<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24661

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDADHNGTINRSPAPPPPPAATPPAATQPQLPVSTTSTTTHTNGNLISHNDNHQSTHPEPEIPHITENLLPLANVLKYYSQQSFKQLATAVENLSKTAEEESDVKRKKYLLEVLVLLRRDFVKLYTLVKWSSVSQDVSKFIDLLNWFRLQDFNFDLLMYSLQGLLGFGAAKLPNFDLETALEVFYKKRPQLPSHNYLEKKEISPEKILEVMRDLNLAILTRFALMDLPSRFEYEVRDGRAYVQVKDEFEVSITMADDSIVDVDNGDKNEVENGSEDADYGRERNFNNPLYMIDFKFLFGINPNTGFIAYDNGYNYTTRLPPKSFVRLERVANQTLAKNGLHGLYELLHKYTISFKMYLISKQLRELMSSTKWKGNLQINYRAGSSVIVINYWTTLYLSLNWKSFIEIGVDEESKLHYRWFKNGRYEQQSIVNEIVGSNRLEGRIEDEDGDDDLFEVDSPREINIEETITAFILEHSKTIMQKICKTLELSCPHEITEMTPQQLSFSISPKKSTIFAINPLTGLFYFLDPSPVQLRLLKRINSAPPPASLLMNKQFISEYDITEWVASNILQLKLETFSKEVNYYLTATEWISNSIIRFNEPEVRKLLESILIGHGGRANPSNKSINGDGNNNVNGNSDDTDASAKTANINATVSSYANFKIQFYRKKHWPSTWFLIVMISGTTSRTNWWVARIKSVGANWIVNHFQLLSHNPELSYDFFKQLGKSSFQMIINHVVLEEMRERNVRVGVVNDDGGDDNGDSDNAKLFNISNDSYKEPTSVSSENGSAGIGIPEITDKASLVDGDLMHRSLISVINEGLLPIENSSPRLYLEIQLINQIQNHDNHAFNHLNKKMHLRLFGKLKNLDIKSSPELEKLNLIIDEKNQSFEILTSRDLEEIIGDSGKTHFLDTIFNSLSKLNNLLKILDQLKSNDIKVLDNSTDEITIKANDSLDKLVIKIPNEAAESISIGTIARKTWETELIIHFLNQYLSQNHSDNIVGIIKYLSDINPIFQTIKQVQSMLHEQQDSLKLNNGLHKIHFDCVFNNLNHIQFMFNLSSTINNSKKIQKDKILISLQFKRNKFDKLGKKQERLVKISFQNNPHVKQTKFKKLFDMMYKSILEMERDKNDELINFDESQVLVKLNQDILASTNLVEQMMQRITKCFIQYVSE
Length1167
PositionTail
OrganismLodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Lodderomyces.
Aromaticity0.09
Grand average of hydropathy-0.415
Instability index39.45
Isoelectric point5.98
Molecular weight133838.47
Publications
PubMed=19465905

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP24661
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.30|      16|      17|    1062|    1077|       1
---------------------------------------------------------------------------
 1062- 1077 (25.87/17.43)	KI.QKDKILISLQFKRN
 1081- 1097 (21.43/13.10)	KLgKKQERLVKISFQNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.70|      12|      17|     119|     130|       2
---------------------------------------------------------------------------
  119-  130 (21.86/13.64)	RDFVKLYTLVKW
  135-  146 (21.84/13.62)	QDVSKFIDLLNW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.92|      25|     526|     190|     218|       4
---------------------------------------------------------------------------
  190-  218 (38.71/29.93)	QLPSHNylekKEIS................PEKILEVMRDLNLAI
  706-  746 (34.21/17.66)	QLLSHN....PELSydffkqlgkssfqmiiNHVVLEEMRERNVRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.65|      55|     526|     309|     367|       5
---------------------------------------------------------------------------
  309-  367 (85.47/77.35)	YDN.GYNYttrLPPKSFVRL.ERVANQTL.AKNGLHGLYELLHKYTISFKMyLISKQLRELM
  840-  897 (78.18/56.61)	HDNhAFNH...LNKKMHLRLfGKLKNLDIkSSPELEKLNLIIDEKNQSFEI.LTSRDLEEII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.03|      19|      24|     562|     585|       9
---------------------------------------------------------------------------
  562-  585 (28.68/29.30)	TEWVASNILQlkletFSK.EVNYYL
  588-  607 (29.34/17.75)	TEWISNSIIR.....FNEpEVRKLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24661 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MDADHNGTINRSPAPPPPPAATPPAATQPQLPVSTTSTTTHTNGNLISHNDNHQSTHPEPEIPH
1
64










Molecular Recognition Features






MoRF SequenceStartStop




NANANA