<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24677

Description Uncharacterized protein
SequenceMAGKHQADVDLISQIAAASAVKSSPHRNQLTLDNENGLIVPMSTIGTSAMFGNDPPSFFPPTAFTSLRSQSTLQNTVIDLTESDHSGAADGERPAKRPRLDAGNGPSQSSEDPLQNQHQQHHQSQNQSSSQHHGSSTASEAPESSMNPLDLMNASSTEQTARPPWSFPSDIRRTGPGAQTELAQWSQSASLPPLPIRPWKYGIQERYVAGATNQKKNEECGEVTTTPYRIDVPSIAPRFADNKPADFAPWRGSHPEDVLSEQTIKQGFHDRSPVPPTESTSARTSVYPHFKRRSGLKLLSSVFAAALEKRQALCTITAASTFRPPPRVTLTDIKREAWLRDLANPSIPLRRLSRTIPHGIRGKLLLDQCLGKSIPICRAIWLAKCVGANELRAFKRKGTSAGVASGLETKWVRDWTVSVQQFIEGVIASFGDASWKLRISYSIRLSARIFLEHLIEQDHFLDWFLTSLDNSSFESLPVWLLMVGVYWQNIVRYRKRAKRLAECLLEKLRLVSDAGQNAHLNPVAQRLSRLTKTLTLYHPSSFILPRTWAKYESVLSSCLDMNLPEDKAAFQNLKARNTRHVSADIGLLGHLPPHRLPSHIWNLRNTLLSRTGFSVALENDTIQLIKASVRRRLPHMFPMLSIDGDAEMTDDVDLTSLSWTVRSEIGNWIRNQVASHVKNSLKSAIDRDFASEAKTSALTPQEFFEVRYILECLCDFSMLADVLKYASGSNNVTVVASAVDTLNYHLDSFNAIGATGDLFKSFTGAYARISKTELSVQDLIASLLDVAIKLPAELSTLSMLRRDQLQRDRKLAMAACSPVSDHIVDTLNTANPTFTEELDQLLTSGNSMDESTMARIFDTLRKKLEAGSINGEQSAHETARYFANLRPFNTKLFDNLMIKWVISVLRTSPRPKLSSILPPLIGVGCVTLHSFYVLARAFLHSDAHKNAIPDLAELRIDMIQLLDDKLSNGNGSQGLVAYRFKIARQGYMRQYSGEALGLIQDLLANLSENGVDTPPKQFNNDMLSTIVTPLLCEIIVRHPSIVGIGLAAAERTIESINDFSLPLCLINLRLLFNFECDNDVKKRIYDVVFEAAKSNMHKGQSHWIDVVGTLHADAATEIRQRAEEQLLSLVLSSDSLPASPVSKSGAPTSITASALVCLRIVENLSFSVPENGSPSLGPMLIEKMNMILHRITILESHIMNINITQYNDQAAAIRQAHATQESAITFWFYILLRLVSIHRSTFTPGTLSKSDLADQSRLLISITCIALSKTLSPKVPSAQPYYIPPTTPLTFAVPLQGSQPQPLFYSTDAGISTNLRTQALDVAATLLDSIPDDSRHQCSRFFRDRCPPFLHPQNNPRLFFLLGPLAADTQPSSSTMQSSQQQPVVPNLSQTTLGPPASTATPAAGAPPGAKSNSSSSQQFQSGNIYNTTNFLPFDDQNSLVGKLRVQHPGGIVGRFPLRPWEMLEESAPVIGVNDTAVDLGWFAARKVRGDVT
Length1493
PositionKinase
OrganismAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
Aromaticity0.07
Grand average of hydropathy-0.225
Instability index47.35
Isoelectric point8.36
Molecular weight164725.45
Publications
PubMed=19717792

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24677
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     402.84|     136|     537|     735|     893|       1
---------------------------------------------------------------------------
  391-  519 (162.75/98.81)	LRAFKRKGTSAGVASGLETKWVRdwtVSVQQF.IEGVIASFGDASWKLRISYSiRLSarIFLEHLIEQDHFL.........DWFLTSLD..NSSFESLPVWLLMVGvywqNIVRYRKRAkRLAECLLEKLRLVSDAG.QNAH.......................
  746-  893 (210.08/178.38)	LDSFNAIGATGDLFKSFTGAYAR...ISKTELsVQDLIASLLDVAIKLPAELS.TLS..MLRRDQLQRDRKLamaacspvsDHIVDTLNtaNPTFTEELDQLLTSG....NSMDESTMA.RIFDTLRKKLEAGSINGEQSAHETARYFAN.LRPF.....NTKLF
 1310- 1359 (30.02/ 6.11)	.........................................................................................................G....ISTNLRTQA...LDVAATLLD..SI.PDDSRHQCSRFFRDrCPPFlhpqnNPRLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.24|      54|     105|    1126|    1179|       2
---------------------------------------------------------------------------
 1126- 1179 (90.09/50.51)	LLSLV.LSSDSLPASPVSKSG.APTSITASALVCLRIVENLSFSVPENGS...PSLGPM
 1231- 1289 (78.14/42.78)	LLRLVsIHRSTFTPGTLSKSDlADQSRLLISITCIALSKTLSPKVPSAQPyyiPPTTPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     145.70|      37|      39|      39|      75|       3
---------------------------------------------------------------------------
   28-   68 (57.83/29.45)	NQLT...LDN.........................englIVPMSTIGTSAMFGN.DPPSFFP.......PTAFTSLR
   69-  106 (54.25/27.18)	SQST...LQN............................tVIDLTESDHSGAADG.ERPAKRP.......RLDAGNGP
  107-  183 (33.61/14.06)	SQSSedpLQNqhqqhhqsqnqsssqhhgsstaseapessMNPLDLMNASSTEQTaRPPWSFPsdirrtgPGAQTELA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24677 with Med12 domain of Kingdom Fungi
Unable to open file!