<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24710

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMTSLPNPIPISLRPAPTPAKSSIPLPLLIARINAERGGFRNLSEDSLRQEIAEAELGEDDEENESSSEDGEAEEEPDRMKELLTARDEILGQLDAAMISLDFISLLLSKDAPVQASLSISPSLRELTGTGTLGADKIADSRVTEEQKKENKKIAKGWKASNLSKTVDAILASATRLEKEIDAETKYWEQVLAVSESGWAVCRLPQEKHTLGVRFGFAEASPTFRNRSLGALRRNPDGSIYLDQGITSPEPQSLRVLVETNGVTTGETILPKAVPQDAPIQDLILQARNTIFTSELWQEMIREVRTLASHGLQSDSKTNTITFPLSPTKKILIELQTLPTDPFRPVLGPRPDSYLANGIYLTLHLLLSLSHRRHHRIRTNPPPPISGQPRPNNPFPILRSLLTRFAHETVISSLHSLLTPLCTALTSACLSTPPTYIITPGTSSSFQNLSTPERILTTLTNHLEFLTTITFPFPLSSPPHSSIPSSFSHTTPLTPVPSILQIRTLTITQNYSRPVYYLRITPDTSPLLQICPPPPAVAEWDYVKDYILWAMGCWLAYIFSSPFTKEEEGWKVTTQANILRKIFSGLNDEGGVKQMSFEVSSIPILGPEVPGRVGEKGKEKIRISVRWEWTTGIDQEWKERRDLKQGEGAYDWYSGVGAIGAGELEEVVRKIGDVVEEAGRGKL
Length682
PositionHead
OrganismSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Sclerotiniaceae> Sclerotinia.
Aromaticity0.06
Grand average of hydropathy-0.308
Instability index55.04
Isoelectric point5.61
Molecular weight75434.93
Publications
PubMed=21876677

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24710
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.66|      20|      72|     245|     264|       1
---------------------------------------------------------------------------
  245-  264 (32.51/15.26)	ITSPEP.QSLRVLVETNGVTT
  273-  292 (25.82/10.76)	VPQDAPiQDL.ILQARNTIFT
  320-  339 (29.32/13.12)	ITFPLS.PTKKILIELQTLPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     146.45|      34|      37|     433|     469|       2
---------------------------------------------------------------------------
  381-  422 (37.03/12.40)	PPPISgQPRPN...NPFPILrslltrfahetviSSLHSLLTPLC......T
  433-  466 (59.86/26.85)	PTYII.TPGTS...SSFQNL.............STPERILTTLTNHLEFLT
  471-  503 (49.56/24.45)	PFPLS.SPPHSsipSSFSH..............TTP...LTPVPSILQIRT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.12|      26|      96|       1|      28|       4
---------------------------------------------------------------------------
    1-   28 (39.99/24.75)	MTSLpNPIPISL.RPAPTPAKSSIPlPLL
   97-  123 (40.13/17.25)	MISL.DFISLLLsKDAPVQASLSIS.PSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.90|      24|     118|     221|     244|       6
---------------------------------------------------------------------------
  221-  244 (44.91/34.05)	PTFRNRSLGALRRNPDGSIYLDQG
  341-  357 (33.66/23.27)	P.FR.PVLG.....PRPDSYLANG
  366-  380 (18.33/ 8.56)	LSLSHRRHHRIRTNP.........
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24710 with Med17 domain of Kingdom Fungi
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