<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24701

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEDVENMDVDMDDLFGDGAGLSLPSRPPPSKELHQRIDELRGSGCCQGIAWSKWGSIASIAPNGNGLELRNLRCHPTDGTWGLSKPTLIPQLTNNLDGGPLKHLSWSPTGSELAVIDSAGRHGPAVKEASGFRYDASQAPILGPSHPIPSKSAFLYVTSNGSLRLLWQQGNNKWFESHTELESIVSSDDLITHAAICAERTPSLLIALATGSKQLRIIRAGIDWGMPQTQEKVNQMTLSLNASLRIKPLTVTSWMHDVPGDTLNPSHLESSMVQLSHLKFLSPCIDSKNHMTPPIVMAVRSYLPGPTSHYNQEVYSTVDRWEFRERNQQPVHSAFEHLSSRKGTDGPQSTKPVYTAQLKKLESFTVNKIVVAMQTIYIGRVICFAYSDSSVDYRDRITMNETFNDGDLDRVSHLSQIGFSYTEDEPCLQVVLSPSTCSLAQITNDGKVKWKQLDYHLGEIGSSMEDPRYAAMITALSTSCSTSVMIFINYDDIIATAHSFAKTKDNLAYDWLNELAKILKITVDYSEEAHYDVLIRNTTIQLCLSIQNSLGFRGDFNPRKFAGKFSWLVLQLRNIVVLVTMAANMKVPGPTHDKTSTPLDDPEVISALAGSVRWVLDLMAWIIDTLLDLPSSLPGELSLTDPAKLSLPDLLAHLHTQNNVTLHLLLSSPTRGFLTAICRRLQHLDYVARKAIATNTNAQNQPGGQGQQSISPALRSSYVQIAQLTSNCIVRIKTFETLLSSLTLSVKSAYASHKPPLPVNNSSGPSRNGLEMKMLFGGEIPTAFKPVIIDLFKGVQDNKKSNESNTAPDNAGTGHLSAVRLEIEPSDLWFADFTMLEVEEEEECVARRKNSGLTMDCFRKTWLSNPPPSSSKSSSTKNASSSAAAVSGDNHLAPIPGFAAFGLATPGTAGNGNANANANANANAVTTMTKRWRRCARCAAVMEDVLSQRPTLQWLVMQQRRCFCSGYWDTLQQGEMAA
Length978
PositionTail
OrganismSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Sclerotiniaceae> Sclerotinia.
Aromaticity0.07
Grand average of hydropathy-0.254
Instability index41.23
Isoelectric point6.37
Molecular weight107300.55
Publications
PubMed=21876677

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription, DNA-templated	GO:0045893	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24701
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.42|      21|      78|      17|      38|       1
---------------------------------------------------------------------------
   17-   33 (27.61/13.19)	........DG..AGL......SLPSRPPPSKEL
   35-   67 (16.91/ 6.98)	QRIDelrgSGccQGIawskwgSIASIAPNGNGL
   91-  113 (30.90/12.64)	QLTN..nlDG..GPL......KHLSWSPTGSEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.59|      30|      78|     129|     165|       3
---------------------------------------------------------------------------
  130-  162 (45.79/28.45)	SGFRYDASQAPILgpSHPIPSKSAfLYVTSNGS
  851-  880 (53.80/22.17)	SGLTMDCFRKTWL..SNPPPSSSK.SSSTKNAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     353.01|     117|     281|     168|     309|       7
---------------------------------------------------------------------------
  168-  309 (180.89/161.47)	QQGNNKWFESHTELESIVSSDDLITHAAicaertpsLLIALATGSKQLRII...................RAGIDWgmpqtqekvnqmtlsLNASLRIKPLTVtSWMHDVPGDTL..NPS.....HLESSM...VQLSHLKF...LSPCIDSKNHMTPPIVMAVRSYLPGPTsH
  444-  592 (172.12/120.20)	NDGKVKWKQLDYHLGEIGSSMEDPRYAA........MITALSTSCSTSVMIfinyddiiatahsfaktkdNLAYDW...............LNELAKILKITV.DYSEEAHYDVLirNTTiqlclSIQNSLgfrGDFNPRKFagkFSWLVLQLRNIVVLVTMAANMKVPGPT.H
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24701 with Med16 domain of Kingdom Fungi
Unable to open file!