<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24735

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAPEVPSNKINLSMLIDFLLQKTYHELTVLSELLPRKPDIERKIEIVQFASRTRQQFVRLLALVKWAGGAKGVAKCQAISTFLDQQSMVFVDTADMLARMARETLVQARLPTFCLPAAVDVLTTGTYQRLPTCIRDKIVPPDPLSLSEKNKTLQRLNEVIQHRLVLARIPPQMASLKIADGCVTFHVDNEFEVSLTLMGDDPALPWRLLSINILVEDIETGDGKPLVHQMQYIFRRYFFNYCPDSFCLSLQLQVLHFQAKQLIHERWHENVKIESYAVGKTLTLSYWRTSPSQHSQRQVQGHAMTISYQSDQNPGYLSISHQPPLPVNSKEDCLDKVMPSNLCIERLLMQSVRLQSITNLKNLLSLLSEHINSKEPPKLLPGKYCDAVCIMHMTSVEYFFLNLLSLLSEHINSKVLLDRCMPSLAIQTCKQATPSEVLIIAVDTRTGNFKVSLGDGEENLICTDMEKALNADPQKFPTLLGDARCQLHLHKCRRSVSLLPIMPLSYLPLTEVSRGKLCMLSKHHMFLKFKNHPNFFLVVEVSSAAESDKVCVKYSLLRTKSVDVDNLEPEVSRRDSTVKQEDKGGASMPAGNVQPLFLAVKHIVEVSPERMTDFPGTMIKGFSDGKMESVPVKRKHDYCEEERAKRIKTTTELYKKCTNTSSFQAELSHIVCSCDGRIPFVSLCEDLRRHGVVHSGVTSEAAVGLCVEIPHLPTPQGCKEDLVTTLHSNMISCTLRFSGQEYAHCDFEMYFAYPPFLTDSEKLQAKRIALKYAYTQPEPGASEPGVVQKFLDDWCCICKLYAHALDLDMCIKDNQSHVRHMFRVESYTYRQLTLQYEPDRQNMVTVEWSVAESKFLLSFSHSGSSDTDNPHRIMAEQLQKDFNKRLNLPYLMQILHETWKPLTALGRLPTRPTLGVITRPLMPYRTFAVIPQSPTSVHLLYRPTHALEIHFKAKNLLSIRDASISSVDPTKPMGMLQTITNLKLFLQIYVDDIAKAGGIPSRRASGADDEGPPSPLNTEMEPPIDVQFTSPQPMPGRNSSPIVPRASPQPPTARPYGTSPGTSAMSPSNPYSSPSPITHYMVNSPAPYHPMASPAMSPGGQVPKYRQSGAVAVTSKLPTTPPRPLIARGWALTTPTILSHAAFTKLCSPVMSVGRHGNVSPLEMFMGSMFLKKHFSRAAASDDLVRSRIDSLSYSDDLVRSRLESLSYSDDLVRSRLDSLSYSYDLVRSRLDSLSYSDDLVRSRLDSLSYSDDLVRSRLDALSYSDDLVRSRLDSLSYSDDLVRSRLDALSYSDDLVRSRLDSLSYSDDLVRSRLDSLSYSDDLVRSRLDSLSYSDDLVRSRLDSLSYSDDLVRSRLDSLSYSDDLVRSCLDSLSYSDDLSDDLVRSRLDALSYSDDLVRSRLDSLSYSDDLVRSRLDSLSYSDDLVRSRLDALSYSDDLITIVKADASRILFKVNNNSPQCNLQCVLSMDTKTFTSLRLNLSPIQPQDTMWTHDVLRTLERFFDTRVACPPYKANSMTSFVRILTAAPKILLDLIRLIKLEMIELTRQGVPGGAGTRDESSVFVPLLYHPQTNTTQQAEMTREPGTQSSSSAAISAFLRRWNESVASKTTECTLFLAVQELAKNLVLPTSPSLNDH
Length1638
PositionTail
OrganismNematostella vectensis (Starlet sea anemone)
KingdomMetazoa
LineageEukaryota> Metazoa> Cnidaria> Anthozoa> Hexacorallia> Actiniaria> Edwardsiidae> Nematostella.
