Description | Uncharacterized protein |
Sequence | MAAQPEVPLEEITWRSPQHVQMMGGYLHSNNILFYFAESPFFDKTSNNASLAVQASYNENFRHFLETREAFEGRLKGMQGLEFMVVHDPLQEAAAAGGIQQQRVQQEPSNVWVIRKQMRKKRAGLGSGPAGGDDEIQVLATYFVVGDSVYMAPSVLKIVGSRILSTVTSLTKALSAASPLPIFSPSYGHTYMPPVPKALESSRPGVQQSDQQSVTDTPMPDALLQSKDASALSSTAEQPSASTSVSPLTSSSTTMQDSRSLIEAFNLLSRYGDEYMDDAPLLGEPGSFIIGKTSTEPLVVGMRQPVNSKASKAPTPAPSTGVGGSMSKPGTPAATGTTTAISAIKTDPATIGVGKAGKGGEKSPTTPGGMKERTKRRKSKILSTAVVSSATGPGAGVS |
Length | 398 |
Position | Head |
Organism | Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.306 |
Instability index | 58.87 |
Isoelectric point | 8.86 |
Molecular weight | 41941.91 |
Publications | PubMed=19717792 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP24689 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 218.87| 60| 65| 175| 239| 1 --------------------------------------------------------------------------- 151- 201 (66.88/27.89) .................MAPSVLKivgSRILSTVTSLTKAL..........SAA...SPLPIFSPSY...GHTYMPPVPKALES 202- 264 (79.43/43.36) SRPGVQQSDqqsvtDTPMPDALLQ...SKDASALSSTAEQP..........SAStsvSPLT..SSS......TTMQDSRSLIEA 269- 334 (72.56/31.99) SRYGDEYMD.....DAP....LLG...EPGSFIIGKTSTEPlvvgmrqpvnSKA...SKAPTPAPSTgvgGSMSKPGTPAA... --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 70.84| 15| 42| 339| 353| 2 --------------------------------------------------------------------------- 339- 353 (23.88/ 9.99) TAISAIKTDPATIGV 355- 369 (24.85/10.65) KAGKGGEKSPTTPGG 384- 397 (22.12/ 8.77) TAVVSSATGPGA.GV --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AIKTDPATIGV 2) SPTTPGGMKERTKRRKSKILSTAVVSSAT | 343 363 | 353 391 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab