<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24718
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MADRESIRGRNTKERVNRLLDDYERLTKQLFESFSSPYQGTRQDVSTGDSTQISYVAVKMSYVAVKVSYVAVKVSYVAVKVSYVAVKVSYVAVKVSYVAVKVSYVAVKVSYVAVKVSYIAVKVSYVAVKVSYVAVKVSYVAVNVSYVAVKISYVAVKMSYVAVKVSYGAVKVSYVAVKVSYVGEHFIGGKPNQAYPVPNINLAVEIPGGPGANREAEVLEKLTSKDKELQAAVVQAKEQQKRQQDIESLKLHIAKKDEKILALEVQLKEAEQILSQALFQAKKKLTAIEKANKGSVSSEELIKYAHQISSSNAVEAPTTWMAGDPRRPYPLDIEMRSGLLGRLGEGVAMETEIPTSTVGVAETSAVTAPVNGVVDGVANGPSASSLSWQSSLHAIGIPSTTEQTSIGNDVTMGAANGRNELTTEEVEFMSSSSCSSSSDSP |
Length | 441 |
Position | Middle |
Organism | Nematostella vectensis (Starlet sea anemone) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Cnidaria> Anthozoa> Hexacorallia> Actiniaria>
Edwardsiidae> Nematostella.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.039 |
Instability index | 38.72 |
Isoelectric point | 9.00 |
Molecular weight | 47442.59 |
Publications | PubMed=17615350
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP24718
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
6| 222.43| 18| 18| 66| 83| 1
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66- 83 (41.08/19.28) KVSYVAVKVSYVAVKVSY
87- 104 (41.08/19.28) KVSYVAVKVSYVAVKVSY
108- 125 (39.78/18.49) KVSYVAVKVSYIAVKVSY
129- 146 (40.05/18.65) KVSYVAVKVSYVAVNVSY
150- 167 (39.45/18.29) KISYVAVKMSYVAVKVSY
171- 182 (20.99/ 7.05) KVSYVAVKVSYV......
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 79.99| 23| 40| 358| 380| 2
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358- 380 (38.88/23.23) VGVAETSAVTAPVNGVVDGVANG
395- 417 (41.11/24.94) IGIPSTTEQTSIGNDVTMGAANG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 79.21| 28| 40| 212| 243| 3
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212- 239 (42.04/38.44) ANREAEVLE...KLTSKDKELQAAVVQAKEQ
254- 284 (37.17/22.18) AKKDEKILAlevQLKEAEQILSQALFQAKKK
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