Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MVSTTSTPTSSTHTTTTSPFYLLRNEPPTPTDINGSSNLLVQNGLEQSYQKFCGKKVKENLSAFLPHLPGYIDEKGTPENSLRSVIDKPPIGGKELLPLPSHALSGFRLNPGPIPEQFRFMTQQPTKKKHKHKKHKSQDGERAKSLVDTVIATGLPGQPSPADSKLDGGHERKHKKQKKHDDGERKKKKKDKKKKKRHTPDPVGPGDGSQSGRV |
Length | 214 |
Position | Head |
Organism | Nematostella vectensis (Starlet sea anemone) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Cnidaria> Anthozoa> Hexacorallia> Actiniaria> Edwardsiidae> Nematostella. |
Aromaticity | 0.04 |
Grand average of hydropathy | -1.151 |
Instability index | 45.52 |
Isoelectric point | 9.95 |
Molecular weight | 23603.52 |
Publications | PubMed=17615350 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IBA:GO_Central |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro transcription factor binding GO:0008134 IBA:GO_Central |
GO - Biological Process | positive regulation of transcription by RNA polymerase II GO:0045944 IBA:GO_Central |
Binary Interactions |
Repeats | >MDP24712 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 167.68| 42| 42| 127| 168| 1 --------------------------------------------------------------------------- 75- 111 (34.61/12.02) ..........KGTPENSLRSVIDKPPIGGkelLP.LP.SHALSgfRLNP 127- 168 (73.50/32.99) KKKHK.HKKHKSQDGERAKSLVDTVIATG...LPGQP.SPADS..KLDG 171- 212 (59.57/25.48) ERKHKkQKKH..DDGERKKKKKDKKKKKR...HTPDPvGPGDG..SQSG --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KKKHKHKKHK 2) KLDGGHERKHKKQKKHDDGERKKKKKDKKKKKRHTPDPVGP 3) PFYLLR | 127 165 19 | 136 205 24 |
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