<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24695

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDLGDQLTNVLSCNNFASIAYEYFEAQSQTPSSTTTKKHLQDVETVWRRHGALVYYDTKREGIWVFQPSPNSPNKPLEGDELLSQANLPAVHGVELLKKDKGMYEPSNLAPNKSIMPTSLNTPTSTSSPSPLDNTIRNAQNVNARTMQANSAQNIYDPAASSPGVKSATGSADALPFLKEVQEHFISSVQGSIVHRLCSDHGFIPLNSRTLLFPSQSPSRSMAYYQSPKVSDNAVSLVNLDINLTSLGTLLIKACSYVTPGLQSISLSNPEKLQRILSQGTELWLAPGGNPAKFYSFYDDEQLPSIQPISDLQKYPEDQSWRFHGTTIKSWQSRCLDWLSTKGFDPTSIEEGGWMFVQVLNTNHVFSNPEYADMPFPDEGAIVPWPALLCFRAVKTSSTDLQPLNADSFGHVDPLTFAEEWSMNAEKQASIILNRQQERKILEAAKEQADREAQNIQANVNSAALMEKGNNAGAMYPTPPDAVHHPGGPTPSFDGAVTTPGNPAHLFSHDLEAANPSTSIMNTIDTEHWVTSEQKHRSNSNMNFSENDNDNDNLFGEMGGDLFGDTDITDADFNFFDQPDDMQMDPPPGSPVAACLPSAHQRNISEKSPISSKPSVPQAVSQDTIMEDAQPVENSLRQSVLKQSLAKPAKDMDVEMSNTNDSLVCPAPPRSPPRIMAPFDKETVFGQLVKRTSKLNSGSSVFDKVKFEYSLAEIDEKYGSHGRFRYTEDELKPQLIDPHDPTNPESLDRRKSENKRSGSEVLTQILNNESGQYEFELDNEVESDMANDFNSVSEASDSDETLPVGLSAMVRLGMKRKRYFDEGSISSYNAFTGEYEPSPATPQSIVEPQVPIFESDPADWSLTPYFTSPEPDIQPSGLSDQDLIETAQIIADQAASGNLRVNDQISQNADTHAQAIFATRRLMTAVLKATKTCLKDVKRCTLRSYLTIPGIPVVNPALRLPPRPMPNPRAAQNTEILRSSNLFPVQPPQLEVRRGDSKLAVLPPAIHFWDNLGLAPFTGNKDVNAICIYPDIVGITENADIFLDQMRGAYESFRFGGHDRIVFPDSPKGLIHYPNDECNQGIANTNAVACLSSLKDIMAQLSKNLSSMTAEEKNIVVYFVYPIDNSFLLVNICAAFKHLFKFYRKSLSEKKLKAVNELVLQLVPLDFMAAPNSLVVPSPAEYSRLAMEVYDRCVDFASSSTTAAILLEKPLPRNIDFKLHVNPSPALLQENSCLHIAYSQSIDERWITAAWSDNRGTKQMTASYCLGRKNEPFTLLFTDIANEIWETTLDLISSKKVHWRIIIAKTAVMEQPEIDFWTGLASTESNASISLTLVTVQTDPSLRILPPQTRIPPPSMTTTQSATTPVSTPQASQSSIFSPDNPSTPSRDSTTNAPTPSEAPAVPHEPDQNSRLLDITDQTWGAVLSHRLNNSNSLLEFNPALISGYLIKNSGTNTDDPPLVMEVNIIHAEVVGNPRTFHDTLLREILGYYRGLATLARVRGVVHPVRDGRPWHVAAAEKAVKALYMLV
Length1527
PositionKinase
OrganismSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Sclerotiniaceae> Sclerotinia.
Aromaticity0.07
Grand average of hydropathy-0.413
Instability index52.76
Isoelectric point5.06
Molecular weight168551.20
Publications
PubMed=21876677

