<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24685

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPAGALTNFRVLNLLQGSTKVAEYAQLKSLTTYSAFYEGFISAISKTLTLHFTKQQKVIPLGTRTFYSSLEENGHQSGDDDLPFSRKSTSFLSILDINVTSKGRLAISLCTLPQPGLEQLLRDSESEIIGARLSDDVWIAPSGTLCRLISTDEYQSTQSNTVSPGHIATTPHEVELLASKMKADKREWKRCVTEWLRIFGLQLNDPEAELWVEVEVNALDRQLYILFSKSNWNHQKSSPFIRILWPLKLCFTRSRSKMTAPANPTEFFSGQAESPLQLAERWVKEPCPIRQPFDKHKTSDDPSELEKQQQKCSEPSPLKLDHPEMPESLARVINLPEAQLASAVYPTPPGGGLAQGMGAGIVSEGLGTSAIDTLHYTPTQSEQIYNETVGPAAYFRGTSELLPTGLDPTTSELGIGSGLYDTAADEDFFGDMDVANFDTKGITEADFNFFDEPEFTGLTGDLDMQTGEPEAVQQDTEANFTAPDSSDTAMSITEPSPSNNDQNHLTKSEHDTIKQPAFSSLITTADEDHICKETTELSQIISTDDSQKKRPISPPLSPVQIKKILSPDVLTNLRLTPFKSDISRLRIAPNQYSPVIFQPRLCSSDQKYKIDGKFWFTPGKRYITSNLGGSPSGIPTIGFPEKGRKVRPKPLPILTSLHPLISDNTLEIELQSPSTSSSGSSEGNSDTDHESNASSSHVMNFHPKRSRDYEVEGNSTPSPLDILTQTSDLDKGPLSEHQFALLGAFLSEGVDWPLTGYFSRKQNDIFPVFLRREDLLQTAQLVVDQITQSSFCHIRDDLHKPEWADWDDILSRSLFDNIDGMGHLSKLDLRTYVTLEDGSNPRKDGPSIRPNLTGSICKICPPHIKVHRGNSYLEILPSAIGFWETFGLEPLQGEKDIIPFCIYPPNVTEAAEAFIERLGLVYSSGNFGSHSRSNKANGLVPWSLNAASDQNYASLMHALNVSCENLATDKNVVIYIINPFIYDAAIVDICSAFLRLFHKYVGDIDRQHTRHLSELVLQIIPLEFIASADSLVVPTQTDYLRLALEVYSRCPPKDRSSDWLGCSPPLVLADPVPKVVPFRLAAESVAPLEEAKSLHVAYSHSVDQRWVTAAWTDNSGRHQSALSYCLRERDSPVSRPISEIRTQIWETSKDIMDMSLSHWRLIVVKDEPVDLEEVEMWTSLLDQYNRTKAIKVELGIISVNTKPGLSLKLPSSPLQPSALSQQAAQNGPSTTPGSTPRPVPSPDPSGPAATPPTANAPTCTDQHTPPQHAQQPSPDSDQDTILIDKSDETWGVTLSHRLNNSYYLTKHQPALASGYLFRRSGVSDTDGQAVMAVNIIYTNSRRPIDHLLKDILRMYRELITLARVRGIVHAQGNSPLPWHIMTAVKGQEMLCYTL
Length1396
PositionKinase
OrganismAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
Aromaticity0.08
Grand average of hydropathy-0.389
Instability index52.06
Isoelectric point5.26
Molecular weight154729.32
Publications
PubMed=19717792

