<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24680

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDGTSANGPGRGIERQHVDDTLSTTASLAPYNNGNHSNGPSHAKDAACPSNPKFDDFLPPELVHITQGFFPLGHLINRATQQCWNDLTDLITELANPQSTATHATAGPVTTTNGKYTLSPSSAENAQKKLRILEFAQAKRADFIKILVLSQWSRRAADVSRLIDIQAFIRMRYDFYNGAILSIGEMKRDLIRAQTANPDLAMALEVLATGRVAAIQERSFVPPKPLTPKKMLKTLKKINKTIRTRLVLHDQIPRAFTNYVVHDGRVTFKVPTEFEVDLSIAQESHSSQFFFVDIRFLFSPSPPKPAGRLLDELDNRVNAILMHSGLTGCYNLLHNLILSNKITILFHQAVELAREHWLDTLRVEVLHRTLVVQYWINRPGPKSWIEIGVKGGRRKEQTHDGSITESPFLGLRWMRDNKEVESKDIKLDPELLSMETILCSVTALHISFLLQSTYTKLSQERLYASGALSVGLQTSINEPGNCFLNVQLTKGRSLRVMIEPVSGAIIFRPTPLLLNRYDIDRSFERPIIDDILFRISRIRSTAVIEEVESLATALGWETVNSRDIKNEDLRRIFPSNILRSVLFFRKSWECNYGIAYTCSMDGDNWWVVELRAPSRDKGPFSPQSARMVTGRFGGLPERLNYASFSQLDYALSGMLAIHVNACYLSEVHGIHYFPPVRNLSLGPHLQVPSIFIRFRSGSLPSALRISPSITADKNPTVRDTVRLSFRGIHPSSQCAILLAHGNLSREIKDLALLAVHLDPTITFQPNGRGFAMRFLTPVGKPMIIQLLARLQQLEHVISTLDTLKQKSLKLLSVSLSKIKFSYAADEGARAIINFNYHEQSIESDIDSVTLLSRQAPLMLLRMSIDFHPQNPHRRIKESLTSTLNGLRPGARAGAGLEAVLKLLVITRPILQALERISTGSRSNLPGNSGVQITTRSSKIFHLRYPSLRYRFCIHAGLRRDRVVWVLRDMTTMSDKTGREAVELKLKEQIFGASGDGWQGLGNGAIADCEKIGNLVSTLHGVLTDYISSETGGRLGMNPLGKRNGGTGTDLDPGPGGSSGGSDDVGL
Length1066
PositionTail
OrganismAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
Aromaticity0.07
Grand average of hydropathy-0.189
Instability index44.47
Isoelectric point9.45
Molecular weight118562.73
Publications
PubMed=19717792

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP24680
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.09|      20|      99|     373|     393|       1
---------------------------------------------------------------------------
  373-  393 (35.30/31.07)	QYWINRPGpKSWIEIGVKGGR
  473-  492 (36.79/25.91)	QTSINEPG.NCFLNVQLTKGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.17|      37|      47|     779|     815|       2
---------------------------------------------------------------------------
  779-  815 (59.49/40.22)	GKPMIIQLLARLQQLEHVISTLDTL.KQKSLKLLSVSL
  827-  864 (56.68/37.98)	GARAIINFNYHEQSIESDIDSVTLLsRQAPLMLLRMSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.78|      16|      47|     518|     533|       3
---------------------------------------------------------------------------
  518-  533 (28.82/17.33)	DIDRSFERPIIDDILF
  568-  583 (27.96/16.59)	DLRRIFPSNILRSVLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     278.69|      68|      99|      89|     156|       4
---------------------------------------------------------------------------
   24-   91 (65.23/39.11)	...........TTASL.APY..NNGNHSNGPSHAKDAacPSNPKFDDFLPPELVHITQgF.FPLGHLINRAtqqcwndltDLI
   92-  163 (100.72/64.78)	TELANPQ.STATHATA.GPVTTTNGKYTLSPSSAENA..QKKLRILEFAQAKRADFIK.I.LVLSQWSRRA.....advsRLI
  193-  255 (70.24/42.74)	AQTANPDlAMALEVLAtGRVAAIQ.ERSFVPPKPLTP..KKMLKTLK....KINKTIR.TrLVLHDQIPRA............
  272-  310 (42.51/22.69)	TEFEVDL.SIAQESHS.SQFFFVDIRFLFSPSPPKPA..GRLL........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.69|      47|      95|     610|     660|       6
---------------------------------------------------------------------------
  610-  660 (75.63/61.84)	LR.APS..RDKGPFSPQSARMvtgRFGGL.PER.....LNYASFSQLDYALSgMLAIHVN
  703-  758 (61.06/37.92)	LRiSPSitADKNPTVRDTVRL...SFRGIhPSSqcailLAHGNLSREIKDLA.LLAVHLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.52|      11|     255|     684|     694|       7
---------------------------------------------------------------------------
  684-  694 (21.71/13.67)	HLQVPSIFIRF
  941-  951 (22.81/14.74)	HLRYPSLRYRF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24680 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MDGTSANGPGRGIERQHVDDTLSTTASLAPYNNGNHSNGPSHAKDAACPSN
2) RLGMNPLGKRNGGTGTDLDPGPGGSSGGSDDVGL
1
1033
51
1066










Molecular Recognition Features






MoRF SequenceStartStop




NANANA