<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24688

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMEESFPLPLRPLIEKPATEPDSLPIRIAQINGQRGSFRNVTETSLQEEIHAERARNATGVEGEEEEEEEEEEEVESREAKSADRLEQLFKSRAEIIDFATQAHAEANYALDLVSLLVSRYTPRQAEMSMSPYLKQRAPLGSLGIDIIKTPEKTEAVQKEIADLSRGWKMENFDSAANKLLKSASRLEEEVTAETKYWAGVLNIKEKGWKVCRLPRERQTLGVQYGFLEATPTFRDRGLAALRRGNRGDLILDRGLQARKPRSLRVRVQHADRIVGTSKIVPLELAPGNDAIENHIRLTRDALYEEELFHELNREARTLLQHGIESKENLIQLPADSNQQILIDMVEPEECNIWDTDKQGHAEDALAETVAQSLRILLSHAHRQKYRRRTQIPPPVTSKRRANPEYSLLRPIVSYLRHKSALEWLKLFLSNITRTLQLAGLNCKYNISPLVSVKFPLVDTSNPSPWELDTPPFVERLVNSFLTPFESIVTGTLLSPTSIFKIRIVTNINPSAFGTEFEIGSNISSSPRTKSSSSRFGLRDDLQQLLLHLFTIDLVYLIPHLARDAGTEPSSLRPNTSLLKQEQGQEQEQPEQSGFNTPTPRHTSHLTSWIPTSPENGELTVFSPSQRRNKKLTIDLHPDKLTVRCQWLRSEIDVDGNMDWEMSTGEGDVIYWWGDGGGNEGKTLQSIVGLMSQEAIKAEFYILRRDLSKADRTQDRGAIDVELWRVSLLSQYPHLSFT
Length737
PositionHead
OrganismAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
Aromaticity0.07
Grand average of hydropathy-0.547
Instability index58.58
Isoelectric point5.70
Molecular weight83622.43
Publications
PubMed=19717792

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24688
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.19|      11|      15|      38|      48|       2
---------------------------------------------------------------------------
   38-   48 (18.34/12.58)	RNVTETSLQEE
   55-   65 (18.85/13.17)	RNATGVEGEEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.81|      18|      44|     446|     463|       3
---------------------------------------------------------------------------
  446-  463 (31.48/21.42)	ISPLVSVKFPLVDTSNPS
  493-  510 (31.34/21.29)	LSPTSIFKIRIVTNINPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.99|      12|     109|     261|     272|       4
---------------------------------------------------------------------------
  261-  272 (21.50/15.11)	RSLRVRVQHADR
  371-  382 (21.49/15.09)	QSLRILLSHAHR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.59|      12|      15|     560|     573|       6
---------------------------------------------------------------------------
  560-  573 (16.28/13.33)	LARDAGTEPSslRP
  578-  589 (21.31/10.89)	LKQEQGQEQE..QP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24688 with Med17 domain of Kingdom Fungi
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