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP24685
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     204.48|      61|     188|    1053|    1136|       1
---------------------------------------------------------------------------
  620-  681 (100.06/49.90)	PGKRYITSNLGGSP.....SGIPTIgFPEKGRKVRPKPLPILTSLHPLISDNTLEIELQSPSTSSSG
 1053- 1118 (104.42/91.44)	PPKDRSSDWLGCSPplvlaDPVPKV.VPFRLAAESVAPLEEAKSLHVAYSHSVDQRWVTAAWTDNSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.39|      25|      29|    1218|    1245|       2
---------------------------------------------------------------------------
 1218- 1245 (40.92/31.98)	PSALSQQAaqNGPSTTPGSTPrP....VPSPD
 1249- 1277 (47.47/26.24)	PAATPPTA..NAPTCTDQHTP.PqhaqQPSPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.62|      18|      31|     432|     449|       3
---------------------------------------------------------------------------
  432-  449 (33.78/24.74)	GDMDVANFDTKGI...TEADF
  462-  482 (26.84/17.93)	GDLDMQTGEPEAVqqdTEANF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.14|      16|      33|     369|     384|       4
---------------------------------------------------------------------------
  369-  384 (29.42/17.94)	GTSAIDTLHYTPTQSE
  399-  414 (28.73/17.32)	GTSELLPTGLDPTTSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.27|      13|      33|    1131|    1147|       5
---------------------------------------------------------------------------
 1131- 1147 (14.62/19.75)	RDSPVSrpISEIrtQIW
 1167- 1179 (24.65/13.32)	KDEPVD..LEEV..EMW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.24|      18|      69|     195|     215|       6
---------------------------------------------------------------------------
  195-  215 (30.76/24.72)	TEWlriFGLQLNDP..EAELWVE
  267-  286 (29.48/15.75)	TEF...FSGQAESPlqLAERWVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.42|      36|     187|     300|     338|       7
---------------------------------------------------------------------------
  300-  338 (59.74/38.68)	TSDDPSElekQQQKCSEPSPLKLDHPEMPESLARVINLP
  483-  518 (63.68/34.70)	TAPDSSD...TAMSITEPSPSNNDQNHLTKSEHDTIKQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.85|      16|      17|     848|     863|      11
---------------------------------------------------------------------------
  840-  855 (27.50/13.67)	GSNPRKDGPSIRPNLT
  856-  871 (31.36/16.65)	GSICKICPPHIKVHRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.62|      11|      17|     921|     931|      12
---------------------------------------------------------------------------
  921-  931 (21.19/12.71)	GLVYSSGNFGS
  940-  950 (21.44/12.95)	GLVPWSLNAAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.46|      28|      77|     891|     920|      13
---------------------------------------------------------------------------
  891-  920 (41.90/32.98)	EPLQGEKDII.....PFcIYPPNVTEAAEAFIeRL
  966-  998 (41.56/22.79)	ENLATDKNVViyiinPF.IYDAAIVDICSAFL.RL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.92|      47|     544|     754|     802|      15
---------------------------------------------------------------------------
  754-  801 (81.99/60.85)	WPLT........GYFSRKQNDIFPVFL.RREDLLQT...AQLVVDQITQSSFCHIrDDLH
 1292- 1350 (65.93/42.37)	WGVTlshrlnnsYYLTKHQPALASGYLfRRSGVSDTdgqAVMAVNIIYTNSRRPI.DHLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.98|      12|      20|     520|     531|      16
---------------------------------------------------------------------------
  520-  531 (20.40/12.04)	FSSLITTADEDH
  539-  550 (19.58/11.25)	LSQIISTDDSQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.04|      11|      20|     688|     698|      17
---------------------------------------------------------------------------
  688-  698 (19.01/12.00)	DTDHESNASSS
  710-  720 (20.03/13.11)	DYEVEGNSTPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24685 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IELQSPSTSSSGSSEGNSDTDHESNASSSHVMNFHPKRSRDYEVEGNSTPSPLDILTQTS
2) IRQPFDKHKTSDDPSELEKQQQKCSEPSPLKLDHPEMPESLARV
3) LSLKLPSSPLQPSALSQQAAQNGPSTTPGSTPRPVPSPDPSGPAATPPTANAPTCTDQHTPPQHAQQPSPDSDQDTILIDKS
4) PEFTGLTGDLDMQTGEPEAVQQDTEANFTAPDSSDTAMSITEPSPSNNDQNHLTKSEHDT
670
291
1207
455
729
334
1288
514










Molecular Recognition Features






MoRF SequenceStartStop




NANANA