018 (43.46/31.03)	FNDSNVDNYKFLRSIL...FFGVKNYD
 1069- 1086 (30.37/19.04)	FSMIEVTNYSCLCA.........QTFG
 1088- 1112 (32.61/21.09)	INDT..DTINILIKIFerkFFDTCLYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.79|      15|     191|    1044|    1060|       6
---------------------------------------------------------------------------
 1044- 1060 (22.75/17.86)	QSYTKYilLDTLSSGEG
 1236- 1250 (29.04/16.48)	KSYCQY..KSTTESGKG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24755 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DELHPYINKKDENSNDGNNANNKEMTYPDFDP
12
43










Molecular Recognition Features






MoRF SequenceStartStop




1) MSPTKYVLVPPDELHPYIN
1
19