Aromaticity0.07
Grand average of hydropathy-0.255
Instability index54.59
Isoelectric point6.84
Molecular weight184025.66
Publications
PubMed=17615350

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24735
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     516.25|      39|      39|    1251|    1289|       1
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 1186- 1227 (83.72/51.07)	VRSRIDSLSYSDDLVRSRLEslsY....SDDLVRSRLDSLSYSYDL
 1228- 1269 (87.61/53.82)	VRSRLDSLSYSDDLVRSRLDslsY....SDDLVRSRLDALSYSDDL
 1270- 1311 (87.78/53.93)	VRSRLDSLSYSDDLVRSRLDalsY....SDDLVRSRLDSLSYSDDL
 1312- 1353 (87.78/53.93)	VRSRLDSLSYSDDLVRSRLDslsY....SDDLVRSRLDSLSYSDDL
 1354- 1399 (81.74/49.67)	VRSRLDSLSYSDDLVRSCLDslsYsddlSDDLVRSRLDALSYSDDL
 1400- 1441 (87.61/53.82)	VRSRLDSLSYSDDLVRSRLDslsY....SDDLVRSRLDALSYSDDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      61.26|      11|      17|    1042|    1052|       2
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 1042- 1052 (24.38/12.29)	PIVPRASPQPP
 1061- 1071 (19.29/ 7.92)	PGTSAMSPSNP
 1077- 1087 (17.58/ 6.46)	PITHYMVNSPA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     115.68|      28|      32|     673|     700|       3
---------------------------------------------------------------------------
  625-  660 (23.10/10.60)	...DGKMESVPVkrkhdyC.EEERAKRIkttteLYKKCTN
  673-  700 (51.30/33.91)	CSCDGRIPFVSL......C.EDLRRHGV.....VHSGVTS
  707-  733 (41.28/25.63)	CVEIPHLPTPQG......CkEDL..VTT.....LHSNMIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.62|      37|      39|     337|     375|       4
---------------------------------------------------------------------------
  328-  358 (29.63/12.33)	...........VNSKedcldKVMPS...NLCIERLLMQSVRLQSI
  361-  400 (62.55/37.45)	LKNLLSLLSEHINSK..eppKLLPG...KYCDAVCIMHMTSVEYF
  401-  430 (26.44/ 7.49)	FLNLLSLLSEHINSK.vlldRCMPSlaiQTC..............
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.35|      10|      57|    1089|    1104|       5
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 1089- 1098 (20.25/ 7.99)	YHPMASPAMS
 1144- 1153 (17.10/ 6.71)	FTKLCSPVMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     126.32|      31|      32|     906|     936|       7
---------------------------------------------------------------------------
  906-  928 (33.44/16.02)	............LGRL....PTRP.TLGVITR.PLMPYRTF
  929-  963 (33.19/15.84)	AVIPQSPTsvhlLYR.....PTHAlEIHFKAK.NLLSIRDA
  964-  986 (23.08/ 8.70)	SI..............ssvdPTKP..MGML.Q.TITNLKLF
  989- 1019 (36.61/18.26)	IYVDDIAK....AGGI....PSRR.ASGADDEgPPSPLNT.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.82|      20|      29|     442|     461|      10
---------------------------------------------------------------------------
  442-  461 (33.40/20.46)	AVDTRTGNFKVSLGDGEENL
  469-  488 (35.43/22.16)	ALNADPQKFPTLLGDARCQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.19|      22|      28|     232|     253|      11
---------------------------------------------------------------------------
  232-  253 (42.61/28.78)	QYIFRRYFFNYCPDSFCLSLQL
  262-  283 (38.58/25.32)	QLIHERWHENVKIESYAVGKTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.68|      21|      28|     541|     567|      12
---------------------------------------------------------------------------
  512-  535 (32.60/18.40)	EVSRG....KLCMlsKHHMfLKFK..NHPN
  541-  567 (26.08/29.24)	EVSSAaesdKVCV..KYSL.LRTKsvDVDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.31|      15|      36|     757|     771|      13
---------------------------------------------------------------------------
  757-  771 (24.88/15.19)	FLTD...SEKLQAKRIAL
  791-  808 (22.42/12.95)	FLDDwccICKLYAHALDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     242.91|      79|     621|     812|     903|      16
---------------------------------------------------------------------------
  812-  903 (120.46/119.49)	IKDNQShvRHMFRVESYTyRQLTLQ..YEPDRQNMVTVEwsvaeskflLSFSHSGSSDTDNPHRIMaEQLQKDFNKRLNL.PY.......LMQILHETWKPL
 1445- 1533 (122.45/85.31)	VKADAS..RILFKVNNNS.PQCNLQcvLSMDTKTFTSLR.........LNLSPIQPQDTMWTHDVL.RTLERFFDTRVACpPYkansmtsFVRILTAAPKIL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24735 with Med14 domain of Kingdom Metazoa
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