<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24657
Description |
Mediator of RNA polymerase II transcription subunit 18 |
Sequence | MVHQLFLVSSIPHANYLQAVATLQAITGQLEPQEISTYTLITKPNHVFKPQVKAGKINQIEQHYMKCITTWQDYPFDISLPVIESKLDGKSEITAKKLFVEEEVVEEEEDDDAEKKRQRERGEFFTALGYKNGEQSQFGREKVWTLQIGDIPIAGKNQVCLQQTIYSSTLVHTHVAVPPKTASTDGAEAIQQAGQELGIEIKQELKPILGLNESTIKEEKMAESNKDLNTDGSDSMDIDIVEQKIKAESVPPKPRRRNDSFLVFLNDLGYSVINQYWVKGVRFFYGDIVIELFKLFIRDDHAPKDNLDGIKLKLLDESNTFQIKCYINVSKSTDIDQINQGVKDLAHLKDFLKGLFVLEIPDRMYLDSRVSNPIK |
Length | 375 |
Position | Head |
Organism | Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade>
Lodderomyces.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.424 |
Instability index | 41.89 |
Isoelectric point | 5.28 |
Molecular weight | 42632.03 |
Publications | PubMed=19465905
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364150
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP24657
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 139.88| 44| 44| 147| 190| 1
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147- 190 (73.88/44.60) QIG.DIPIAGKNQVCLQQTIYSSTLVHTHVAVPPKTASTDGAEAI
192- 236 (65.99/39.19) QAGqELGIEIKQELKPILGLNESTIKEEKMAESNKDLNTDGSDSM
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