Description | Mediator of RNA polymerase II transcription subunit 10 |
Sequence | MTTTQLVPNDNSSKELIEIADQISNIIESFIEVGILVHDNQGTPQSNAALSSKMQQLTRQLKHLSNVDPKLIEDYKIPIDVISYVEDGRNPDIYTREFVEVSAKLNARLKGKMQGFAKLQEVLGDKLQTEFPRLEKGVENVKTRTSG |
Length | 147 |
Position | Middle |
Organism | Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Lodderomyces. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.482 |
Instability index | 41.80 |
Isoelectric point | 5.44 |
Molecular weight | 16498.54 |
Publications | PubMed=19465905 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364146 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP24647 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 93.69| 30| 53| 3| 34| 1 --------------------------------------------------------------------------- 3- 34 (45.93/33.71) TTQLVPNDNSSKELIEiaD.QISNIIESFIEVG 58- 88 (47.76/29.27) TRQLKHLSNVDPKLIE..DyKIPIDVISYVEDG --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) LIEDYKIPIDVISYV 2) PDIYTREFVE | 71 91 | 85 100 |
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