<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24721

Description Predicted protein
SequenceMLSALGGENQEAEAGARLTCHLLLRLLDESTDVMSHDHSSASKYSFKSSPDHNLLAAAHEHIVVDAVLAVLKAMLKLSEAGRNNGLGSHGTESSRDDGFRTWFSAKLDDFMDSSGSTGDIFPPPLASSRSAMETSNTSAFAGFTLQVICSQEWVRERCLHDLEKLCSPELLLDPALTVSQARKLLHLICYPAGVPTSLGGPSILPGGETETVKEAASRILQNLDQWSLRKSWLELQLMIKQACKDAQMIAKHSPKEGYTELVYQDRVPLYSFIRTGLIYVLVNRVPLYSFIRTGLINVLVNRVPIYPFIRTGLIRGLVNRVSLYSFIRTGLINVLVNRVPIYPFIRTGLIHGLVNRVSIYSFIRTGLINVLVNRVPIYPFIRTGLINGLVNRVSIYSFIRTGLINVLVNRVPIYPFIRTGLIRGLVNRVSLYSFIWTGLIDVLVNRVPLYPFITTGLILSLLTGFHCTRYRTGLISGLVNRVSLYSFIWTGLINVLVNRVPIYSFIRTGLISGLVNRVSMYSFIRTGLINVLVNRVPIYPFIRTGLIRGLVNRVSLYSFIWTGLTDVLVKGFPLYHCCITCHLQQEVGPLLDAIATGAMSVFVQRHDTSPLATAHNSPKSSIIKGPEWLVAPLISKLSNSVQGRLLKTAGEPTLVHIQKFYRLAWHPSLPISMHFDLWSILDPSRSTLVHTQPFLSLVLACLKGQEGQREGLLLSISRQISQLLQAPVEARKLLHLICYPAGVPTSLGGPSILPGGETETVKEAASRILQNLDQWSLRKSWLELQLMIKQACKDAQIIAKHSPKEGPLYSFIRTDLINVLVNRVPIYPFTRTGLICGLVNRVPLYSFIRTGLINVLVNRVPIYPFTRTGLIRGLVNRVSLYSFIWTGLINVLVNRVPIYPFTRTGLIRGLVNRVSLYSFIWTGLINVLVNRVPIYPFTRTGLIRGLVNRVSLYSFIRTGLINVLVNRVPIYPFTRTGLIRGLVNRVSLYSFIRTGLINVLVNRVPIYPFIRTGLIRGLVNRVSLYSFIWTGLINVLVNRVPIYPFTRTGLIRGLVNRVSLYSFIRIGLIYVLVNRVPLYSFIRTGLINVLVNRERCPADLKSKEVLQEALHLRISLERCPADLKSKEVLQEALHLRISLVGAMFDTIQRSVALSSDWASVLFQLVSSGTITTESLPSKKELLTNVLDMVCVLISVVTNTDGLSGPAAEESRKAAGALFKKLKRELAGKSPMDIIQCKQLLPLPSLSHNVYTVEPSTETSPAQTDMQGLQINGKQKISAWELMEGQKNPSPFAWAWFGAVRIERKPLRYEQEFRKLMHHNHARRKPASYFMNTNHEDSEDDEEDEKMEAEEGGDKSSQPATPQTPAEAKGQLKSIGTPGTPSSTLGQATPSSQPDQAVATPDEKPKPKARRPAVKRQRSQGPSMAQQRKLQQQLQKQYLQPQQAGMLYGQQGQQYLPQQGVAGQMAPGAQPRRPGQTTAMLAQLLQQRQQQQQQPQQAQQAIYMQQQLQQQTQQLQQQTQQLRHLPTPQQTMQPGQAVTLRPEQPYGFSQAQRPTNLQIPARPQGPARASTPNTPTSMGLPTSAGSMNPPSVYGTQAYQGGNQGLTHPMQQQQQQQFTLQQQRPMQPQAPQGTAILQHPLQAGTQQQQGGQMNQGIPMSQMSQGMQLPVMNQGGQISQMSQSGAMTQINQGQISQMSQGGQLNQMNQGGQMSQMNQGMQMPQMSQGGQMPQMNQGGQMTQMSQGGAMTQMTQGQAGQISQGGQIPQMNQGGQMPQMNQGGQMTQMSQGGAMTQMTQGQAGQISQGGQISQSIYQQQQMTNRVNSLNANQQLLVKQRLQMVLKQQQQQQQQQQQQQLPQEIMRHLRQFQGGSQDIGVQHQFTTGQDMNQLQRQMSAPSDVGMQRQVSQDMASFQRQLSAPGGVQDLTQQQQQQQQQFNNSQFQPGQF
Length1945
PositionKinase
OrganismNematostella vectensis (Starlet sea anemone)
KingdomMetazoa
LineageEukaryota> Metazoa> Cnidaria> Anthozoa> Hexacorallia> Actiniaria> Edwardsiidae> Nematostella.
