<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24709

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDSGSRNGSHTNHDRDRHSNGTNGEVKASEKGRDKNQALSEPQQNMTPISPAVPNGMNGNLTDGPARQQNAGEDPIPKDILDRIHDLPPEVEHITFNFLSLTELLNRLAQSSHNELRQEITKLASMPTPQSAINGSSSHITKEDDTSNDNVNKKVSLLDFAQTQHSRWVKQLVLLDWSRKADQVSKIIDLNVHLIHKRGLYNIILAHIGDVKKKLCDIDSPSPDLKTAVEVLSTGKANWMPDLGYIPPPPMTSKEILKSLEKLNTLLSIRLNLHERQAVELSRSTWIDGVKVEPLHRALCIQYWLDRYKKNGPRSWIIIGVHSGRRKDGYHDPRTTSRLFIRWFRDSKEVKDMDILFDTVNISAEQLLKTVIAMHVNHILRSTHSKLAAEPIFANREASLSLHTSKTEPKESVLGVQLTEKQHLSITIEPVTGIFIFSPASRIITSSQNKLNSLDRDPATDAHYNIENLRCLAISEELTILGTSVGWRRADNPGISREDLKRKIPKDTKQITWFRRPGWQEDWLVAVTLGMTGESWWLFQTSKQPTGVKVLTSIHIPIKAVSPTPSYVFMSTLHIFAGGLISQYTNLKALHDRRIHHTIRQTGLPSPVKLPSIWIHISELFSARAKPAAQKTWAKDFLKLSFQGLEPFSALSSLPPQSPTDDPQATSHKLEQKAVLVTVARMAVPIPALSVLNEKIDKDIAFKAQTGEIAFRLRSQVGKSIIPSLTERLFQVERLISCTAVLRKHEKFIKCDTISLQEITFSYGMPPPAETGSDMGADKAKARSYKAVVSLGLVEGKMKLTLETGNPHIRVLDALDKVLNIPKGGFDAVTTLLPQTLSCLRAFETIEDAWAPLYDKGEVFIFVRAFEWFNLRYILKSSTPDTPPRKVSFEIKMCHRKQKPWWLVRRTEKTERAGKEEVLPDDGIDACLKSVWDSPGDDDWKGMRTSAVGRNRGIETCLEKVDAVIRNLSPEDLSLQPSQQSQSRMQAQAIGSQGQQSSHLQQQRQSQLPTPANSQNHSQSHGSSQGHQRMPAPNMNMNLNINQNMLKRKPSSQGINPRTAKREVVEID
Length1068
PositionTail
OrganismSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Sclerotiniaceae> Sclerotinia.
Aromaticity0.06
Grand average of hydropathy-0.488
Instability index55.89
Isoelectric point9.31
Molecular weight119917.53
Publications
PubMed=21876677

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP24709
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.78|      33|      37|      20|      53|       1
---------------------------------------------------------------------------
   20-   53 (52.98/37.75)	NGTNGEVkASEKGRDKNQALSE.PQQNMTPI...SPAV
   55-   91 (50.80/31.44)	NGMNGNL.TDGPARQQNAGEDPiPKDILDRIhdlPPEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.82|      28|      29|     999|    1026|       2
---------------------------------------------------------------------------
  112-  139 (25.39/12.30)	SHneLRQEitKLASMPTPQ.S.....AINGSSSH....
  998- 1025 (53.98/34.98)	SH..LQQQ..RQSQLPTPA.N.....SQNHSQSHGSSQ
 1026- 1053 (29.45/15.52)	GH..........QRMPAPNmNmnlniNQNMLKRKPSSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.70|      14|      29|     918|     931|       3
---------------------------------------------------------------------------
  918-  931 (25.36/19.55)	VLPDDGIDACLKSV
  948-  961 (25.34/19.53)	VGRNRGIETCLEKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.18|      25|      29|     261|     287|       4
---------------------------------------------------------------------------
  261-  287 (32.99/30.28)	EKLNTLLSIRLNLhERQAVELSRStWI
  293-  317 (50.19/33.75)	EPLHRALCIQYWL.DRYKKNGPRS.WI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.76|      36|      38|     544|     580|       5
---------------------------------------------------------------------------
  544-  580 (59.70/42.07)	QPTGVKVL..TSIHIPIKAvSPTPSYVFMSTLHIFAGGL
  583-  620 (60.06/37.89)	QYTNLKALhdRRIHHTIRQ.TGLPSPVKLPSIWIHISEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.92|      26|     167|     318|     345|       7
---------------------------------------------------------------------------
  318-  345 (42.76/36.07)	IIGVHSG.RRKD....GYHD.....PRTTsRLfIRWFR
  480-  515 (32.16/17.96)	ILGTSVGwRRADnpgiSREDlkrkiPKDT.KQ.ITWFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.88|      16|      39|     384|     399|      14
---------------------------------------------------------------------------
  384-  399 (27.92/17.14)	HSKLAAEP...IFANREAS
  423-  441 (23.95/13.72)	HLSITIEPvtgIFIFSPAS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24709 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ELRQEITKLASMPTPQSAINGSSSHITKEDDTSN
2) LSPEDLSLQPSQQSQSRMQAQAIGSQGQQSSHLQQQRQSQLPTPANSQNHSQSHGSSQGHQRMPAPNMNMNLNINQNMLKRKPSSQGINPRTAKREVVEID
3) MDSGSRNGSHTNHDRDRHSNGTNGEVKASEKGRDKNQALSEPQQNMTPISPAVPNGMNGNLTDGPARQQNAGEDPIPKDILDRIHDL
115
968
1
148
1068
87










Molecular Recognition Features






MoRF SequenceStartStop




1) INQNMLKRKP
1041
1050