<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24674

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLAEALLEQAMIGPSPNPLILSYLKYAISSQMVSCSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLQEGLEAGTPAPGEKQLALCLQCLEKTLSSTKNRALLHIAKLEEASLHTSQGLGQGGTRANQPTASWTAIEHSLLKLGEILANLSNPQLRSQAERCGTLIRSIPSMLSVHSEQLHKTGFPTIHALILLEGTMNLTGEMQPLVEQLMMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTQELKWTAFTYLKIPQVLVKLKKYFHGEKDFTEDVNCAFEFLLKLTPLLDKADQRCNCDCTNFLLQECNKQGLLSEVNFASLVGKRTADRDPQLKSSENANIQPNPGLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTHGSGESTKTASVRALLFDISFLMLCHVAQTYGSEVILSESSSGEEVPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLYSENTLQFYNERVVIMNSILEHMCADVLQQTATQIKFPSTGVDTMPYWNLLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHILDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVQLLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASSRQKKRHREDIEDYVSLFPVEDMQPSKLMRLLSSSDDDANILSSPTDRSMNSSLSASQLHTVNMRDPLNRVLANLFLLISSILGSRTAGPHTQFVQWFMEECVGCLEQDSRGSILQFMPFTTVSELVKVSAMSSPKVVLAITDLSLPLGRQVAAKAIAAL
Length1006
PositionTail
OrganismMus musculus (Mouse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Mus> Mus.
Aromaticity0.07
Grand average of hydropathy0.009
Instability index46.86
Isoelectric point6.47
Molecular weight111859.81
Publications
PubMed=17242355
PubMed=19468303
PubMed=21183079

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
ubiquitin ligase complex	GO:0000151	IEA:Ensembl

GO - Biological Function
histone acetyltransferase activity	GO:0004402	IEA:Ensembl
protein-containing complex binding	GO:0044877	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl
ubiquitin protein ligase activity	GO:0061630	IEA:Ensembl

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24674
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.71|      50|     193|     584|     644|       1
---------------------------------------------------------------------------
  595-  644 (84.74/58.24)	CLSISAAILEILNAWENGVLAFES.IQKITDNIKGKVCSLAV.CAVAWLVAH
  790-  841 (78.98/37.32)	CLDMQQVTLVLLGHILPGLLTDSSkWHSLMDPPGTALAKLAVwCALSSYSSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     171.06|      58|     193|     209|     278|       3
---------------------------------------------------------------------------
  209-  278 (74.15/96.97)	TAIEHSLLKLGEIlANLS.NPQLRSQAErcGTLIRSIPSMLSVHSEQlhktgfPtiHALILLEGTMnLTGE
  405-  463 (96.92/74.75)	TADRDPQLKSSEN.ANIQpNPGLILRAE..PTVTNILKTMDADHSKS......P..EGLLGVLGHM.LSGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.08|      47|     192|     721|     774|       4
---------------------------------------------------------------------------
  721-  774 (73.27/59.78)	KRPIKEVLTDIFakVLEKGWVDSRSIHIldtllHMGGVYWFCNNLIKELLKETR
  911-  957 (83.81/51.60)	RDPLNRVLANLF..LLISSILGSRTAGP.....HTQFVQWFMEECVGCLEQDSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.90|      40|     191|     326|     379|       5
---------------------------------------------------------------------------
   61-  117 (57.44/31.49)	LSYLKyaissqmvsCSSVLTAISKF....DDFSRDL.C.......VQALLDIMDMFCDrlsChgkaeEC
  327-  378 (59.46/63.93)	FTYLK.........IPQVLVKLKKYfhgeKDFTEDVnCafefllkLTPLLDKADQRCN...C.....DC
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24674 with Med24 domain of Kingdom Metazoa
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