<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24674

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLAEALLEQAMIGPSPNPLILSYLKYAISSQMVSCSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLQEGLEAGTPAPGEKQLALCLQCLEKTLSSTKNRALLHIAKLEEASLHTSQGLGQGGTRANQPTASWTAIEHSLLKLGEILANLSNPQLRSQAERCGTLIRSIPSMLSVHSEQLHKTGFPTIHALILLEGTMNLTGEMQPLVEQLMMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTQELKWTAFTYLKIPQVLVKLKKYFHGEKDFTEDVNCAFEFLLKLTPLLDKADQRCNCDCTNFLLQECNKQGLLSEVNFASLVGKRTADRDPQLKSSENANIQPNPGLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTHGSGESTKTASVRALLFDISFLMLCHVAQTYGSEVILSESSSGEEVPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLYSENTLQFYNERVVIMNSILEHMCADVLQQTATQIKFPSTGVDTMPYWNLLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHILDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVQLLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASSRQKKRHREDIEDYVSLFPVEDMQPSKLMRLLSSSDDDANILSSPTDRSMNSSLSASQLHTVNMRDPLNRVLANLFLLISSILGSRTAGPHTQFVQWFMEECVGCLEQDSRGSILQFMPFTTVSELVKVSAMSSPKVVLAITDLSLPLGRQVAAKAIAAL
Length1006
PositionTail
OrganismMus musculus (Mouse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Mus> Mus.
Aromaticity0.07
Grand average of hydropathy0.009
Instability index46.86
Isoelectric point6.47
Molecular weight111859.81
Publications
PubMed=17242355
PubMed=19468303
PubMed=21183079

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
ubiquitin ligase complex	GO:0000151	IEA:Ensembl

GO - Biological Function
histone acetyltransferase activity	GO:0004402	IEA:Ensembl
protein-containing complex binding	GO:0044877	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl
ubiquitin protein ligase activity	GO:0061630	IEA:Ensembl

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24674
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.71|      50|     193|     584|     644|       1
---------------------------------------------------------------------------
  595-  644 (84.74/58.24)	CLSISAAILEILNAWENGVLAFES.IQKITDNIKGKVCSLAV.CAVAWLVAH
  790-  841 (78.98/37.32)	CLDMQQVTLVLLGHILPGLLTDSSkWHSLMDPPGTALAKLAVwCALSSYSSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     171.06|      58|     193|     209|     278|       3
---------------------------------------------------------------------------
  209-  278 (74.15/96.97)	TAIEHSLLKLGEIlANLS.NPQLRSQAErcGTLIRSIPSMLSVHSEQlhktgfPtiHALILLEGTMnLTGE
  405-  463 (96.92/74.75)	TADRDPQLKSSEN.ANIQpNPGLILRAE..PTVTNILKTMDADHSKS......P..EGLLGVLGHM.LSGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.08|      47|     192|     721|     774|       4
---------------------------------------------------------------------------
  721-  774 (73.27/59.78)	KRPIKEVLTDIFakVLEKGWVDSRSIHIldtllHMGGVYWFCNNLIKELLKETR
  911-  957 (83.81/51.60)	RDPLNRVLANLF..LLISSILGSRTAGP.....HTQFVQWFMEECVGCLEQDSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.90|      40|     191|     326|     379|       5
---------------------------------------------------------------------------
   61-  117 (57.44/31.49)	LSYLKyaissqmvsCSSVLTAISKF....DDFSRDL.C.......VQALLDIMDMFCDrlsChgkaeEC
  327-  378 (59.46/63.93)	FTYLK.........IPQVLVKLKKYfhgeKDFTEDVnCafefllkLTPLLDKADQRCN...C.....DC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24674 with Med24 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA