<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24684
Description |
Mediator of RNA polymerase II transcription subunit 7 |
Sequence | MAEAGQQKVTAAFPPPPPFWKHFTSQNLKKLDECKKEHEEKSGSKQIWTPEALRMLELPPELRFLVPPQAPTSSSYSLFGESQSVSINLPSLQEQGIEQLYPSPPSGNALPANHRFYLLKISKSLLLNFLEFIGILALCPERFESKVQDIRNLFINAHHLLNLYRPHQARESLIMLMEEQLDRTKEEIKEMDRIKVNVEGFLKQLEAEGSNIANASSAKSGSSLKQPDSTAQEEDAIEEARSIWNLLDHIDED |
Length | 253 |
Position | Middle |
Organism | Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.521 |
Instability index | 64.82 |
Isoelectric point | 5.29 |
Molecular weight | 28688.23 |
Publications | PubMed=19717792
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery.
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364060
ECO:0000256 ARBA:ARBA00003669
|
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi
|
Interaction
Repeat regions
Repeats |
>MDP24684
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 83.53| 24| 50| 40| 64| 1
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40- 64 (38.88/24.90) EKSGSKQIWtPEALRMLELPPELRF
93- 116 (44.65/24.68) QEQGIEQLY.PSPPSGNALPANHRF
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