<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24707
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MALQQEDLKALEQTRQRLLHLTSNIASLKTGFQRGAPLPEYSSVMTSSSILSTNIQSVIDHLAANSEILSRIVAFPSTNFPGRTQEGLLLQLLRKKLEPQVETWVEEGRNLQIDGAGEGANQGDLEETWKWAAEWIGPRIREYALNEAGDEYTAEERESGVENVNTGLKDEEESDEEDEEGDEDDEVMGGMDRSAEKKKAPEKIIMRKDGRVRSKEEILRFAASGVI |
Length | 227 |
Position | Head |
Organism | Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes>
Helotiales> Sclerotiniaceae> Sclerotinia.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.712 |
Instability index | 52.39 |
Isoelectric point | 4.58 |
Molecular weight | 25375.84 |
Publications | PubMed=21876677
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central
mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA:GO_Central
transcription coregulator activity GO:0003712 IBA:GO_Central
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP24707
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 61.77| 19| 22| 155| 176| 1
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155- 173 (29.78/23.36) EERESGVENVNTGLKDEEE
178- 196 (31.99/16.11) DEEGDEDDEVMGGMDRSAE
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