Aromaticity0.07
Grand average of hydropathy-0.206
Instability index47.43
Isoelectric point10.02
Molecular weight216570.46
Publications
PubMed=17615350

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24721
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            32|    1127.83|      14|      16|     858|     871|       1
---------------------------------------------------------------------------
  265-  278 (33.52/16.48)	D....RVPLYSFIRTGLI
  283-  296 (36.80/18.75)	N....RVPLYSFIRTGLI
  301-  314 (37.59/19.31)	N....RVPIYPFIRTGLI
  319-  332 (35.31/17.72)	N....RVSLYSFIRTGLI
  337-  350 (37.59/19.31)	N....RVPIYPFIRTGLI
  355-  368 (35.41/17.79)	N....RVSIYSFIRTGLI
  373-  386 (37.59/19.31)	N....RVPIYPFIRTGLI
  391-  404 (35.41/17.79)	N....RVSIYSFIRTGLI
  409-  422 (37.59/19.31)	N....RVPIYPFIRTGLI
  427-  440 (35.78/18.05)	N....RVSLYSFIWTGLI
  445-  458 (34.33/17.04)	N....RVPLYPFITTGLI
  480-  493 (35.78/18.05)	N....RVSLYSFIWTGLI
  498-  511 (36.90/18.83)	N....RVPIYSFIRTGLI
  516-  529 (33.77/16.65)	N....RVSMYSFIRTGLI
  534-  547 (37.59/19.31)	N....RVPIYPFIRTGLI
  552-  565 (32.76/15.95)	N....RVSLYSFIWTGLT
  807-  817 (20.14/ 7.20)	.......PLYSFIRTDLI
  822-  835 (36.44/18.50)	N....RVPIYPFTRTGLI
  840-  853 (36.80/18.75)	N....RVPLYSFIRTGLI
  858-  871 (36.44/18.50)	N....RVPIYPFTRTGLI
  876-  889 (35.78/18.05)	N....RVSLYSFIWTGLI
  894-  907 (36.44/18.50)	N....RVPIYPFTRTGLI
  912-  925 (35.78/18.05)	N....RVSLYSFIWTGLI
  930-  943 (36.44/18.50)	N....RVPIYPFTRTGLI
  948-  961 (35.31/17.72)	N....RVSLYSFIRTGLI
  966-  979 (36.44/18.50)	N....RVPIYPFTRTGLI
  984-  997 (35.31/17.72)	N....RVSLYSFIRTGLI
 1002- 1015 (37.59/19.31)	N....RVPIYPFIRTGLI
 1020- 1033 (35.78/18.05)	N....RVSLYSFIWTGLI
 1034- 1051 (30.84/14.62)	NvlvnRVPIYPFTRTGLI
 1056- 1069 (31.75/15.25)	N....RVSLYSFIRIGLI
 1074- 1087 (36.80/18.75)	N....RVPLYSFIRTGLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            13|     564.21|      34|      34|    1721|    1754|       2
---------------------------------------------------------------------------
 1398- 1431 (31.76/ 7.65)	AT..P...DEKPKPK.ARRPAVK........R.QRSQGPSMAQQRKL.QQ
 1432- 1461 (37.77/10.48)	QL..Q...KQYLQPQ...QAGML...........YGQQGQQYLPQQG.VA
 1463- 1491 (39.20/11.16)	QM..A...PGAQ....PRRPGQT........T.AML..AQLLQQRQQ.QQ
 1582- 1613 (34.66/ 9.02)	....S...AGSMNPP.SVYGTQA........Y.QGGNQGLTHPMQQQ.QQ
 1615- 1657 (34.03/ 8.72)	QF..TlqqQRPMQPQ.APQGTAIlqhplqagT.QQQQGG...QMNQGiPM
 1659- 1692 (60.85/21.39)	QM..S...QGMQLPV.MNQGGQI........S.QMSQSGAMTQINQG.QI
 1694- 1719 (52.64/17.51)	QM..S...QGGQLNQ.MNQGGQM........S.QMNQGM.........QM