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP24695
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     263.50|      86|     767|     569|     703|       1
---------------------------------------------------------------------------
   67-  163 (129.00/49.24)	QPSPNSPNKPlEGDELlsQANLPAVHgvellkkDKGMYEPSNLAPNKSImPTSLNTPTSTSSPSPLDNTIRNA...QNVN..ARTM...QANSAQNIYDPA.ASSP
  578-  672 (134.51/125.42)	QPDDMQMDPP.PGSPV..AACLPSAH.......QRNISEKSPISSKPSV.PQAVSQDTIMEDAQPVENSLRQSvlkQSLAkpAKDMdveMSNTNDSLVCPApPRSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.41|      24|      29|    1344|    1369|       2
---------------------------------------------------------------------------
  483-  500 (26.65/ 9.43)	VHHPGG..P.TPSFDGAVTTP......
 1344- 1369 (39.69/23.31)	ILPPQTriP.PPSMTTTQSATTPVSTP
 1376- 1400 (42.08/19.46)	IFSPDN..PsTPSRDSTTNAPTPSEAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     292.80|      95|     440|     245|     478|       3
---------------------------------------------------------------------------
  376-  478 (144.25/249.92)	FPDEGAIVPWPALLCFR..AVKTSSTDLQPlNADSFgHVDPltfaEEWSMN...AEKQASIILNRQQERKILEAAKEQADREAQ.NIQanVNSAALMEKGNNAGAMYPT
  819-  919 (148.55/47.48)	YFDEGSISSYNAFTGEYepSPATPQSIVEP.QVPIF.ESDP....ADWSLTpyfTSPEPDIQPSGLSDQDLIETAQIIADQAASgNLR..VNDQISQNADTHAQAIFAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     370.92|      95|     768|     206|     319|       4
---------------------------------------------------------------------------
  206-  305 (145.56/112.34)	LNSRTLLFPSQSPSRSMAYYQSP.KVSDNAVSLVNLDINLTSL.GTLLIKA.CSYvTPGLQSISlsNPEKLQRIlsQGTELWLAP.GG....NPAKF....YSFYDDEQLPS
  977- 1065 (115.36/72.19)	LRSSN.LFPVQPPQLEVRRGDSKlAVLPPAIHFWD.NLGLAPFtGNKDVNAiCIY..PDIVGIT............ENADIFLDQmRG....AYESF...rFGGHDRIVFPD
 1100- 1191 (110.00/80.48)	QLSKNLSSMTAEEKNIVVYFVYP...IDNSFLLVNICAAFKHL.FKFYRKS.LS..EKKLKAV...NELVLQLV...PLDFMAAP.NSlvvpSPAEYsrlaMEVYD......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.81|      34|      37|    1214|    1248|       5
---------------------------------------------------------------------------
 1214- 1248 (55.89/40.95)	NIDFKlHVNPSPALLQENSCLHIAYSQSIDERWIT
 1254- 1287 (59.92/39.46)	NRGTK.QMTASYCLGRKNEPFTLLFTDIANEIWET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.85|      34|     663|     738|     775|      12
---------------------------------------------------------------------------
  738-  775 (52.70/37.21)	PHDP.TNPESLDrrkSENKRSGSeVLTQILNNESGQYEF
 1403- 1437 (58.16/30.19)	PHEPdQNSRLLD...ITDQTWGA.VLSHRLNNSNSLLEF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24695 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GRFRYTEDELKPQLIDPHDPTNPESLDRRKSENKRSGSEVLTQI
2) LRILPPQTRIPPPSMTTTQSATTPVSTPQASQSSIFSPDNPSTPSRDSTTNAPTPSEAPAVPHEPDQNSRLLDIT
3) PSNLAPNKSIMPTSLNTPTSTSSPSPLDNTIRNAQNVNARTMQANSAQNIYDPAASSP
4) QQERKILEAAKEQADREAQNIQANVNSAALMEKGNNAGAMYPTPPDAVHHPGGPTPSFDGAVTTPGNPAHLFSHDLEAANPSTSIMNTIDTEHWVTSEQKHRSNSNMNFSENDNDNDNLFGEMGGDLF
5) TDITDADFNFFDQPDDMQMDPPPGSPVAACLPSAHQRNISEKSPISSKPSVPQAVSQDTIMEDAQPVENSLRQSVLKQSLAKPAKDMDVEMSNTNDSLVCPAPPRSPPRIMAPFDKET
722
1342
106
436
566
765
1416
163
563
683










Molecular Recognition Features






MoRF SequenceStartStop




NANANA