 1721- 1754 (74.12/27.66)	QM..S...QGGQMPQ.MNQGGQM........T.QMSQGGAMTQMTQG.QA
 1769- 1798 (59.29/20.65)	.........GGQMPQ.MNQGGQM........T.QMSQGGAMTQMTQG.QA
 1800- 1835 (31.70/ 7.62)	QI..S...QGGQISQsIYQQQQM........TnRVNSLNANQQLLVK.QR
 1837- 1868 (36.08/ 9.69)	QMvlK...QQQQQQQ.QQQQQQL........P.QE....IMRHLRQF.QG
 1878- 1909 (38.85/10.99)	QF..T...TGQDMNQ.LQR..QM........S.APSDVGMQRQVSQD.MA
 1914- 1944 (33.26/ 8.36)	QL..S...APGGVQD.LTQ..QQ........Q.QQQQQFNNSQFQPG.Q.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     641.84|     195|     548|      18|     257|       3
---------------------------------------------------------------------------
   18-  237 (313.43/228.04)	LTCHLLLR...LLDE.STDVMShdhssaskySFKSSPDHNLLAAAHE....HIVVDAVLAVLKAMLKLSEA..GRnnGLGSHG..TESSRDDGFR.TWFsAKLDDFMDSSgsTGDIFPPplasSRSAMetSNTSAFAGFTLQVICSQEWVRERCLHDLEKLCSpELLLDPaLtvsQARKLLHLICYPAGVPTSLGGPSILPGGETETVKEAASRILQNLDQWSLRKSWLELQL
  579-  786 (328.41/181.84)	ITCHLQQEvgpLLDAiATGAMS.........VFVQRHDTSPLATAHNspksSIIKGPEWLVAPLISKLSNSvqGR..LLKTAGepTLVHIQKFYRlAWH.PSLPISMHFD..LWSILDP....SRSTL..VHTQPFLSLVLACLKGQEGQREGLLLSISRQIS.QLLQAP.V...EARKLLHLICYPAGVPTSLGGPSILPGGETETVKEAASRILQNLDQWSLRKSWLELQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     178.85|      32|      33|    1513|    1544|       4
---------------------------------------------------------------------------
 1235- 1260 (38.38/15.54)	.QCK.QL..LPLP..SLSH..NVYTVEPS.TE....TSP
 1365- 1396 (24.35/ 6.67)	AEAKgQLKSIGTPGTPSSTlGQA.T..PSsQP...dQA.
 1492- 1515 (28.77/ 9.47)	QQPQ.QAQQAIYMQQQLQQ..Q............tqQLQ
 1516- 1551 (54.60/25.79)	QQTQ.QLRHLPTPQQTMQP.GQAVTLRPE.QPygfsQAQ
 1552- 1574 (32.74/11.97)	RPT.....NLQIPARPQGP.ARAST..PN.TP.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.35|      16|      33|    1156|    1174|       6
---------------------------------------------------------------------------
 1167- 1194 (17.98/16.29)	SGTITTESlpskkelltnvlDMVCVLIS
 1203- 1219 (21.37/ 9.20)	SGPAAEES...........rKAAGALFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.59|      20|      20|    1095|    1114|      16
---------------------------------------------------------------------------
 1095- 1114 (41.79/37.20)	RCPADLKSKEVLQEALHLRI
 1118- 1137 (41.79/37.20)	RCPADLKSKEVLQEALHLRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.55|      20|     547|     238|     257|      22
---------------------------------------------------------------------------
  238-  257 (43.61/28.82)	MIKQACKDAQMIAKHSPKEG
  787-  806 (42.94/28.26)	MIKQACKDAQIIAKHSPKEG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24721 with Med12 domain of Kingdom Metazoa
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